FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387520123> ?p ?o ?g. }

• W4387520123 abstract "Background Vitamin D is a steroid hormone, known to be involved in the pathogenesis of various neurodegenerative disorders, including Parkinson’s disease (PD). We aimed to clarify the relationship between hypovitaminosis D and the predisposition for PD and its clinical presentation. An additional aim was to examine the specific gene polymorphisms associated with vitamin D level. Material and methods Total level of 25(OH)-vitamin D (25(OH)D) was measured in serum of parkinsonian patients (n=113) and controls (n= 82) using a commercial immunoassay. Genetic analyses were performed using Taqman assays on Real Time PCR amplification system. Results Higher frequency of vitamin D deficiency (< 50 nmol/L) was observed in PD patients, compared to controls (40.7% and 23.2%, respectively, P=0.010). It was also a positive predictive marker of PD (OR, 2.27; 95% CI, 1.206-4.298; P<0.011). Significantly higher UPDRS (35.85±1.35 and 32.09 ± 0.99, respectively, P=0.023) and HY scores (2(1.5-2.5) and 1.5(1.0-2.0), respectively, P=0.005) were present in patients with 25(OH)D level < 50 nmol/L compared to patients with 25(OH)D level ≥ 50 nmol/L. Despite some trends observed, differences in allelic and genotypic distribution between controls and patients, as well as between subgroups, did not reach the level of significance (P>0.05). Conclusions Findings of this study confirm the hypothesis of a significant relationship between hypovitaminosis D and PD. We demonstrated higher prevalence of vitamin D deficiency in PD patients, as well as its predictive potential for the onset and progression of PD." @default.
• W4387520123 created "2023-10-12" @default.
• W4387520123 creator A5002623872 @default.
• W4387520123 creator A5003460835 @default.
• W4387520123 creator A5039490793 @default.
• W4387520123 creator A5039974997 @default.
• W4387520123 creator A5073676802 @default.
• W4387520123 creator A5082593343 @default.
• W4387520123 creator A5085568835 @default.
• W4387520123 date "2023-10-01" @default.
• W4387520123 modified "2023-10-15" @default.
• W4387520123 title "Vitamin D serum levels and vitamin D receptor genotype in patients with Parkinson's disease" @default.
• W4387520123 cites W1556668535 @default.
• W4387520123 cites W1705522586 @default.
• W4387520123 cites W1847168837 @default.
• W4387520123 cites W1970558060 @default.
• W4387520123 cites W1973792912 @default.
• W4387520123 cites W1988590383 @default.
• W4387520123 cites W1989554921 @default.
• W4387520123 cites W2032288122 @default.
• W4387520123 cites W2055140737 @default.
• W4387520123 cites W2064996887 @default.
• W4387520123 cites W2073449985 @default.
• W4387520123 cites W2084331979 @default.
• W4387520123 cites W2087211729 @default.
• W4387520123 cites W2088218392 @default.
• W4387520123 cites W2088610329 @default.
• W4387520123 cites W2094779143 @default.
• W4387520123 cites W2096640312 @default.
• W4387520123 cites W2101331374 @default.
• W4387520123 cites W2107962391 @default.
• W4387520123 cites W2109978145 @default.
• W4387520123 cites W2113591080 @default.
• W4387520123 cites W2114613490 @default.
• W4387520123 cites W2120241921 @default.
• W4387520123 cites W2120261841 @default.
• W4387520123 cites W2124070987 @default.
• W4387520123 cites W2140545678 @default.
• W4387520123 cites W2146594042 @default.
• W4387520123 cites W2153770089 @default.
• W4387520123 cites W2169422765 @default.
• W4387520123 cites W2238943778 @default.
• W4387520123 cites W2324955371 @default.
• W4387520123 cites W2760980623 @default.
• W4387520123 cites W2761954758 @default.
• W4387520123 cites W2887537550 @default.
• W4387520123 cites W2889683418 @default.
• W4387520123 cites W2901773446 @default.
• W4387520123 cites W2904404980 @default.
• W4387520123 cites W2914595728 @default.
• W4387520123 cites W2915473202 @default.
• W4387520123 cites W2966271885 @default.
• W4387520123 cites W3004916415 @default.
• W4387520123 cites W3081920050 @default.
• W4387520123 doi "https://doi.org/10.1016/j.neuroscience.2023.10.004" @default.
• W4387520123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37832907" @default.
• W4387520123 hasPublicationYear "2023" @default.
• W4387520123 type Work @default.
• W4387520123 citedByCount "0" @default.
• W4387520123 crossrefType "journal-article" @default.
• W4387520123 hasAuthorship W4387520123A5002623872 @default.
• W4387520123 hasAuthorship W4387520123A5003460835 @default.
• W4387520123 hasAuthorship W4387520123A5039490793 @default.
• W4387520123 hasAuthorship W4387520123A5039974997 @default.
• W4387520123 hasAuthorship W4387520123A5073676802 @default.
• W4387520123 hasAuthorship W4387520123A5082593343 @default.
• W4387520123 hasAuthorship W4387520123A5085568835 @default.
• W4387520123 hasConcept C104317684 @default.
• W4387520123 hasConcept C124490489 @default.
• W4387520123 hasConcept C126322002 @default.
• W4387520123 hasConcept C134018914 @default.
• W4387520123 hasConcept C135763542 @default.
• W4387520123 hasConcept C2778277197 @default.
• W4387520123 hasConcept C2779134260 @default.
• W4387520123 hasConcept C2779734285 @default.
• W4387520123 hasConcept C2779740938 @default.
• W4387520123 hasConcept C2780942790 @default.
• W4387520123 hasConcept C2781197716 @default.
• W4387520123 hasConcept C54355233 @default.
• W4387520123 hasConcept C71924100 @default.
• W4387520123 hasConcept C86803240 @default.
• W4387520123 hasConcept C90924648 @default.
• W4387520123 hasConceptScore W4387520123C104317684 @default.
• W4387520123 hasConceptScore W4387520123C124490489 @default.
• W4387520123 hasConceptScore W4387520123C126322002 @default.
• W4387520123 hasConceptScore W4387520123C134018914 @default.
• W4387520123 hasConceptScore W4387520123C135763542 @default.
• W4387520123 hasConceptScore W4387520123C2778277197 @default.
• W4387520123 hasConceptScore W4387520123C2779134260 @default.
• W4387520123 hasConceptScore W4387520123C2779734285 @default.
• W4387520123 hasConceptScore W4387520123C2779740938 @default.
• W4387520123 hasConceptScore W4387520123C2780942790 @default.
• W4387520123 hasConceptScore W4387520123C2781197716 @default.
• W4387520123 hasConceptScore W4387520123C54355233 @default.
• W4387520123 hasConceptScore W4387520123C71924100 @default.
• W4387520123 hasConceptScore W4387520123C86803240 @default.
• W4387520123 hasConceptScore W4387520123C90924648 @default.
• W4387520123 hasLocation W43875201231 @default.
• W4387520123 hasLocation W43875201232 @default.
• W4387520123 hasOpenAccess W4387520123 @default.

• next