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• W4387541688 endingPage "147873" @default.
• W4387541688 startingPage "147873" @default.
• W4387541688 abstract "Exosome-mediated epithelial mesenchymal transition (EMT) is key to cancer metastasis. c-Src is involved in the secretion of exosomes and initiation of EMT. Effects of exosomes from metastatic non-small cell lung carcinoma (NSCLC) cells on the EMT process in primary NSCLC cells were assessed. Levels of c-Src in NSCLC tissues were detected and the influence of exosomes from metastatic NSCLC cells on the exosome secretion and EMT process in primary NSCLC cells was assessed. The expression of c-Src was modulated, and the influence on the secretion of exosomes and EMT initiation was evaluated. The level of c-Src was higher in NSCLC specimen and NSCLC cells with promoted EMT process. The suppression of c-Src inhibited secretion of exosomes. Exosomes from metastatic NSCLC cells enhanced migration and invasion abilities of primary NSCLC cells, which had identical effects to c-Src overexpression. The suppression of c-Src inhibited growth and metastasis of solid tumors as well as secretion of exosomes, while the injection of exosomes with c-Src overexpression promoted lung metastasis. TGF-β1 restored the invasion and migration abilities even with c-Src knockdown. The exosomes from metastatic NSCLC cells with high c-Src expression of can increase c-Src level in primary NSCLC cells, contributing to the promoted EMT process through TGF-β1 pathway." @default.
• W4387541688 created "2023-10-12" @default.
• W4387541688 creator A5015599233 @default.
• W4387541688 creator A5037431424 @default.
• W4387541688 date "2024-01-01" @default.
• W4387541688 modified "2023-10-18" @default.
• W4387541688 title "Exosomes secreted by metastatic cancer cells promotes epithelial mesenchymal transition in small cell lung carcinoma: the key role of Src/TGF-β1 axis" @default.
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• W4387541688 doi "https://doi.org/10.1016/j.gene.2023.147873" @default.
• W4387541688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37832808" @default.
• W4387541688 hasPublicationYear "2024" @default.
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