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• W4387526412 endingPage "e1010975" @default.
• W4387526412 startingPage "e1010975" @default.
• W4387526412 abstract "WNK (With no Lysine [K]) kinases have critical roles in the maintenance of ion homeostasis and the regulation of cell volume. Their overactivation leads to pseudohypoaldosteronism type II (Gordon syndrome) characterized by hyperkalemia and high blood pressure. More recently, WNK family members have been shown to be required for the development of the nervous system in mice, zebrafish, and flies, and the cardiovascular system of mice and fish. Furthermore, human WNK2 and Drosophila Wnk modulate canonical Wnt signaling. In addition to a well-conserved kinase domain, animal WNKs have a large, poorly conserved C-terminal domain whose function has been largely mysterious. In most but not all cases, WNKs bind and activate downstream kinases OSR1/SPAK, which in turn regulate the activity of various ion transporters and channels. Here, we show that Drosophila Wnk regulates Wnt signaling and cell size during the development of the wing in a manner dependent on Fray, the fly homolog of OSR1/SPAK. We show that the only canonical RF(X)V/I motif of Wnk, thought to be essential for WNK interactions with OSR1/SPAK, is required to interact with Fray in vitro. However, this motif is unexpectedly dispensable for Fray-dependent Wnk functions in vivo during fly development and fluid secretion in the Malpigian (renal) tubules. In contrast, a structure function analysis of Wnk revealed that the less-conserved C-terminus of Wnk, that recently has been shown to promote phase transitions in cell culture, is required for viability in vivo. Our data thus provide novel insights into unexpected in vivo roles of specific WNK domains." @default.
• W4387526412 created "2023-10-12" @default.
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• W4387526412 date "2023-10-11" @default.
• W4387526412 modified "2023-10-18" @default.
• W4387526412 title "Unanticipated domain requirements for Drosophila Wnk kinase in vivo" @default.
• W4387526412 cites W1008499258 @default.
• W4387526412 cites W1828818916 @default.
• W4387526412 cites W1969444351 @default.
• W4387526412 cites W1970685853 @default.
• W4387526412 cites W1972023043 @default.
• W4387526412 cites W1973469920 @default.
• W4387526412 cites W1975016763 @default.
• W4387526412 cites W1976499406 @default.
• W4387526412 cites W1978524347 @default.
• W4387526412 cites W1978652875 @default.
• W4387526412 cites W1985710176 @default.
• W4387526412 cites W1986344181 @default.
• W4387526412 cites W1989082283 @default.
• W4387526412 cites W1993043495 @default.
• W4387526412 cites W1998356880 @default.
• W4387526412 cites W1999348922 @default.
• W4387526412 cites W2016240460 @default.
• W4387526412 cites W2018671384 @default.
• W4387526412 cites W2024805055 @default.
• W4387526412 cites W2025447591 @default.
• W4387526412 cites W2027895266 @default.
• W4387526412 cites W2041523748 @default.
• W4387526412 cites W2041753387 @default.
• W4387526412 cites W2042819884 @default.
• W4387526412 cites W2042916215 @default.
• W4387526412 cites W2046070694 @default.
• W4387526412 cites W2052112605 @default.
• W4387526412 cites W2052539926 @default.
• W4387526412 cites W2053043900 @default.
• W4387526412 cites W2057416614 @default.
• W4387526412 cites W2064858398 @default.
• W4387526412 cites W2065452898 @default.
• W4387526412 cites W2072543436 @default.
• W4387526412 cites W2074270298 @default.
• W4387526412 cites W2077220677 @default.
• W4387526412 cites W2079156404 @default.
• W4387526412 cites W2090456972 @default.
• W4387526412 cites W2093501846 @default.
• W4387526412 cites W2094353154 @default.
• W4387526412 cites W2105277147 @default.
• W4387526412 cites W2109695507 @default.
• W4387526412 cites W2119887502 @default.
• W4387526412 cites W2129352375 @default.
• W4387526412 cites W2133185088 @default.
• W4387526412 cites W2133770158 @default.
• W4387526412 cites W2135394966 @default.
• W4387526412 cites W2141617464 @default.
• W4387526412 cites W2142766228 @default.
• W4387526412 cites W2146497623 @default.
• W4387526412 cites W2146920291 @default.
• W4387526412 cites W2148617989 @default.
• W4387526412 cites W2150380575 @default.
• W4387526412 cites W2151326362 @default.
• W4387526412 cites W2154395280 @default.
• W4387526412 cites W2162642974 @default.
• W4387526412 cites W2166384825 @default.
• W4387526412 cites W2167279371 @default.
• W4387526412 cites W2168248904 @default.
• W4387526412 cites W2172151601 @default.
• W4387526412 cites W2175733696 @default.
• W4387526412 cites W2296632437 @default.
• W4387526412 cites W2309489548 @default.
• W4387526412 cites W2400847670 @default.
• W4387526412 cites W2402498701 @default.
• W4387526412 cites W2526278979 @default.
• W4387526412 cites W2789775073 @default.
• W4387526412 cites W2794452052 @default.
• W4387526412 cites W2809083305 @default.
• W4387526412 cites W2888798024 @default.
• W4387526412 cites W2898204371 @default.
• W4387526412 cites W2916609949 @default.
• W4387526412 cites W2991073053 @default.
• W4387526412 cites W3094364909 @default.
• W4387526412 cites W3100148348 @default.
• W4387526412 cites W3185550380 @default.
• W4387526412 cites W4205574177 @default.
• W4387526412 cites W4221075565 @default.
• W4387526412 cites W4221108730 @default.
• W4387526412 doi "https://doi.org/10.1371/journal.pgen.1010975" @default.
• W4387526412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37819975" @default.
• W4387526412 hasPublicationYear "2023" @default.

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