FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387541435> ?p ?o ?g. }

• W4387541435 abstract "Abstract Diabetic ulcer healing is affected by persistent hyperglycemia, and the current treatment methods are extremely limited. We aim to take the advantages of stem cell therapy and try to use periodontal ligament stem cells that have not yet become therapeutic cells to repair diabetic wounds, so as to provide theoretical basis for its application in clinical practice. Methods: The effect of AGEs on the myofibroblast differentiation ability of hPDLSCs was investigated by RT-qPCR and WBto detect the gene and protein expressions of α-SMA and COLIA1. HE staining and Masson staining were used to observe the effect of hPDLSCs on wound healing in STZ-induced diabetic mice, and immunohistochemical staining was used to detect the expression of α-SMA and CD31. Immunofluorescence (IF) was used to detect the expression of CD206 and iNOS in the tissue of wound area.hPDLSCs can spontaneously differentiate into myoblasts during culture. In α-MEM medium, at 25μg/mL AGEs, the expression of COLIA1 in the seventh passage (P7) cells was significantly decreased, and α-SMA was increased (P < 0.05). hPDLSCs hydrogel injection was used to heal the wounds of C57 mice, and it was found that the healing rate of hPDLSCs group was 65.247% on the 7th day of healing while that of the model group was 48.938%. The healing rate of hPDLSCs treatment group was much higher than that of the model group. Conclusion: hPDLSCs can repair the skin wounds of diabetic mice by spontaneously differentiating into myofibroblasts and resisting the damage of AGEs, which is expected to be used in clinical diagnosis and treatment." @default.
• W4387541435 created "2023-10-12" @default.
• W4387541435 creator A5018043906 @default.
• W4387541435 creator A5030650254 @default.
• W4387541435 creator A5040556753 @default.
• W4387541435 creator A5044386909 @default.
• W4387541435 creator A5045601651 @default.
• W4387541435 creator A5046822662 @default.
• W4387541435 creator A5057922659 @default.
• W4387541435 creator A5084277718 @default.
• W4387541435 date "2023-10-11" @default.
• W4387541435 modified "2023-10-17" @default.
• W4387541435 title "Human periodontal ligament stem cells (hPDLSCs) spontaneously differentiated into myofibroblast to repairer diabetic wounds" @default.
• W4387541435 cites W1920403669 @default.
• W4387541435 cites W1964134361 @default.
• W4387541435 cites W1989848407 @default.
• W4387541435 cites W2013537969 @default.
• W4387541435 cites W2016344976 @default.
• W4387541435 cites W2066627745 @default.
• W4387541435 cites W2113759342 @default.
• W4387541435 cites W2116513474 @default.
• W4387541435 cites W2120630386 @default.
• W4387541435 cites W2144224215 @default.
• W4387541435 cites W2153413302 @default.
• W4387541435 cites W2414890559 @default.
• W4387541435 cites W2606184831 @default.
• W4387541435 cites W2793140478 @default.
• W4387541435 cites W2883340199 @default.
• W4387541435 cites W2888161591 @default.
• W4387541435 cites W2903135877 @default.
• W4387541435 cites W2911511905 @default.
• W4387541435 cites W2940201254 @default.
• W4387541435 cites W2956714488 @default.
• W4387541435 cites W2971195449 @default.
• W4387541435 cites W2994543694 @default.
• W4387541435 cites W3009201649 @default.
• W4387541435 cites W3014023943 @default.
• W4387541435 cites W3024085885 @default.
• W4387541435 cites W3041532009 @default.
• W4387541435 cites W3153569053 @default.
• W4387541435 cites W3168701275 @default.
• W4387541435 cites W3200265213 @default.
• W4387541435 cites W4224307827 @default.
• W4387541435 cites W4225757821 @default.
• W4387541435 cites W4284893400 @default.
• W4387541435 cites W4290098783 @default.
• W4387541435 cites W4294549779 @default.
• W4387541435 cites W4295898643 @default.
• W4387541435 cites W4296380271 @default.
• W4387541435 cites W4308506796 @default.
• W4387541435 cites W4319931028 @default.
• W4387541435 doi "https://doi.org/10.21203/rs.3.rs-3416891/v1" @default.
• W4387541435 hasPublicationYear "2023" @default.
• W4387541435 type Work @default.
• W4387541435 citedByCount "0" @default.
• W4387541435 crossrefType "posted-content" @default.
• W4387541435 hasAuthorship W4387541435A5018043906 @default.
• W4387541435 hasAuthorship W4387541435A5030650254 @default.
• W4387541435 hasAuthorship W4387541435A5040556753 @default.
• W4387541435 hasAuthorship W4387541435A5044386909 @default.
• W4387541435 hasAuthorship W4387541435A5045601651 @default.
• W4387541435 hasAuthorship W4387541435A5046822662 @default.
• W4387541435 hasAuthorship W4387541435A5057922659 @default.
• W4387541435 hasAuthorship W4387541435A5084277718 @default.
• W4387541435 hasBestOaLocation W43875414351 @default.
• W4387541435 hasConcept C141071460 @default.
• W4387541435 hasConcept C142724271 @default.
• W4387541435 hasConcept C160160445 @default.
• W4387541435 hasConcept C171056886 @default.
• W4387541435 hasConcept C181199279 @default.
• W4387541435 hasConcept C185592680 @default.
• W4387541435 hasConcept C199343813 @default.
• W4387541435 hasConcept C204232928 @default.
• W4387541435 hasConcept C207865475 @default.
• W4387541435 hasConcept C2779886569 @default.
• W4387541435 hasConcept C2780269544 @default.
• W4387541435 hasConcept C2780559512 @default.
• W4387541435 hasConcept C28328180 @default.
• W4387541435 hasConcept C41868710 @default.
• W4387541435 hasConcept C55493867 @default.
• W4387541435 hasConcept C71924100 @default.
• W4387541435 hasConcept C74864618 @default.
• W4387541435 hasConcept C86803240 @default.
• W4387541435 hasConcept C95444343 @default.
• W4387541435 hasConceptScore W4387541435C141071460 @default.
• W4387541435 hasConceptScore W4387541435C142724271 @default.
• W4387541435 hasConceptScore W4387541435C160160445 @default.
• W4387541435 hasConceptScore W4387541435C171056886 @default.
• W4387541435 hasConceptScore W4387541435C181199279 @default.
• W4387541435 hasConceptScore W4387541435C185592680 @default.
• W4387541435 hasConceptScore W4387541435C199343813 @default.
• W4387541435 hasConceptScore W4387541435C204232928 @default.
• W4387541435 hasConceptScore W4387541435C207865475 @default.
• W4387541435 hasConceptScore W4387541435C2779886569 @default.
• W4387541435 hasConceptScore W4387541435C2780269544 @default.
• W4387541435 hasConceptScore W4387541435C2780559512 @default.
• W4387541435 hasConceptScore W4387541435C28328180 @default.
• W4387541435 hasConceptScore W4387541435C41868710 @default.
• W4387541435 hasConceptScore W4387541435C55493867 @default.
• W4387541435 hasConceptScore W4387541435C71924100 @default.

• next