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• W4387541100 abstract "Abstract The oral formulation design for colon-specific drug delivery brings some therapeutic benefits in the ulcerative colitis treatment. We recently reported the specific delivery of hemoglobin nanoparticles-conjugating 5-aminosalicylic acid (5-ASA- HbNPs) to the inflamed site. In the current study, the in vivo evaluation of 5-ASA from its bio-adhesive nanoparticles shows the greatly long residence time of 5-ASA and complete support of the colon as compared with free 5-ASA due to the suitable mucoadhesive property to traverse the mucus layer and accumulate within the mucosa is a vital process. Furthermore, the UC model mice exhibited notably reduced indexes of disease activity; along with decreased ratios of colon weight/length in the group treated with 5-ASA-HbNPs. This group received a one-thousandth of the standard dosage of 5-ASA amount (50 μg/kg). While, a similar result was observed for a considerable quantity of free 5-ASA (50 mg/kg), confirming the therapeutic efficacy of this formulation in vivo . Furthermore, microscopic images of histological sections of the extracted colons demonstrated that the 5-ASA-HbNPs and 5-ASA groups displayed instances of inflammatory damage within the colon. However, in comparison to the control group, the extent of this damage was relatively moderate, suggesting 5-ASA-HbNPs improved therapeutic efficacy with the lower dosage form." @default.
• W4387541100 created "2023-10-12" @default.
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• W4387541100 date "2023-10-11" @default.
• W4387541100 modified "2023-10-12" @default.
• W4387541100 title "Oral formulation of 5-aminosalicylic acid-Hemoglobin bio-adhesive nanoparticles enhance therapeutic efficiency in Ulcerative Colitis mice: A preclinical evaluation" @default.
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• W4387541100 doi "https://doi.org/10.21203/rs.3.rs-3416624/v1" @default.
• W4387541100 hasPublicationYear "2023" @default.
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