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• W4387519105 abstract "Purpose To investigate the response to Acthar Gel® in patients with moderate to severe sarcoidosis uveitis. Methods This is a prospective open-label study that enrolled patients with moderate to severe sarcoidosis uveitis to receive 80 units daily of Acthar Gel for ten days followed by maintenance treatment with 80 units twice weekly. The primary outcome was the proportion of patients meeting at least one of the following variables 1) improved visual acuity, 2) resolution of intraocular inflammation, 3) ability to taper ocular or oral steroids by at least 50% or 4) reduction of cystoid macular edema, with no worsening of any single measure and no need for additional sarcoidosis therapies at 24 weeks. Results A total of nine patients were enrolled in the study. Four patients completed the full 24-week course of Acthar Gel, and three of these met the primary endpoint. Among the five patients who did not complete the 24-week course of treatment, four discontinued the treatment due to worsening ocular inflammation. One patient discontinued treatment due to severe adverse effects. The most common adverse effects were fluid retention (77%), insomnia (44%), hypertension (44%) and hyperglycemia (44%). Conclusions We observed a clinical response to Acthar Gel in some patients with moderate to severe sarcoidosis uveitis, but a substantial proportion either failed to respond or did not tolerate the therapy. These observations may serve as preliminary data for controlled trials of Acthar Gel, but they do not support its role prior to failure of other agents." @default.
• W4387519105 created "2023-10-12" @default.
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• W4387519105 date "2023-11-01" @default.
• W4387519105 modified "2023-10-16" @default.
• W4387519105 title "Response to Acthar Gel in sarcoidosis uveitis: A prospective open label study" @default.
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• W4387519105 doi "https://doi.org/10.1016/j.rmed.2023.107422" @default.
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