FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387529198> ?p ?o ?g. }

• W4387529198 abstract "Hypertension, a major cause of premature death worldwide, is more prevalent in postmenopausal women compared to premenopausal women. Data implicate a protective effect of G protein-coupled estrogen receptor 1 (GPER1) in cardiovascular diseases. A recent study showed that previous pregnancy lowers blood pressure in hyperandrogenemic rats. We hypothesized that pregnancy protects against hypertension elicited in aged female mice lacking GPER1. 16-20 month-old GPER1 wild-type (WT) and knock-out (KO) mice with or without a history of former pregnancies were implanted with telemeters for blood pressure recording and placed in metabolic cages for 24h urine collection. Plasma, adrenal glands and kidneys were collected. GPER1 deletion increased mean arterial pressure in virgin mice (125±3 vs. 109±2 mmHg; n=3,7; p=0.0005), and previous pregnancies (PP) eliminated this genotypic effect (106±1 mmHg; n=6; p≤0.0001). Aldosterone plays a critical role in blood pressure regulation, we measured its urinary excretion and revealed lower levels in PP KO mice compared to virgin KO mice (4.8±0.8 vs. 13.0±3.0 pg/day; n=6; p=0.0099). PP KO mice elicited greater levels of circulating estradiol levels compared to virgin KO mice (42.8±5.2 vs. 29.5±3.4 pg/mL; n=8,6; p=0.0451). To explore the role of adrenal estrogen receptors (ER) in regulating aldosterone production, we assessed the adrenal expression of ER and CYP112B, the gene coding for aldosterone synthase. No difference was observed in ERα, however ERβ expression was higher in PP KO mice compared to virgin KO mice (2.4±0.3 vs. 1.1±0.1 fold change; n=6,5; p=0.0359). GPER1 deletion increased CYP112B expression in virgin mice (2.0±0.4 vs. 1.0±0.2 fold change; n=7,5; p=0.0265), and this was eliminated with PP (0.9±0.2 fold change; n=5; p=0.0260). Aldosterone regulates renal epithelial sodium channel (ENaC), so we assessed its subunits’ expression. Renal ENaCα and ENaCβ increases with the deletion of GPER1 in the virgin group, and this effect was lost with PP. ENaCγ withheld the same trend, but it did not reach significance. Overal, our data suggest that GPER1 and former pregnancy protect from hypertension in aged females at least partially via regulating aldosterone and ENaC signaling." @default.
• W4387529198 created "2023-10-12" @default.
• W4387529198 creator A5006342556 @default.
• W4387529198 creator A5044059244 @default.
• W4387529198 creator A5056838679 @default.
• W4387529198 creator A5070878597 @default.
• W4387529198 date "2023-09-01" @default.
• W4387529198 modified "2023-10-12" @default.
• W4387529198 title "Abstract 063: Pregnancy Protects Aged G Protein-coupled Estrogen Receptor 1 Knock-out Mice Against Hypertension" @default.
• W4387529198 doi "https://doi.org/10.1161/hyp.80.suppl_1.063" @default.
• W4387529198 hasPublicationYear "2023" @default.
• W4387529198 type Work @default.
• W4387529198 citedByCount "0" @default.
• W4387529198 crossrefType "journal-article" @default.
• W4387529198 hasAuthorship W4387529198A5006342556 @default.
• W4387529198 hasAuthorship W4387529198A5044059244 @default.
• W4387529198 hasAuthorship W4387529198A5056838679 @default.
• W4387529198 hasAuthorship W4387529198A5070878597 @default.
• W4387529198 hasConcept C10146269 @default.
• W4387529198 hasConcept C121608353 @default.
• W4387529198 hasConcept C126322002 @default.
• W4387529198 hasConcept C134018914 @default.
• W4387529198 hasConcept C198710026 @default.
• W4387529198 hasConcept C2777164284 @default.
• W4387529198 hasConcept C2778525890 @default.
• W4387529198 hasConcept C2779234561 @default.
• W4387529198 hasConcept C2780249997 @default.
• W4387529198 hasConcept C530470458 @default.
• W4387529198 hasConcept C54355233 @default.
• W4387529198 hasConcept C71924100 @default.
• W4387529198 hasConcept C84393581 @default.
• W4387529198 hasConcept C84606932 @default.
• W4387529198 hasConcept C86803240 @default.
• W4387529198 hasConceptScore W4387529198C10146269 @default.
• W4387529198 hasConceptScore W4387529198C121608353 @default.
• W4387529198 hasConceptScore W4387529198C126322002 @default.
• W4387529198 hasConceptScore W4387529198C134018914 @default.
• W4387529198 hasConceptScore W4387529198C198710026 @default.
• W4387529198 hasConceptScore W4387529198C2777164284 @default.
• W4387529198 hasConceptScore W4387529198C2778525890 @default.
• W4387529198 hasConceptScore W4387529198C2779234561 @default.
• W4387529198 hasConceptScore W4387529198C2780249997 @default.
• W4387529198 hasConceptScore W4387529198C530470458 @default.
• W4387529198 hasConceptScore W4387529198C54355233 @default.
• W4387529198 hasConceptScore W4387529198C71924100 @default.
• W4387529198 hasConceptScore W4387529198C84393581 @default.
• W4387529198 hasConceptScore W4387529198C84606932 @default.
• W4387529198 hasConceptScore W4387529198C86803240 @default.
• W4387529198 hasIssue "Suppl_1" @default.
• W4387529198 hasLocation W43875291981 @default.
• W4387529198 hasOpenAccess W4387529198 @default.
• W4387529198 hasPrimaryLocation W43875291981 @default.
• W4387529198 hasRelatedWork W1126044527 @default.
• W4387529198 hasRelatedWork W1980559609 @default.
• W4387529198 hasRelatedWork W2152585030 @default.
• W4387529198 hasRelatedWork W2153642659 @default.
• W4387529198 hasRelatedWork W2172016508 @default.
• W4387529198 hasRelatedWork W2387467656 @default.
• W4387529198 hasRelatedWork W3015296784 @default.
• W4387529198 hasRelatedWork W4233585818 @default.
• W4387529198 hasRelatedWork W4286924426 @default.
• W4387529198 hasRelatedWork W4387029251 @default.
• W4387529198 hasVolume "80" @default.
• W4387529198 isParatext "false" @default.
• W4387529198 isRetracted "false" @default.
• W4387529198 workType "article" @default.