Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387517267> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4387517267 abstract "Posaconazole is a potent, extended-spectrum triazole antifungal used for the treatment and prophylaxis of serious fungal infections. Previous reports have demonstrated hyperlipidemia resulted in significant changes in posaconazole pharmacokinetics and tissue distribution in rats. However, the effect of hyperlipidemia on the pharmacokinetics of posaconazole in patients has not yet been reported. We report a case of a 34-year-old woman who experienced a supratherapeutic posaconazole trough concentration (PTC) associated with hyperlipidemia after haploidentical hematopoietic stem cell transplantation (HSCT). The patient was admitted 13 months after HSCT for recurrent cough and sputum. She was treated with caspofungin due to developing invasive fungal infection of Candida tropicalis. After 10 days, caspofungin was discontinued due to the poor therapeutic efficacy and replaced with amphotericin B. Afterwards, the condition of the patient improved significantly and she was switched to daily oral posaconazole tablet. Therapeutic drug monitoring (TDM) of posaconazole showed a PTC was 3.2 mg/L. After discharge, she continued to receive posaconazole tablet as antifungal treatment. Two months later, laboratory tests at outpatient showed her blood lipid levels were significantly elevated and PTC was increased to 9.38 mg/L. Therefore, the posaconazole tablet was discontinued and she received lipid-lowering therapy. A few days later, the PTC was down to 5.22 mg/L. No medication errors and significant drug interactions were found. Hence, supratherapeutic PTC for this patient may be caused by hyperlipidemia which altered pharmacokinetics of posaconazole. Our findings highlight the need for close TDM in order to avoid supratherapeutic PTC if hyperlipidimia occurs during posaconazole use." @default.
- W4387517267 created "2023-10-12" @default.
- W4387517267 creator A5025486223 @default.
- W4387517267 creator A5034649465 @default.
- W4387517267 creator A5077931358 @default.
- W4387517267 date "2023-10-01" @default.
- W4387517267 modified "2023-10-15" @default.
- W4387517267 title "Supratherapeutic posaconazole concentrations associated with hyperlipidemia in a patient with HSCT" @default.
- W4387517267 cites W1887206955 @default.
- W4387517267 cites W2079899732 @default.
- W4387517267 cites W2101785863 @default.
- W4387517267 cites W2158597663 @default.
- W4387517267 cites W2166069286 @default.
- W4387517267 cites W2331415774 @default.
- W4387517267 cites W2375471655 @default.
- W4387517267 cites W2407108277 @default.
- W4387517267 cites W2586567370 @default.
- W4387517267 cites W2606856573 @default.
- W4387517267 cites W2763681245 @default.
- W4387517267 cites W2982356680 @default.
- W4387517267 cites W3019529976 @default.
- W4387517267 cites W3202436781 @default.
- W4387517267 cites W4297988839 @default.
- W4387517267 cites W4303438206 @default.
- W4387517267 doi "https://doi.org/10.1016/j.jiac.2023.10.008" @default.
- W4387517267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37832823" @default.
- W4387517267 hasPublicationYear "2023" @default.
- W4387517267 type Work @default.
- W4387517267 citedByCount "0" @default.
- W4387517267 crossrefType "journal-article" @default.
- W4387517267 hasAuthorship W4387517267A5025486223 @default.
- W4387517267 hasAuthorship W4387517267A5034649465 @default.
- W4387517267 hasAuthorship W4387517267A5077931358 @default.
- W4387517267 hasConcept C112705442 @default.
- W4387517267 hasConcept C126322002 @default.
- W4387517267 hasConcept C134018914 @default.
- W4387517267 hasConcept C16005928 @default.
- W4387517267 hasConcept C2778566413 @default.
- W4387517267 hasConcept C2779091943 @default.
- W4387517267 hasConcept C2779548794 @default.
- W4387517267 hasConcept C2780272996 @default.
- W4387517267 hasConcept C2780402444 @default.
- W4387517267 hasConcept C2780690907 @default.
- W4387517267 hasConcept C555293320 @default.
- W4387517267 hasConcept C71924100 @default.
- W4387517267 hasConcept C98274493 @default.
- W4387517267 hasConceptScore W4387517267C112705442 @default.
- W4387517267 hasConceptScore W4387517267C126322002 @default.
- W4387517267 hasConceptScore W4387517267C134018914 @default.
- W4387517267 hasConceptScore W4387517267C16005928 @default.
- W4387517267 hasConceptScore W4387517267C2778566413 @default.
- W4387517267 hasConceptScore W4387517267C2779091943 @default.
- W4387517267 hasConceptScore W4387517267C2779548794 @default.
- W4387517267 hasConceptScore W4387517267C2780272996 @default.
- W4387517267 hasConceptScore W4387517267C2780402444 @default.
- W4387517267 hasConceptScore W4387517267C2780690907 @default.
- W4387517267 hasConceptScore W4387517267C555293320 @default.
- W4387517267 hasConceptScore W4387517267C71924100 @default.
- W4387517267 hasConceptScore W4387517267C98274493 @default.
- W4387517267 hasLocation W43875172671 @default.
- W4387517267 hasLocation W43875172672 @default.
- W4387517267 hasOpenAccess W4387517267 @default.
- W4387517267 hasPrimaryLocation W43875172671 @default.
- W4387517267 hasRelatedWork W1968772793 @default.
- W4387517267 hasRelatedWork W1973282809 @default.
- W4387517267 hasRelatedWork W1990005834 @default.
- W4387517267 hasRelatedWork W2073989245 @default.
- W4387517267 hasRelatedWork W2079989445 @default.
- W4387517267 hasRelatedWork W2101343997 @default.
- W4387517267 hasRelatedWork W2151162411 @default.
- W4387517267 hasRelatedWork W2799470600 @default.
- W4387517267 hasRelatedWork W4288061029 @default.
- W4387517267 hasRelatedWork W4384929887 @default.
- W4387517267 isParatext "false" @default.
- W4387517267 isRetracted "false" @default.
- W4387517267 workType "article" @default.