Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387542004> ?p ?o ?g. }
- W4387542004 abstract "Introduction Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease. As a clinical empirical prescription of traditional Chinese medicine, Qushi Huayu decoction (QHD) has attracted considerable attention for its advantages in multi-target treatment of NAFLD. However, the intervention mechanism of QHD on abnormal lipid levels and gut microbiota in NAFLD has not been reported. Methods Therefore, we verified the therapeutic effect of QHD on high-fat diet (HFD)-induced NAFLD in rats by physiological parameters and histopathological examination. In addition, studies on gut microbiota and serum lipidomics based on 16S rRNA sequencing and ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS) were conducted to elucidate the therapeutic mechanism of NAFLD in QHD. Results The changes in gut microbiota in NAFLD rats are mainly reflected in their diversity and composition, while QHD treated rats restored these changes. The genera Blautia, Lactobacillus, Allobaculum, Lachnoclostridium and Bacteroides were predominant in the NAFLD group, whereas, Turicibacter, Blautia, Sporosarcina, Romboutsia, Clostridium_sensu_stricto_1, Allobaculum , and Psychrobacter were predominant in the NAFLD+QHD group. Lipid subclasses, including diacylglycerol (DG), triglycerides (TG), phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidic acid (PA), phosphatidylserine (PS), lysophosphatidylinositol (LPI), and phosphatidylglycerol (PG), were significantly different between the NAFLD and the control groups, while QHD treatment significantly altered the levels of DG, TG, PA, lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), and platelet activating factor (PAF). Finally, Spearman’s correlation analysis showed that NAFLD related differential lipid molecules were mainly associated with the genera of Bacteroides, Blautia, Lachnoclostridium, Clostridium_sensu_stricto_1 , and Turicibacter , which were also significantly correlated with the biological parameters of NAFLD. Discussion Taken together, QHD may exert beneficial effects by regulating the gut microbiota and thus intervening in serum lipids." @default.
- W4387542004 created "2023-10-12" @default.
- W4387542004 creator A5006822602 @default.
- W4387542004 creator A5008420458 @default.
- W4387542004 creator A5018593334 @default.
- W4387542004 creator A5033004974 @default.
- W4387542004 creator A5042157361 @default.
- W4387542004 creator A5043412682 @default.
- W4387542004 creator A5053037150 @default.
- W4387542004 creator A5056007719 @default.
- W4387542004 creator A5057910663 @default.
- W4387542004 date "2023-10-11" @default.
- W4387542004 modified "2023-10-12" @default.
- W4387542004 title "Qushi Huayu decoction ameliorates non-alcoholic fatty liver disease in rats by modulating gut microbiota and serum lipids" @default.
- W4387542004 cites W143852723 @default.
- W4387542004 cites W1932390491 @default.
- W4387542004 cites W1975170354 @default.
- W4387542004 cites W1992204617 @default.
- W4387542004 cites W2002464497 @default.
- W4387542004 cites W2023615726 @default.
- W4387542004 cites W2030191059 @default.
- W4387542004 cites W2083923706 @default.
- W4387542004 cites W2139166152 @default.
- W4387542004 cites W2468692184 @default.
- W4387542004 cites W2522015218 @default.
- W4387542004 cites W2523687917 @default.
- W4387542004 cites W2591393531 @default.
- W4387542004 cites W2600588599 @default.
- W4387542004 cites W2602857366 @default.
- W4387542004 cites W2605431828 @default.
- W4387542004 cites W2607572215 @default.
- W4387542004 cites W2752979852 @default.
- W4387542004 cites W2766972897 @default.
- W4387542004 cites W2770903823 @default.
- W4387542004 cites W2788261792 @default.
- W4387542004 cites W2886506348 @default.
- W4387542004 cites W2891610979 @default.
- W4387542004 cites W2904403202 @default.
- W4387542004 cites W2909554637 @default.
- W4387542004 cites W2913237386 @default.
- W4387542004 cites W2919002166 @default.
- W4387542004 cites W2923941208 @default.
- W4387542004 cites W2947765622 @default.
- W4387542004 cites W2967974740 @default.
- W4387542004 cites W2972533507 @default.
- W4387542004 cites W2989301567 @default.
- W4387542004 cites W2990744049 @default.
- W4387542004 cites W2992827117 @default.
- W4387542004 cites W2999444015 @default.
- W4387542004 cites W3009231580 @default.
- W4387542004 cites W3044264576 @default.
- W4387542004 cites W3082210233 @default.
- W4387542004 cites W3092436159 @default.
- W4387542004 cites W3095058004 @default.
- W4387542004 cites W3104901930 @default.
- W4387542004 cites W3135025095 @default.
- W4387542004 cites W3157937763 @default.
- W4387542004 cites W3159160824 @default.
- W4387542004 cites W3167945921 @default.
- W4387542004 cites W3171221564 @default.
- W4387542004 cites W3197814387 @default.
- W4387542004 cites W3200935965 @default.
- W4387542004 cites W3207551042 @default.
- W4387542004 cites W3217636183 @default.
- W4387542004 cites W4210826444 @default.
- W4387542004 cites W4220941576 @default.
- W4387542004 cites W4281786295 @default.
- W4387542004 cites W4285096983 @default.
- W4387542004 cites W4289843496 @default.
- W4387542004 cites W4297906436 @default.
- W4387542004 cites W4303520628 @default.
- W4387542004 cites W4303644443 @default.
- W4387542004 cites W4308181631 @default.
- W4387542004 cites W4309318599 @default.
- W4387542004 cites W4310355217 @default.
- W4387542004 cites W4315619045 @default.
- W4387542004 cites W4361000000 @default.
- W4387542004 cites W4376224284 @default.
- W4387542004 doi "https://doi.org/10.3389/fendo.2023.1272214" @default.
- W4387542004 hasPublicationYear "2023" @default.
- W4387542004 type Work @default.
- W4387542004 citedByCount "0" @default.
- W4387542004 crossrefType "journal-article" @default.
- W4387542004 hasAuthorship W4387542004A5006822602 @default.
- W4387542004 hasAuthorship W4387542004A5008420458 @default.
- W4387542004 hasAuthorship W4387542004A5018593334 @default.
- W4387542004 hasAuthorship W4387542004A5033004974 @default.
- W4387542004 hasAuthorship W4387542004A5042157361 @default.
- W4387542004 hasAuthorship W4387542004A5043412682 @default.
- W4387542004 hasAuthorship W4387542004A5053037150 @default.
- W4387542004 hasAuthorship W4387542004A5056007719 @default.
- W4387542004 hasAuthorship W4387542004A5057910663 @default.
- W4387542004 hasBestOaLocation W43875420041 @default.
- W4387542004 hasConcept C126322002 @default.
- W4387542004 hasConcept C2778168646 @default.
- W4387542004 hasConcept C2778772119 @default.
- W4387542004 hasConcept C2779134260 @default.
- W4387542004 hasConcept C523546767 @default.
- W4387542004 hasConcept C539455810 @default.
- W4387542004 hasConcept C54355233 @default.