Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387541872> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4387541872 abstract "Post-transplant cyclophosphamide (PTCy) has become standard-of-care for graft-vs-host disease (GVHD) prophylaxis, including allowing expanded donor options. However, there is little literature examining outcomes of patients with reduced systolic function receiving PTCy.This study aims to describe our experience in transplanting patients with reduced systolic function, including their non-relapse related mortality (NRM), overall survival (OS), and cumulative incidence of early cardiac events (ECE).This study is a retrospective descriptive analysis using the Johns Hopkins Hematologic Malignancy database. From 2017 through 2021, 1118 consecutive patients underwent allogeneic transplantation with a non-myeloablative (NMA) conditioning and PTCy. A total of 43 of those patients were found to have a pretransplant left ventricular ejection fraction (LVEF) ≤ 45% measured by transthoracic echocardiography. Patients whose LVEF improved on treatment prior to transplant were also included. These two cohorts were stratified into heart failure with reduced ejection fraction (HFrEF) and heart failure with recovered ejection fraction (HFrecEF), and subgroup analysis compared NRM, OS, and cumulative incidence of ECE. ECE was defined as arrhythmia, coronary artery disease, reduction in LVEF, or pericardial effusion within 100 days post-transplant.The median LVEF for 31 patients undergoing transplant with HFrEF was 40-45% (range 30-45%) and 35-40% (range 20-45%) for the 12 patients with HFrecEF. The NRM for all 43 patients was 16% (5-27%) at 100 days and 23% (11-36%) at 2 years. The NRM was 23% (8-38%) and 26% (10-42%) at 100 days and 2 years for the HFrEF cohort and 0 and 18% (0-41%) at 100 days and 2 years for the HFrecEf cohort. The OS at 3 years was 41% (26-62%), 40% (25-65%) and 38% (14-100%) in combined, HFrEF, and HFrecEF cohorts, respectively. The cumulative incidence of any ECE was 37.2% (22-51.9%), including 39% of HFrEF subjects and 33% of HFrecEF subjects. Grade 3 or higher toxicities were seen in 56% of patients. A reduction in ejection fraction was the most common ECE. One death was attributable to a cardiac etiology.Cardiac toxicities seemed to frequent and severe in patients with a history of systolic dysfunction, but these do not lead to worse survival outcomes. This study adds to and extends existing literature supporting NMA conditioning and PTCy in patients with systolic dysfunction." @default.
- W4387541872 created "2023-10-12" @default.
- W4387541872 creator A5026586699 @default.
- W4387541872 creator A5035049914 @default.
- W4387541872 creator A5036664711 @default.
- W4387541872 creator A5045141303 @default.
- W4387541872 creator A5073980557 @default.
- W4387541872 creator A5082071772 @default.
- W4387541872 date "2023-10-01" @default.
- W4387541872 modified "2023-10-15" @default.
- W4387541872 title "Allogeneic Hematopoietic Cell Transplantation with Non-Myeloablative Conditioning and Post-Transplant Cyclophosphamide Prophylaxis in Patients with Reduced Systolic Function" @default.
- W4387541872 cites W1920742048 @default.
- W4387541872 cites W1983593884 @default.
- W4387541872 cites W1993082468 @default.
- W4387541872 cites W1998794592 @default.
- W4387541872 cites W2020853528 @default.
- W4387541872 cites W2039910421 @default.
- W4387541872 cites W2073140442 @default.
- W4387541872 cites W2091805616 @default.
- W4387541872 cites W2109081248 @default.
- W4387541872 cites W2128812336 @default.
- W4387541872 cites W2140690834 @default.
- W4387541872 cites W2160666689 @default.
- W4387541872 cites W2592493755 @default.
- W4387541872 cites W2731092161 @default.
- W4387541872 cites W2733429355 @default.
- W4387541872 cites W3002014144 @default.
- W4387541872 cites W3161808515 @default.
- W4387541872 cites W3167244443 @default.
- W4387541872 cites W3202988567 @default.
- W4387541872 cites W4381487086 @default.
- W4387541872 doi "https://doi.org/10.1016/j.jtct.2023.10.011" @default.
- W4387541872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37832717" @default.
- W4387541872 hasPublicationYear "2023" @default.
- W4387541872 type Work @default.
- W4387541872 citedByCount "0" @default.
- W4387541872 crossrefType "journal-article" @default.
- W4387541872 hasAuthorship W4387541872A5026586699 @default.
- W4387541872 hasAuthorship W4387541872A5035049914 @default.
- W4387541872 hasAuthorship W4387541872A5036664711 @default.
- W4387541872 hasAuthorship W4387541872A5045141303 @default.
- W4387541872 hasAuthorship W4387541872A5073980557 @default.
- W4387541872 hasAuthorship W4387541872A5082071772 @default.
- W4387541872 hasConcept C111566952 @default.
- W4387541872 hasConcept C126322002 @default.
- W4387541872 hasConcept C141071460 @default.
- W4387541872 hasConcept C164705383 @default.
- W4387541872 hasConcept C167135981 @default.
- W4387541872 hasConcept C2776694085 @default.
- W4387541872 hasConcept C2776755627 @default.
- W4387541872 hasConcept C2778198053 @default.
- W4387541872 hasConcept C2778213512 @default.
- W4387541872 hasConcept C2911091166 @default.
- W4387541872 hasConcept C71924100 @default.
- W4387541872 hasConcept C78085059 @default.
- W4387541872 hasConcept C88879693 @default.
- W4387541872 hasConceptScore W4387541872C111566952 @default.
- W4387541872 hasConceptScore W4387541872C126322002 @default.
- W4387541872 hasConceptScore W4387541872C141071460 @default.
- W4387541872 hasConceptScore W4387541872C164705383 @default.
- W4387541872 hasConceptScore W4387541872C167135981 @default.
- W4387541872 hasConceptScore W4387541872C2776694085 @default.
- W4387541872 hasConceptScore W4387541872C2776755627 @default.
- W4387541872 hasConceptScore W4387541872C2778198053 @default.
- W4387541872 hasConceptScore W4387541872C2778213512 @default.
- W4387541872 hasConceptScore W4387541872C2911091166 @default.
- W4387541872 hasConceptScore W4387541872C71924100 @default.
- W4387541872 hasConceptScore W4387541872C78085059 @default.
- W4387541872 hasConceptScore W4387541872C88879693 @default.
- W4387541872 hasLocation W43875418721 @default.
- W4387541872 hasLocation W43875418722 @default.
- W4387541872 hasOpenAccess W4387541872 @default.
- W4387541872 hasPrimaryLocation W43875418721 @default.
- W4387541872 hasRelatedWork W2011390101 @default.
- W4387541872 hasRelatedWork W2033060138 @default.
- W4387541872 hasRelatedWork W2368917118 @default.
- W4387541872 hasRelatedWork W2376339215 @default.
- W4387541872 hasRelatedWork W2377902034 @default.
- W4387541872 hasRelatedWork W2393990342 @default.
- W4387541872 hasRelatedWork W2605975631 @default.
- W4387541872 hasRelatedWork W3110630109 @default.
- W4387541872 hasRelatedWork W3155674270 @default.
- W4387541872 hasRelatedWork W3187572025 @default.
- W4387541872 isParatext "false" @default.
- W4387541872 isRetracted "false" @default.
- W4387541872 workType "article" @default.