FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387531208> ?p ?o ?g. }

• W4387531208 abstract "Abstract A majority of cancers, including colorectal cancer (CRC) with intact DNA mismatch repair, exhibit a paralyzed antitumor immune response and resistance to immune checkpoint inhibitors. Members of MHC class III lymphocyte antigen 6G (LY6G) encode glycosylphosphatidylinositol (GPI) proteins anchored to the membrane. Snake venom neurotoxins and LY6G proteins share a three‐finger (3F) folding domain. LY6 proteins such as LY6G6D are gaining a reputation as excellent tumor‐associated antigens that can potently inhibit anti‐tumor immunity in cancers with proficient mismatch repair. Thus, we called MHC class III LY6G endogenous immunotoxins. Since the discovery of LY6G6D as a tumor‐associated antigen, T‐cell engagers (TcEs) have been developed to simultaneously bind LY6G6D on cancer cells and CD3 on T cells, improving the treatment of metastatic solid tumors that are resistant to ICIs. We present a current understanding of how alterations in MHC class III genes inhibit antitumor immunity, and how these understandings can be turned into effective treatments for patients who are refractory to standard immunotherapy. This article is categorized under: Cancer > Genetics/Genomics/Epigenetics Cancer > Molecular and Cellular Physiology" @default.
• W4387531208 created "2023-10-12" @default.
• W4387531208 creator A5014449716 @default.
• W4387531208 creator A5074192479 @default.
• W4387531208 date "2023-10-11" @default.
• W4387531208 modified "2023-10-13" @default.
• W4387531208 title "<scp>MHC</scp> class <scp>III</scp> lymphocyte antigens 6 as endogenous immunotoxins: Unlocking immunotherapy in proficient mismatch repair colorectal cancer" @default.
• W4387531208 cites W1544851750 @default.
• W4387531208 cites W1607246558 @default.
• W4387531208 cites W1988230656 @default.
• W4387531208 cites W2016397546 @default.
• W4387531208 cites W2081374651 @default.
• W4387531208 cites W2100529316 @default.
• W4387531208 cites W2104574946 @default.
• W4387531208 cites W2220679566 @default.
• W4387531208 cites W2622499649 @default.
• W4387531208 cites W2761923993 @default.
• W4387531208 cites W2782669301 @default.
• W4387531208 cites W2900499839 @default.
• W4387531208 cites W2911179399 @default.
• W4387531208 cites W2911407981 @default.
• W4387531208 cites W2914013948 @default.
• W4387531208 cites W2915645504 @default.
• W4387531208 cites W2920863623 @default.
• W4387531208 cites W2921371587 @default.
• W4387531208 cites W2934533555 @default.
• W4387531208 cites W2950512597 @default.
• W4387531208 cites W2963202264 @default.
• W4387531208 cites W3033059513 @default.
• W4387531208 cites W3088633119 @default.
• W4387531208 cites W3113050600 @default.
• W4387531208 cites W3127848815 @default.
• W4387531208 cites W3128947834 @default.
• W4387531208 cites W3134443156 @default.
• W4387531208 cites W3146935595 @default.
• W4387531208 cites W3153990830 @default.
• W4387531208 cites W3178723556 @default.
• W4387531208 cites W3182666770 @default.
• W4387531208 cites W3187644677 @default.
• W4387531208 cites W3200574709 @default.
• W4387531208 cites W3200754639 @default.
• W4387531208 cites W3209660117 @default.
• W4387531208 cites W4223439693 @default.
• W4387531208 cites W4225615384 @default.
• W4387531208 cites W4290973163 @default.
• W4387531208 cites W4296115095 @default.
• W4387531208 cites W4313377101 @default.
• W4387531208 doi "https://doi.org/10.1002/wsbm.1631" @default.
• W4387531208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37818781" @default.
• W4387531208 hasPublicationYear "2023" @default.
• W4387531208 type Work @default.
• W4387531208 citedByCount "0" @default.
• W4387531208 crossrefType "journal-article" @default.
• W4387531208 hasAuthorship W4387531208A5014449716 @default.
• W4387531208 hasAuthorship W4387531208A5074192479 @default.
• W4387531208 hasConcept C115085202 @default.
• W4387531208 hasConcept C121608353 @default.
• W4387531208 hasConcept C147483822 @default.
• W4387531208 hasConcept C159654299 @default.
• W4387531208 hasConcept C170627219 @default.
• W4387531208 hasConcept C203014093 @default.
• W4387531208 hasConcept C207936829 @default.
• W4387531208 hasConcept C2776885095 @default.
• W4387531208 hasConcept C2777701055 @default.
• W4387531208 hasConcept C2780674031 @default.
• W4387531208 hasConcept C502942594 @default.
• W4387531208 hasConcept C542903549 @default.
• W4387531208 hasConcept C54355233 @default.
• W4387531208 hasConcept C86803240 @default.
• W4387531208 hasConcept C8891405 @default.
• W4387531208 hasConceptScore W4387531208C115085202 @default.
• W4387531208 hasConceptScore W4387531208C121608353 @default.
• W4387531208 hasConceptScore W4387531208C147483822 @default.
• W4387531208 hasConceptScore W4387531208C159654299 @default.
• W4387531208 hasConceptScore W4387531208C170627219 @default.
• W4387531208 hasConceptScore W4387531208C203014093 @default.
• W4387531208 hasConceptScore W4387531208C207936829 @default.
• W4387531208 hasConceptScore W4387531208C2776885095 @default.
• W4387531208 hasConceptScore W4387531208C2777701055 @default.
• W4387531208 hasConceptScore W4387531208C2780674031 @default.
• W4387531208 hasConceptScore W4387531208C502942594 @default.
• W4387531208 hasConceptScore W4387531208C542903549 @default.
• W4387531208 hasConceptScore W4387531208C54355233 @default.
• W4387531208 hasConceptScore W4387531208C86803240 @default.
• W4387531208 hasConceptScore W4387531208C8891405 @default.
• W4387531208 hasLocation W43875312081 @default.
• W4387531208 hasLocation W43875312082 @default.
• W4387531208 hasOpenAccess W4387531208 @default.
• W4387531208 hasPrimaryLocation W43875312081 @default.
• W4387531208 hasRelatedWork W1517312530 @default.
• W4387531208 hasRelatedWork W1840653008 @default.
• W4387531208 hasRelatedWork W1992752083 @default.
• W4387531208 hasRelatedWork W2141927426 @default.
• W4387531208 hasRelatedWork W2783288907 @default.
• W4387531208 hasRelatedWork W2977793531 @default.
• W4387531208 hasRelatedWork W3154696046 @default.
• W4387531208 hasRelatedWork W4244021869 @default.
• W4387531208 hasRelatedWork W4289540427 @default.
• W4387531208 hasRelatedWork W4306639591 @default.
• W4387531208 isParatext "false" @default.

• next