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• W4387534611 endingPage "105890" @default.
• W4387534611 startingPage "105890" @default.
• W4387534611 abstract "Parkinson's disease (PD) is associated with peripheral inflammation and abnormal peripheral blood lymphocyte immune responses. Peripheral blood B-lymphocyte subset distributions and whether they are associated with PD are unclear.Sixty-one PD patients and sixty-one one-to-one paired healthy controls (HCs) were enrolled. We used flow cytometry to perform immunophenotyping of peripheral B-lymphocyte, in vitro stimulation and measured serum cytokine. The relationship between variables and PD were assessed.The percentage of naive B cells in blood of PD patients was decreased, whereas the percentages of regulatory B cells (Bregs), plasma blast cells (PBCs), and double-negative (DN) B cells were increased. The absolute counts of B-lymphocyte and naive B cells in blood of PD patients were decreased. Regression analysis revealed that alterations in the absolute counts of B-lymphocyte and the percentage of Bregs and DN B cells were associated with PD. After stimulation, the percentages of Bregs, PBCs, and switched memory (SwM) B cells increased in PD patients. Additionally, increases in GM-CSF-producing B-cell, IFN-γ-producing B-cell, and TNF-α-producing B-cell percentages were noted in PD. Serum levels of a proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF) and soluble CD40 ligand (sCD40L) were elevated in PD and correlated negatively with the UPDRS III score.Abnormal B-lymphocyte immune responses in peripheral blood may contribute to PD development. Alterations in the absolute counts of B-lymphocyte and the percentage of Bregs and DN B cells are associated with PD. Furthermore, APRIL, BAFF, and sCD40L could be potential targets for intervention in PD." @default.
• W4387534611 created "2023-10-12" @default.
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• W4387534611 date "2023-11-01" @default.
• W4387534611 modified "2023-10-17" @default.
• W4387534611 title "Abnormal immune function of B lymphocyte in peripheral blood of Parkinson's disease" @default.
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• W4387534611 doi "https://doi.org/10.1016/j.parkreldis.2023.105890" @default.
• W4387534611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37839276" @default.
• W4387534611 hasPublicationYear "2023" @default.
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