Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387529055> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4387529055 abstract "Background and Purpose: Erectile dysfunction (ED) is an indicator for futurecardiovascular events. The search for new targets is crucial due to the low efficacy ofPDE5 inhibitors in patients with endothelial dysfunction. Menthol, a TRPM8 agonist, iswidely used in preparations to improve sensation during sexual intercourse, although nodata are reported for the improvement of ED. So, we hypothesize that chronic topicalactivation of TRPM8 improves hypertension associated-ED. Experimental Approach: Adult (9-12 weeks) male spontaneously hypertensive rats (SHR) and Wistar rats wereused for protein expression analysis and TRPM8 agonist curves in isolated CC. We alsotreated rats topically on the penis for 30 days with carbopol 940 (hydrogel, vehicle) ormenthol (carbopol 940 + menthol 0.1%). After treatment, we measured the mean bloodpressure (MBP), CC and iliac (IL) artery contractility. Key Results: Both strains of rathad similar TRPM8 expression in CC by western blotting and immunofluorescence.TRPM8 activation by cooling compounds, icilin (10 -8 –10 -4 M) or menthol (10 -7 –10 -3 M),relaxed CC strips pre-contracted by phenylephrine (PE, 10 -6 or 10 -5 M), but with reducedeffect in SHR. Interestingly, the topical penile treatment with menthol decreased the MBPof the SHR (151.8±6.8 mmHg, n=6) compared to the SHR vehicle group (174.6±2.6mmHg, n=5; p<0.05). In addition, in CC, the concentration-response curves to PE andthromboxane agonists were shifted to the left after menthol treatment. Interestingly, nochange in acetylcholine and sodium nitroprusside (SNP) relaxation were observed aftertopical penile treatment with menthol. The concentration-response curves to PE and SNPwere shifted to the left in IL arterial rings. This suggests topical menthol administrationinduced systemic vascular influence leading to a response like the normotensive Wistar. Conclusion: TRPM8 channels are expressed and functional in the CC, with decreasedsensitivity in SHR. Also, our data suggest that topical administration of menthol improvesthe reactivity of vascular tissue, demonstrating the potential of TRPM8 activation fortherapeutic benefits in hypertension associated-ED." @default.
- W4387529055 created "2023-10-12" @default.
- W4387529055 creator A5020201878 @default.
- W4387529055 creator A5022191748 @default.
- W4387529055 creator A5028268961 @default.
- W4387529055 creator A5030845503 @default.
- W4387529055 creator A5039750907 @default.
- W4387529055 creator A5077387542 @default.
- W4387529055 creator A5091176749 @default.
- W4387529055 date "2023-09-01" @default.
- W4387529055 modified "2023-10-12" @default.
- W4387529055 title "Abstract P229: Beyond Cooling Sensation: Topical Penile Administration Of The Trpm8 Agonist Improves Hypertension Associated-erectile Dysfunction" @default.
- W4387529055 doi "https://doi.org/10.1161/hyp.80.suppl_1.p229" @default.
- W4387529055 hasPublicationYear "2023" @default.
- W4387529055 type Work @default.
- W4387529055 citedByCount "0" @default.
- W4387529055 crossrefType "journal-article" @default.
- W4387529055 hasAuthorship W4387529055A5020201878 @default.
- W4387529055 hasAuthorship W4387529055A5022191748 @default.
- W4387529055 hasAuthorship W4387529055A5028268961 @default.
- W4387529055 hasAuthorship W4387529055A5030845503 @default.
- W4387529055 hasAuthorship W4387529055A5039750907 @default.
- W4387529055 hasAuthorship W4387529055A5077387542 @default.
- W4387529055 hasAuthorship W4387529055A5091176749 @default.
- W4387529055 hasConcept C126322002 @default.
- W4387529055 hasConcept C134018914 @default.
- W4387529055 hasConcept C141071460 @default.
- W4387529055 hasConcept C155164980 @default.
- W4387529055 hasConcept C160145004 @default.
- W4387529055 hasConcept C163146387 @default.
- W4387529055 hasConcept C170493617 @default.
- W4387529055 hasConcept C178790620 @default.
- W4387529055 hasConcept C185592680 @default.
- W4387529055 hasConcept C2777786686 @default.
- W4387529055 hasConcept C2777952589 @default.
- W4387529055 hasConcept C2778938600 @default.
- W4387529055 hasConcept C2779610285 @default.
- W4387529055 hasConcept C2779929075 @default.
- W4387529055 hasConcept C2780194911 @default.
- W4387529055 hasConcept C2780972559 @default.
- W4387529055 hasConcept C42219234 @default.
- W4387529055 hasConcept C519581460 @default.
- W4387529055 hasConcept C71924100 @default.
- W4387529055 hasConcept C84393581 @default.
- W4387529055 hasConcept C98274493 @default.
- W4387529055 hasConceptScore W4387529055C126322002 @default.
- W4387529055 hasConceptScore W4387529055C134018914 @default.
- W4387529055 hasConceptScore W4387529055C141071460 @default.
- W4387529055 hasConceptScore W4387529055C155164980 @default.
- W4387529055 hasConceptScore W4387529055C160145004 @default.
- W4387529055 hasConceptScore W4387529055C163146387 @default.
- W4387529055 hasConceptScore W4387529055C170493617 @default.
- W4387529055 hasConceptScore W4387529055C178790620 @default.
- W4387529055 hasConceptScore W4387529055C185592680 @default.
- W4387529055 hasConceptScore W4387529055C2777786686 @default.
- W4387529055 hasConceptScore W4387529055C2777952589 @default.
- W4387529055 hasConceptScore W4387529055C2778938600 @default.
- W4387529055 hasConceptScore W4387529055C2779610285 @default.
- W4387529055 hasConceptScore W4387529055C2779929075 @default.
- W4387529055 hasConceptScore W4387529055C2780194911 @default.
- W4387529055 hasConceptScore W4387529055C2780972559 @default.
- W4387529055 hasConceptScore W4387529055C42219234 @default.
- W4387529055 hasConceptScore W4387529055C519581460 @default.
- W4387529055 hasConceptScore W4387529055C71924100 @default.
- W4387529055 hasConceptScore W4387529055C84393581 @default.
- W4387529055 hasConceptScore W4387529055C98274493 @default.
- W4387529055 hasIssue "Suppl_1" @default.
- W4387529055 hasLocation W43875290551 @default.
- W4387529055 hasOpenAccess W4387529055 @default.
- W4387529055 hasPrimaryLocation W43875290551 @default.
- W4387529055 hasRelatedWork W1974195039 @default.
- W4387529055 hasRelatedWork W2027859599 @default.
- W4387529055 hasRelatedWork W2091804831 @default.
- W4387529055 hasRelatedWork W2135844166 @default.
- W4387529055 hasRelatedWork W2192033545 @default.
- W4387529055 hasRelatedWork W2590814612 @default.
- W4387529055 hasRelatedWork W3013148407 @default.
- W4387529055 hasRelatedWork W3167269973 @default.
- W4387529055 hasRelatedWork W4283204639 @default.
- W4387529055 hasRelatedWork W4377020009 @default.
- W4387529055 hasVolume "80" @default.
- W4387529055 isParatext "false" @default.
- W4387529055 isRetracted "false" @default.
- W4387529055 workType "article" @default.