FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387536404> ?p ?o ?g. }

• W4387536404 abstract "ABSTRACT The abnormal expansion of GGGGCC/CCCCGG hexanucleotide repeats (HR) in C9orf72 is associated with familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Structural polymorphisms of HR result in the multifactorial pathomechanism of ALS/FTD. Consequently, many ongoing studies are focused at developing therapies targeting pathogenic HR RNA. One of them involves small molecules blocking the sequestration of important proteins, preventing the formation of toxic nuclear foci. However, rational design of potential therapeutics is hindered by limited number of structural studies of RNA-ligand complexes. We determined the crystal structure of antisense HR RNA in complex with ANP77 ligand and in the free form. HR RNA folds into a triplex structure composed of four RNA chains. ANP77 interacted with two neighboring single-stranded cytosines to form pseudo-canonical base pairs by adopting sandwich-like conformation and adjusting the position of its naphthyridine units to the helical twist of the RNA. In the unliganded structure, the cytosines formed a peculiar triplex i-motif, assembled by trans C•C+ pair and a third cytosine located at the Hoogsteen edge of the C•C+ pair. These results extend our knowledge of the structural polymorphisms of HR and can be used for the rational design of small molecules targeting disease-related RNAs." @default.
• W4387536404 created "2023-10-12" @default.
• W4387536404 creator A5002730173 @default.
• W4387536404 creator A5004710853 @default.
• W4387536404 creator A5006203190 @default.
• W4387536404 creator A5021788512 @default.
• W4387536404 creator A5024868244 @default.
• W4387536404 creator A5076802966 @default.
• W4387536404 creator A5093043944 @default.
• W4387536404 date "2023-10-10" @default.
• W4387536404 modified "2023-10-18" @default.
• W4387536404 title "Antisense RNA C9orf72 Hexanucleotide Repeat Associated With Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Forms A Triplex-Like Structure and Binds Small Synthetic Ligand" @default.
• W4387536404 cites W1487939329 @default.
• W4387536404 cites W1875625635 @default.
• W4387536404 cites W1881326155 @default.
• W4387536404 cites W1967358203 @default.
• W4387536404 cites W1967565706 @default.
• W4387536404 cites W1979982555 @default.
• W4387536404 cites W1980894900 @default.
• W4387536404 cites W1985388058 @default.
• W4387536404 cites W1986919130 @default.
• W4387536404 cites W2007550449 @default.
• W4387536404 cites W2007568107 @default.
• W4387536404 cites W2013131112 @default.
• W4387536404 cites W2026340703 @default.
• W4387536404 cites W2032741347 @default.
• W4387536404 cites W2037722828 @default.
• W4387536404 cites W2041964860 @default.
• W4387536404 cites W2054068057 @default.
• W4387536404 cites W2054542675 @default.
• W4387536404 cites W2057586457 @default.
• W4387536404 cites W2065219073 @default.
• W4387536404 cites W2069171272 @default.
• W4387536404 cites W2074477465 @default.
• W4387536404 cites W2090908102 @default.
• W4387536404 cites W2092876446 @default.
• W4387536404 cites W2098693660 @default.
• W4387536404 cites W2106982820 @default.
• W4387536404 cites W2123168461 @default.
• W4387536404 cites W2125073277 @default.
• W4387536404 cites W2125931517 @default.
• W4387536404 cites W2137039075 @default.
• W4387536404 cites W2141817328 @default.
• W4387536404 cites W2151226445 @default.
• W4387536404 cites W2154657764 @default.
• W4387536404 cites W2154945114 @default.
• W4387536404 cites W2159946246 @default.
• W4387536404 cites W2164449007 @default.
• W4387536404 cites W2165759309 @default.
• W4387536404 cites W2177364510 @default.
• W4387536404 cites W2185411984 @default.
• W4387536404 cites W2286637061 @default.
• W4387536404 cites W2516471491 @default.
• W4387536404 cites W2617594926 @default.
• W4387536404 cites W2767664549 @default.
• W4387536404 cites W2820941669 @default.
• W4387536404 cites W2902982722 @default.
• W4387536404 cites W2977292877 @default.
• W4387536404 cites W3027613757 @default.
• W4387536404 cites W3104564544 @default.
• W4387536404 cites W3192235802 @default.
• W4387536404 cites W3206038875 @default.
• W4387536404 cites W4200163796 @default.
• W4387536404 cites W4211032499 @default.
• W4387536404 cites W4214573824 @default.
• W4387536404 cites W4224566672 @default.
• W4387536404 cites W4290672950 @default.
• W4387536404 doi "https://doi.org/10.1101/2023.10.10.561654" @default.
• W4387536404 hasPublicationYear "2023" @default.
• W4387536404 type Work @default.
• W4387536404 citedByCount "0" @default.
• W4387536404 crossrefType "posted-content" @default.
• W4387536404 hasAuthorship W4387536404A5002730173 @default.
• W4387536404 hasAuthorship W4387536404A5004710853 @default.
• W4387536404 hasAuthorship W4387536404A5006203190 @default.
• W4387536404 hasAuthorship W4387536404A5021788512 @default.
• W4387536404 hasAuthorship W4387536404A5024868244 @default.
• W4387536404 hasAuthorship W4387536404A5076802966 @default.
• W4387536404 hasAuthorship W4387536404A5093043944 @default.
• W4387536404 hasBestOaLocation W43875364041 @default.
• W4387536404 hasConcept C104317684 @default.
• W4387536404 hasConcept C116569031 @default.
• W4387536404 hasConcept C142724271 @default.
• W4387536404 hasConcept C161624437 @default.
• W4387536404 hasConcept C166252455 @default.
• W4387536404 hasConcept C170493617 @default.
• W4387536404 hasConcept C180754005 @default.
• W4387536404 hasConcept C185592680 @default.
• W4387536404 hasConcept C2777898937 @default.
• W4387536404 hasConcept C2778641062 @default.
• W4387536404 hasConcept C2779134260 @default.
• W4387536404 hasConcept C2779483572 @default.
• W4387536404 hasConcept C2780596555 @default.
• W4387536404 hasConcept C54355233 @default.
• W4387536404 hasConcept C67705224 @default.
• W4387536404 hasConcept C71240020 @default.
• W4387536404 hasConcept C71924100 @default.
• W4387536404 hasConcept C86803240 @default.
• W4387536404 hasConceptScore W4387536404C104317684 @default.
• W4387536404 hasConceptScore W4387536404C116569031 @default.

• next