Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387527376> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4387527376 abstract "Critical Gram-negative pathogens, like Pseudomonas, Stenotrophomonas and Burkholderia, have become resistant to most antibiotics. Complex resistance profiles together with synergistic interactions between these organisms increase the likelihood of treatment failure in distinct infection settings, for example in the lungs of cystic fibrosis patients. Here, we discover that cell envelope protein homeostasis pathways underpin both antibiotic resistance and cross-protection in CF-associated bacteria. We find that inhibition of oxidative protein folding inactivates multiple species-specific resistance proteins. Using this strategy, we sensitize multi-drug resistant Pseudomonas aeruginosa to β-lactam antibiotics and demonstrate promise of new treatment avenues for the recalcitrant pathogen Stenotrophomonas maltophilia. The same approach also inhibits cross-protection between resistant S. maltophilia and susceptible P. aeruginosa, allowing eradication of both commonly co-occurring CF-associated organisms. Our results provide the basis for the development of next-generation strategies that target antibiotic resistance, while also impairing specific interbacterial interactions that enhance the severity of polymicrobial infections." @default.
- W4387527376 created "2023-10-12" @default.
- W4387527376 date "2023-10-11" @default.
- W4387527376 modified "2023-10-12" @default.
- W4387527376 title "Reviewer #1 (Public Review): Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis" @default.
- W4387527376 doi "https://doi.org/10.7554/elife.91082.1.sa1" @default.
- W4387527376 hasPublicationYear "2023" @default.
- W4387527376 type Work @default.
- W4387527376 citedByCount "0" @default.
- W4387527376 crossrefType "peer-review" @default.
- W4387527376 hasBestOaLocation W43875273761 @default.
- W4387527376 hasConcept C114851261 @default.
- W4387527376 hasConcept C136622501 @default.
- W4387527376 hasConcept C19655278 @default.
- W4387527376 hasConcept C2776352461 @default.
- W4387527376 hasConcept C2776460866 @default.
- W4387527376 hasConcept C2776938444 @default.
- W4387527376 hasConcept C2777287306 @default.
- W4387527376 hasConcept C2777637488 @default.
- W4387527376 hasConcept C2780183148 @default.
- W4387527376 hasConcept C2780855054 @default.
- W4387527376 hasConcept C2781463711 @default.
- W4387527376 hasConcept C501593827 @default.
- W4387527376 hasConcept C523546767 @default.
- W4387527376 hasConcept C54355233 @default.
- W4387527376 hasConcept C58123911 @default.
- W4387527376 hasConcept C86803240 @default.
- W4387527376 hasConcept C89423630 @default.
- W4387527376 hasConcept C94665300 @default.
- W4387527376 hasConceptScore W4387527376C114851261 @default.
- W4387527376 hasConceptScore W4387527376C136622501 @default.
- W4387527376 hasConceptScore W4387527376C19655278 @default.
- W4387527376 hasConceptScore W4387527376C2776352461 @default.
- W4387527376 hasConceptScore W4387527376C2776460866 @default.
- W4387527376 hasConceptScore W4387527376C2776938444 @default.
- W4387527376 hasConceptScore W4387527376C2777287306 @default.
- W4387527376 hasConceptScore W4387527376C2777637488 @default.
- W4387527376 hasConceptScore W4387527376C2780183148 @default.
- W4387527376 hasConceptScore W4387527376C2780855054 @default.
- W4387527376 hasConceptScore W4387527376C2781463711 @default.
- W4387527376 hasConceptScore W4387527376C501593827 @default.
- W4387527376 hasConceptScore W4387527376C523546767 @default.
- W4387527376 hasConceptScore W4387527376C54355233 @default.
- W4387527376 hasConceptScore W4387527376C58123911 @default.
- W4387527376 hasConceptScore W4387527376C86803240 @default.
- W4387527376 hasConceptScore W4387527376C89423630 @default.
- W4387527376 hasConceptScore W4387527376C94665300 @default.
- W4387527376 hasLocation W43875273761 @default.
- W4387527376 hasOpenAccess W4387527376 @default.
- W4387527376 hasPrimaryLocation W43875273761 @default.
- W4387527376 hasRelatedWork W1966366103 @default.
- W4387527376 hasRelatedWork W2104071021 @default.
- W4387527376 hasRelatedWork W2140715227 @default.
- W4387527376 hasRelatedWork W2239019731 @default.
- W4387527376 hasRelatedWork W2501566056 @default.
- W4387527376 hasRelatedWork W2744097980 @default.
- W4387527376 hasRelatedWork W2777184831 @default.
- W4387527376 hasRelatedWork W2799914279 @default.
- W4387527376 hasRelatedWork W3023239933 @default.
- W4387527376 hasRelatedWork W3186531598 @default.
- W4387527376 isParatext "false" @default.
- W4387527376 isRetracted "false" @default.
- W4387527376 workType "peer-review" @default.