FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387520736> ?p ?o ?g. }

• W4387520736 endingPage "10.1212/WNL.0000000000207844" @default.
• W4387520736 startingPage "10.1212/WNL.0000000000207844" @default.
• W4387520736 abstract "Background and Objectives: To determine the relevance of minor neuropsychological deficits (MNPD) in patients with subjective cognitive decline (SCD) with regard to CSF levels of Alzheimer’s disease (AD) biomarkers, cognitive decline and clinical progression to mild cognitive impairment (MCI). Methods: This study included clinical SCD patients and SCD free, healthy control (HC) participants with available baseline CSF and/or longitudinal cognitive data from the observational DZNE Longitudinal Cognitive Impairment and Dementia (DELCODE) study. We defined MNPD as a performance of at least 0.5SD below the mean on a demographically adjusted total score derived from the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery. We compared SCD patients with MNPD and those without MNPD with regard to CSF amyloid-β (Aβ)42/Aβ40, phosphorylated tau (p-tau 181 ) , total tau and Aβ42/p-tau 181 levels, longitudinal cognitive composite trajectories and risk of clinical progression to incident MCI (follow-up M ± SD : 40.6±23.7 months). Additionally, we explored group differences between SCD and HC in those without MNPD. Results: In our sample (N = 672, mean age: 70.7±5.9 years, 50% female), SCD patients with MNPD (n = 55, 12.5% of SCD group) showed significantly more abnormal CSF biomarker levels, increased cognitive decline and a higher risk of progression to incident MCI (HR: 4.07, 95%CI: 2.46-6.74) compared to SCD patients without MNPD (n = 384). MNPD had a positive predictive value of 57.0% (95%CI: 38.5-75.4) and a negative predictive value of 86.0% (95%CI: 81.9-90.1) for the progression of SCD to MCI within three years. SCD patients without MNPD showed increased cognitive decline and a higher risk of incident MCI compared to HC participants without MNPD (n = 215; HR: 4.09, 95%CI: 2.07-8.09), while AD biomarker levels did not differ significantly between these groups. Discussion: Our results suggest that MNPD are a risk factor for AD related clinical progression in cognitively normal patients seeking medical counseling due to SCD. As such, the assessment of MNPD could be useful for individual clinical prediction and for AD risk stratification in clinical trials. However, SCD remains a risk factor for future cognitive decline even in the absence of MNPD." @default.
• W4387520736 created "2023-10-12" @default.
• W4387520736 creator A5000608836 @default.
• W4387520736 creator A5007801159 @default.
• W4387520736 creator A5008716299 @default.
• W4387520736 creator A5010076581 @default.
• W4387520736 creator A5013040609 @default.
• W4387520736 creator A5015892420 @default.
• W4387520736 creator A5019564409 @default.
• W4387520736 creator A5021920622 @default.
• W4387520736 creator A5026015195 @default.
• W4387520736 creator A5026513335 @default.
• W4387520736 creator A5027958984 @default.
• W4387520736 creator A5029253897 @default.
• W4387520736 creator A5030220194 @default.
• W4387520736 creator A5041198772 @default.
• W4387520736 creator A5044675598 @default.
• W4387520736 creator A5045721609 @default.
• W4387520736 creator A5047702268 @default.
• W4387520736 creator A5048074007 @default.
• W4387520736 creator A5048249357 @default.
• W4387520736 creator A5049386810 @default.
• W4387520736 creator A5050028517 @default.
• W4387520736 creator A5053381812 @default.
• W4387520736 creator A5055109212 @default.
• W4387520736 creator A5057582966 @default.
• W4387520736 creator A5058720451 @default.
• W4387520736 creator A5062703349 @default.
• W4387520736 creator A5065253382 @default.
• W4387520736 creator A5069022559 @default.
• W4387520736 creator A5069402695 @default.
• W4387520736 creator A5069577796 @default.
• W4387520736 creator A5075596948 @default.
• W4387520736 creator A5076331208 @default.
• W4387520736 creator A5076785118 @default.
• W4387520736 creator A5078351917 @default.
• W4387520736 creator A5078440867 @default.
• W4387520736 creator A5078895221 @default.
• W4387520736 creator A5079896442 @default.
• W4387520736 creator A5080049532 @default.
• W4387520736 creator A5083929047 @default.
• W4387520736 creator A5087655756 @default.
• W4387520736 creator A5087981113 @default.
• W4387520736 creator A5091186958 @default.
• W4387520736 creator A5092623504 @default.
• W4387520736 date "2023-10-11" @default.
• W4387520736 modified "2023-10-13" @default.
• W4387520736 title "Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline" @default.
• W4387520736 doi "https://doi.org/10.1212/wnl.0000000000207844" @default.
• W4387520736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37821235" @default.
• W4387520736 hasPublicationYear "2023" @default.
• W4387520736 type Work @default.
• W4387520736 citedByCount "0" @default.
• W4387520736 crossrefType "journal-article" @default.
• W4387520736 hasAuthorship W4387520736A5000608836 @default.
• W4387520736 hasAuthorship W4387520736A5007801159 @default.
• W4387520736 hasAuthorship W4387520736A5008716299 @default.
• W4387520736 hasAuthorship W4387520736A5010076581 @default.
• W4387520736 hasAuthorship W4387520736A5013040609 @default.
• W4387520736 hasAuthorship W4387520736A5015892420 @default.
• W4387520736 hasAuthorship W4387520736A5019564409 @default.
• W4387520736 hasAuthorship W4387520736A5021920622 @default.
• W4387520736 hasAuthorship W4387520736A5026015195 @default.
• W4387520736 hasAuthorship W4387520736A5026513335 @default.
• W4387520736 hasAuthorship W4387520736A5027958984 @default.
• W4387520736 hasAuthorship W4387520736A5029253897 @default.
• W4387520736 hasAuthorship W4387520736A5030220194 @default.
• W4387520736 hasAuthorship W4387520736A5041198772 @default.
• W4387520736 hasAuthorship W4387520736A5044675598 @default.
• W4387520736 hasAuthorship W4387520736A5045721609 @default.
• W4387520736 hasAuthorship W4387520736A5047702268 @default.
• W4387520736 hasAuthorship W4387520736A5048074007 @default.
• W4387520736 hasAuthorship W4387520736A5048249357 @default.
• W4387520736 hasAuthorship W4387520736A5049386810 @default.
• W4387520736 hasAuthorship W4387520736A5050028517 @default.
• W4387520736 hasAuthorship W4387520736A5053381812 @default.
• W4387520736 hasAuthorship W4387520736A5055109212 @default.
• W4387520736 hasAuthorship W4387520736A5057582966 @default.
• W4387520736 hasAuthorship W4387520736A5058720451 @default.
• W4387520736 hasAuthorship W4387520736A5062703349 @default.
• W4387520736 hasAuthorship W4387520736A5065253382 @default.
• W4387520736 hasAuthorship W4387520736A5069022559 @default.
• W4387520736 hasAuthorship W4387520736A5069402695 @default.
• W4387520736 hasAuthorship W4387520736A5069577796 @default.
• W4387520736 hasAuthorship W4387520736A5075596948 @default.
• W4387520736 hasAuthorship W4387520736A5076331208 @default.
• W4387520736 hasAuthorship W4387520736A5076785118 @default.
• W4387520736 hasAuthorship W4387520736A5078351917 @default.
• W4387520736 hasAuthorship W4387520736A5078440867 @default.
• W4387520736 hasAuthorship W4387520736A5078895221 @default.
• W4387520736 hasAuthorship W4387520736A5079896442 @default.
• W4387520736 hasAuthorship W4387520736A5080049532 @default.
• W4387520736 hasAuthorship W4387520736A5083929047 @default.
• W4387520736 hasAuthorship W4387520736A5087655756 @default.
• W4387520736 hasAuthorship W4387520736A5087981113 @default.
• W4387520736 hasAuthorship W4387520736A5091186958 @default.
• W4387520736 hasAuthorship W4387520736A5092623504 @default.
• W4387520736 hasBestOaLocation W43875207361 @default.

• next