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- W4387527992 abstract "Many systemically administered cancer therapies exhibit dose-limiting toxicities that reduce their effectiveness. To increase efficacy, bacterial delivery platforms have been developed that improve safety and prolong treatment. Bacteria are a unique class of therapy that selectively colonizes most solid tumors. As delivery vehicles, bacteria have been genetically modified to express a range of therapies that match multiple cancer indications. In this review, we describe a modular “build-a-bug” method that focuses on five design characteristics: bacterial strain (chassis), therapeutic compound, delivery method, immune-modulating features, and genetic control circuits. We emphasize how fundamental research into gut microbe pathogenesis has created safe bacterial therapies, some of which have entered clinical trials. The genomes of gut microbes are fertile grounds for discovery of components to improve delivery and modulate host immune responses. Future work coupling these delivery vehicles with insights from gut microbes could lead to the next generation of microbial cancer therapy." @default.
- W4387527992 created "2023-10-12" @default.
- W4387527992 creator A5035000599 @default.
- W4387527992 creator A5063006710 @default.
- W4387527992 creator A5082122104 @default.
- W4387527992 creator A5084433637 @default.
- W4387527992 creator A5088161063 @default.
- W4387527992 creator A5093042271 @default.
- W4387527992 date "2023-10-01" @default.
- W4387527992 modified "2023-10-14" @default.
- W4387527992 title "Build-a-bug workshop: Using microbial-host interactions and synthetic biology tools to create cancer therapies" @default.
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