Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387532154> ?p ?o ?g. }
- W4387532154 abstract "Abstract Plasma cell disorders are clonal outgrowths of pre-malignant or malignant plasma cells, characterized by extensive chromosomal aberrations. Centrosome abnormalities are a major driver of chromosomal instability in cancer but their origin, incidence, and composition in primary tumor cells is poorly understood. Using cutting-edge, semi-automated high-throughput electron tomography, we characterized at nanoscale 1386 centrioles in CD138 pos plasma cells from eight healthy donors and 21 patients with plasma cell disorders, and 722 centrioles from different control populations. In plasma cells from healthy individuals, over-elongated centrioles accumulated with age. In plasma cell disorders, centriole over-elongation was notably frequent in early, pre-malignant disease stages, became less pronounced in overt multiple myeloma, and almost entirely disappeared in aggressive plasma cell leukemia. Centrioles in other types of patient-derived B cell neoplasms showed no over-elongation. In contrast to current belief, centriole length appears to be highly variable in long-lived, healthy plasma cells, and over-elongation and structural aberrations are common in this cell type. Our data suggest that structural centrosome aberrations accumulate with age in healthy CD138 pos plasma cells and may thus play an important role in early aneuploidization as an oncogenic driver in plasma cell disorders." @default.
- W4387532154 created "2023-10-12" @default.
- W4387532154 creator A5001421636 @default.
- W4387532154 creator A5001651530 @default.
- W4387532154 creator A5019570679 @default.
- W4387532154 creator A5024780153 @default.
- W4387532154 creator A5028388949 @default.
- W4387532154 creator A5035015123 @default.
- W4387532154 creator A5035448242 @default.
- W4387532154 creator A5046953926 @default.
- W4387532154 creator A5047272364 @default.
- W4387532154 creator A5049392355 @default.
- W4387532154 creator A5050574238 @default.
- W4387532154 creator A5052636654 @default.
- W4387532154 creator A5055208985 @default.
- W4387532154 creator A5057528194 @default.
- W4387532154 creator A5070221339 @default.
- W4387532154 creator A5077620734 @default.
- W4387532154 creator A5078452627 @default.
- W4387532154 creator A5084557570 @default.
- W4387532154 creator A5085146093 @default.
- W4387532154 creator A5085434141 @default.
- W4387532154 date "2023-10-11" @default.
- W4387532154 modified "2023-10-18" @default.
- W4387532154 title "High-throughput electron tomography identifies centriole over-elongation as an early event in plasma cell disorders" @default.
- W4387532154 cites W1550723234 @default.
- W4387532154 cites W1912910647 @default.
- W4387532154 cites W1951009334 @default.
- W4387532154 cites W1956871134 @default.
- W4387532154 cites W2005073257 @default.
- W4387532154 cites W2015881641 @default.
- W4387532154 cites W2024687001 @default.
- W4387532154 cites W2065890382 @default.
- W4387532154 cites W2071337242 @default.
- W4387532154 cites W2086990334 @default.
- W4387532154 cites W2090966394 @default.
- W4387532154 cites W2115908058 @default.
- W4387532154 cites W2117401183 @default.
- W4387532154 cites W2117692326 @default.
- W4387532154 cites W2126816979 @default.
- W4387532154 cites W2133920348 @default.
- W4387532154 cites W2134139148 @default.
- W4387532154 cites W2134590240 @default.
- W4387532154 cites W2149858388 @default.
- W4387532154 cites W2189225177 @default.
- W4387532154 cites W2511571730 @default.
- W4387532154 cites W2519134577 @default.
- W4387532154 cites W2582256818 @default.
- W4387532154 cites W2728050420 @default.
- W4387532154 cites W2746999023 @default.
- W4387532154 cites W2762584070 @default.
- W4387532154 cites W2783064655 @default.
- W4387532154 cites W2789611794 @default.
- W4387532154 cites W2794465828 @default.
- W4387532154 cites W2800299398 @default.
- W4387532154 cites W2830196912 @default.
- W4387532154 cites W2843925039 @default.
- W4387532154 cites W2890354249 @default.
- W4387532154 cites W2897064819 @default.
- W4387532154 cites W2905667684 @default.
- W4387532154 cites W2948371032 @default.
- W4387532154 cites W2969709096 @default.
- W4387532154 cites W2978474447 @default.
- W4387532154 cites W2981552021 @default.
- W4387532154 cites W2982291252 @default.
- W4387532154 cites W2996372803 @default.
- W4387532154 cites W3003949123 @default.
- W4387532154 cites W3015285478 @default.
- W4387532154 cites W3020114628 @default.
- W4387532154 cites W3037260227 @default.
- W4387532154 cites W3091186260 @default.
- W4387532154 cites W3093924329 @default.
- W4387532154 cites W3107088376 @default.
- W4387532154 cites W3126787747 @default.
- W4387532154 cites W3160374663 @default.
- W4387532154 cites W3166197245 @default.
- W4387532154 cites W3194049481 @default.
- W4387532154 cites W3195965567 @default.
- W4387532154 cites W3206778834 @default.
- W4387532154 cites W4206424215 @default.
- W4387532154 cites W4307892565 @default.
- W4387532154 cites W4308036525 @default.
- W4387532154 cites W4319941966 @default.
- W4387532154 cites W4381943701 @default.
- W4387532154 cites W783150221 @default.
- W4387532154 doi "https://doi.org/10.1038/s41375-023-02056-y" @default.
- W4387532154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37821581" @default.
- W4387532154 hasPublicationYear "2023" @default.
- W4387532154 type Work @default.
- W4387532154 citedByCount "0" @default.
- W4387532154 crossrefType "journal-article" @default.
- W4387532154 hasAuthorship W4387532154A5001421636 @default.
- W4387532154 hasAuthorship W4387532154A5001651530 @default.
- W4387532154 hasAuthorship W4387532154A5019570679 @default.
- W4387532154 hasAuthorship W4387532154A5024780153 @default.
- W4387532154 hasAuthorship W4387532154A5028388949 @default.
- W4387532154 hasAuthorship W4387532154A5035015123 @default.
- W4387532154 hasAuthorship W4387532154A5035448242 @default.
- W4387532154 hasAuthorship W4387532154A5046953926 @default.
- W4387532154 hasAuthorship W4387532154A5047272364 @default.