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• W4387540745 abstract "Abstract A virus infection can be initiated with very few or even a single infectious virion, and as such can become extinct, i.e. stochastically fail to take hold or spread significantly. There are many ways that a fully competent infectious virion, having successfully entered a cell, can fail to cause a productive infection, i.e. one that yields infectious virus progeny. Though many stochastic models (SMs) have been developed and used to estimate a virus infection’s establishment probability, these typically neglect infection failure post virus entry. The SM presented herein introduces parameter $$gamma in (0,1]$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mrow> <mml:mi>γ</mml:mi> <mml:mo>∈</mml:mo> <mml:mo>(</mml:mo> <mml:mn>0</mml:mn> <mml:mo>,</mml:mo> <mml:mn>1</mml:mn> <mml:mo>]</mml:mo> </mml:mrow> </mml:math> which corresponds to the probability that a virion’s entry into a cell will result in a productive cell infection. We derive an expression for the likelihood of infection establishment in this new SM, and find that prophylactic therapy with an antiviral reducing $$gamma$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mi>γ</mml:mi> </mml:math> is at least as good or better at decreasing the establishment probability, compared to antivirals reducing the rates of virus production or virus entry into cells, irrespective of the SM parameters. We investigate the difference in the fraction of cells consumed by so-called extinct versus established virus infections, and find that this distinction becomes biologically meaningless as the probability of establishment approaches zero. We explain why the release of virions continuously over an infectious cell’s lifespan, rather than as a single burst at the end of the cell’s lifespan, does not result in an increased risk of infection extinction. We show, instead, that the number of virus released, not the timing of the release, affects infection establishment and associated critical antiviral efficacy." @default.
• W4387540745 created "2023-10-12" @default.
• W4387540745 creator A5005805170 @default.
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• W4387540745 date "2023-10-11" @default.
• W4387540745 modified "2023-10-14" @default.
• W4387540745 title "The effect of random virus failure following cell entry on infection outcome and the success of antiviral therapy" @default.
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• W4387540745 doi "https://doi.org/10.1038/s41598-023-44180-w" @default.
• W4387540745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37821517" @default.
• W4387540745 hasPublicationYear "2023" @default.
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• W4387540745 hasAuthorship W4387540745A5005805170 @default.
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