FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387530817> ?p ?o ?g. }

• W4387530817 abstract "This current study reports, for the first time, on the potent cytotoxicity of (Z)-3-hexenyl-β-D-glucopyranoside, as well as its cellular and molecular apoptotic mechanisms against Panc1 cancer cells. The cytotoxicity of three compounds, namely (Z)-3-hexenyl-β-D-glucopyranoside (1), gallic acid (2), and pyrogallol (3), which were isolated from C. rotang leaf, was investigated against certain cancer and normal cells using the MTT assay. The cellular apoptotic activity and Panc1 cell cycle impact of compound (1) were examined through flow cytometry analysis and Annexin V-FITC cellular apoptotic assays. Additionally, RT-PCR was employed to evaluate the effect of compound (1) on the Panc1 apoptotic genes Casp3 and Bax, as well as the antiapoptotic gene Bcl-2. (Z)-3-hexenyl-β-D-glucopyranoside demonstrated the highest cytotoxic activity against Panc1 cancer cells, with an IC50 value of 7.6 µM. In comparison, gallic acid exhibited an IC50 value of 21.8 µM, and pyrogallol showed an IC50 value of 198.2 µM. However, (Z)-3-hexenyl-β-D-glucopyranoside displayed minimal or no significant cytotoxic activity against HepG2 and MCF7 cancer cells as well as WI-38 normal cells, with IC50 values of 45.8 µM, 108.7 µM, and 194. µM, respectively. (Z)-3-hexenyl-β-D-glucopyranoside (10 µM) was demonstrated to induce cellular apoptosis and cell growth arrest at the S phase of the cell cycle in Panc1 cells. These findings were supported by RT-PCR analysis, which revealed the upregulation of apoptotic genes (Casp3 and Bax) and the downregulation of the antiapoptotic gene Bcl-2. This study emphasizes the significant cellular potency of (Z)-3-hexenyl-β-D-glucopyranoside in specifically inducing cytotoxicity in Panc1 cells." @default.
• W4387530817 created "2023-10-12" @default.
• W4387530817 creator A5009224694 @default.
• W4387530817 creator A5025060135 @default.
• W4387530817 creator A5037945875 @default.
• W4387530817 creator A5087863289 @default.
• W4387530817 date "2023-10-11" @default.
• W4387530817 modified "2023-10-18" @default.
• W4387530817 title "Potent anticancer activity of (Z)-3-hexenyl-β-D-glucopyranoside in pancreatic cancer cells" @default.
• W4387530817 cites W125106425 @default.
• W4387530817 cites W1631351150 @default.
• W4387530817 cites W1866211782 @default.
• W4387530817 cites W1996860534 @default.
• W4387530817 cites W1996902469 @default.
• W4387530817 cites W2003270672 @default.
• W4387530817 cites W2024792483 @default.
• W4387530817 cites W2028848055 @default.
• W4387530817 cites W2029567035 @default.
• W4387530817 cites W2034007388 @default.
• W4387530817 cites W2036711926 @default.
• W4387530817 cites W2045563337 @default.
• W4387530817 cites W2047926743 @default.
• W4387530817 cites W2048415138 @default.
• W4387530817 cites W2071768186 @default.
• W4387530817 cites W2073725745 @default.
• W4387530817 cites W2077883803 @default.
• W4387530817 cites W2086113348 @default.
• W4387530817 cites W2150304518 @default.
• W4387530817 cites W2263971776 @default.
• W4387530817 cites W2614062503 @default.
• W4387530817 cites W2735361421 @default.
• W4387530817 cites W2800389517 @default.
• W4387530817 cites W2803441813 @default.
• W4387530817 cites W2888491462 @default.
• W4387530817 cites W2936786597 @default.
• W4387530817 cites W2947389504 @default.
• W4387530817 cites W2976410240 @default.
• W4387530817 cites W2984847508 @default.
• W4387530817 cites W3005202820 @default.
• W4387530817 cites W3082738322 @default.
• W4387530817 cites W3211873255 @default.
• W4387530817 cites W4200394407 @default.
• W4387530817 cites W4205677032 @default.
• W4387530817 cites W4240479615 @default.
• W4387530817 cites W4327849144 @default.
• W4387530817 cites W198376462 @default.
• W4387530817 doi "https://doi.org/10.1007/s00210-023-02755-4" @default.
• W4387530817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37819391" @default.
• W4387530817 hasPublicationYear "2023" @default.
• W4387530817 type Work @default.
• W4387530817 citedByCount "0" @default.
• W4387530817 crossrefType "journal-article" @default.
• W4387530817 hasAuthorship W4387530817A5009224694 @default.
• W4387530817 hasAuthorship W4387530817A5025060135 @default.
• W4387530817 hasAuthorship W4387530817A5037945875 @default.
• W4387530817 hasAuthorship W4387530817A5087863289 @default.
• W4387530817 hasBestOaLocation W43875308171 @default.
• W4387530817 hasConcept C104317684 @default.
• W4387530817 hasConcept C109316439 @default.
• W4387530817 hasConcept C121608353 @default.
• W4387530817 hasConcept C127561419 @default.
• W4387530817 hasConcept C153911025 @default.
• W4387530817 hasConcept C154317977 @default.
• W4387530817 hasConcept C185592680 @default.
• W4387530817 hasConcept C190283241 @default.
• W4387530817 hasConcept C202751555 @default.
• W4387530817 hasConcept C2776344562 @default.
• W4387530817 hasConcept C2777752497 @default.
• W4387530817 hasConcept C2778004101 @default.
• W4387530817 hasConcept C2778362808 @default.
• W4387530817 hasConcept C2780783641 @default.
• W4387530817 hasConcept C29537977 @default.
• W4387530817 hasConcept C54355233 @default.
• W4387530817 hasConcept C553184892 @default.
• W4387530817 hasConcept C55493867 @default.
• W4387530817 hasConcept C86803240 @default.
• W4387530817 hasConcept C88634738 @default.
• W4387530817 hasConcept C96232424 @default.
• W4387530817 hasConceptScore W4387530817C104317684 @default.
• W4387530817 hasConceptScore W4387530817C109316439 @default.
• W4387530817 hasConceptScore W4387530817C121608353 @default.
• W4387530817 hasConceptScore W4387530817C127561419 @default.
• W4387530817 hasConceptScore W4387530817C153911025 @default.
• W4387530817 hasConceptScore W4387530817C154317977 @default.
• W4387530817 hasConceptScore W4387530817C185592680 @default.
• W4387530817 hasConceptScore W4387530817C190283241 @default.
• W4387530817 hasConceptScore W4387530817C202751555 @default.
• W4387530817 hasConceptScore W4387530817C2776344562 @default.
• W4387530817 hasConceptScore W4387530817C2777752497 @default.
• W4387530817 hasConceptScore W4387530817C2778004101 @default.
• W4387530817 hasConceptScore W4387530817C2778362808 @default.
• W4387530817 hasConceptScore W4387530817C2780783641 @default.
• W4387530817 hasConceptScore W4387530817C29537977 @default.
• W4387530817 hasConceptScore W4387530817C54355233 @default.
• W4387530817 hasConceptScore W4387530817C553184892 @default.
• W4387530817 hasConceptScore W4387530817C55493867 @default.
• W4387530817 hasConceptScore W4387530817C86803240 @default.
• W4387530817 hasConceptScore W4387530817C88634738 @default.
• W4387530817 hasConceptScore W4387530817C96232424 @default.
• W4387530817 hasFunder F4320325647 @default.

• next