Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387562910> ?p ?o ?g. }
- W4387562910 abstract "Polymeric nanoparticles (NPs) have been extensively designed for theranostic agent delivery. Previous methods for tracking their biological behavior and assessing theranostic efficacy heavily rely on fluorescence or isotope labeling. However, these labeling techniques may alter the physicochemical properties of the labeled NPs, leading to inaccurate biodistribution information. Therefore, it is highly desirable to develop label-free techniques for accurately assessing the biological fate of polymeric NPs. Here, we create discrete oligourethane amphiphiles (DOAs) with methoxy (OMe), hydroxyl (OH), and maleimide (MI) moieties at the dendritic oligo(ethylene glycol) (dOEG) ends. We obtained four types of digital nanorods (NRs) with distinct surface functional groups through self-assembly of a single DOA (OMe and OH NRs) or coassembly of two DOAs (OMe-MI and OH-MI NRs). These unique NRs can be directly quantified in a label-free manner by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Specifically, OMe-MI NRs exhibited the best blood circulation, and OH-MI showed the highest area under the curve (AUC) value after intravenous injection. Biodistribution studies demonstrated that MI-containing NRs generally had lower accumulation in the liver and spleen compared to that of MI-free NRs, except for the comparison between OMe and OMe-MI NRs in the liver. Proteomics studies unveiled the formation of distinct protein coronas that may greatly affect the biological behavior of NRs. This study not only provides a label-free technique for quantifying the pharmacokinetics and biodistribution of polymeric NRs but also highlights the significant impact of surface functional groups on the biological fate of polymeric NPs." @default.
- W4387562910 created "2023-10-13" @default.
- W4387562910 creator A5001143276 @default.
- W4387562910 creator A5008817840 @default.
- W4387562910 creator A5010755344 @default.
- W4387562910 creator A5018940391 @default.
- W4387562910 creator A5024907595 @default.
- W4387562910 creator A5026684550 @default.
- W4387562910 creator A5035785809 @default.
- W4387562910 creator A5036900255 @default.
- W4387562910 creator A5043839950 @default.
- W4387562910 creator A5077362611 @default.
- W4387562910 date "2023-10-12" @default.
- W4387562910 modified "2023-10-18" @default.
- W4387562910 title "Label-Free Quantification of Digital Nanorods Assembled from Discrete Oligourethane Amphiphiles" @default.
- W4387562910 cites W1592617873 @default.
- W4387562910 cites W1971357026 @default.
- W4387562910 cites W1990232537 @default.
- W4387562910 cites W1991856124 @default.
- W4387562910 cites W2015556811 @default.
- W4387562910 cites W2017742898 @default.
- W4387562910 cites W2031103860 @default.
- W4387562910 cites W2035776098 @default.
- W4387562910 cites W2036564362 @default.
- W4387562910 cites W2071030419 @default.
- W4387562910 cites W2071636590 @default.
- W4387562910 cites W2095874369 @default.
- W4387562910 cites W2101312385 @default.
- W4387562910 cites W2109420570 @default.
- W4387562910 cites W2112078820 @default.
- W4387562910 cites W2117981139 @default.
- W4387562910 cites W2130522328 @default.
- W4387562910 cites W2141540858 @default.
- W4387562910 cites W2145530039 @default.
- W4387562910 cites W2156750162 @default.
- W4387562910 cites W2157485847 @default.
- W4387562910 cites W2158151243 @default.
- W4387562910 cites W2158558808 @default.
- W4387562910 cites W2164841185 @default.
- W4387562910 cites W2237082602 @default.
- W4387562910 cites W2302062200 @default.
- W4387562910 cites W2315185034 @default.
- W4387562910 cites W2332299887 @default.
- W4387562910 cites W2344644350 @default.
- W4387562910 cites W2432468663 @default.
- W4387562910 cites W2502132927 @default.
- W4387562910 cites W2515394036 @default.
- W4387562910 cites W2554773181 @default.
- W4387562910 cites W2567629692 @default.
- W4387562910 cites W2613352698 @default.
- W4387562910 cites W2768777252 @default.
- W4387562910 cites W2790261529 @default.
- W4387562910 cites W2801600408 @default.
- W4387562910 cites W2808895931 @default.
- W4387562910 cites W2811501377 @default.
- W4387562910 cites W2883860383 @default.
- W4387562910 cites W2897696420 @default.
- W4387562910 cites W2907782134 @default.
- W4387562910 cites W2968362108 @default.
- W4387562910 cites W2973037624 @default.
- W4387562910 cites W2998882776 @default.
- W4387562910 cites W3003300693 @default.
- W4387562910 cites W3018421538 @default.
- W4387562910 cites W3040816756 @default.
- W4387562910 cites W3049495358 @default.
- W4387562910 cites W3083563945 @default.
- W4387562910 cites W3087308760 @default.
- W4387562910 cites W3093700633 @default.
- W4387562910 cites W3109746568 @default.
- W4387562910 cites W3171481286 @default.
- W4387562910 cites W3174397890 @default.
- W4387562910 cites W3198884354 @default.
- W4387562910 cites W4200110101 @default.
- W4387562910 cites W4200493182 @default.
- W4387562910 cites W4200561001 @default.
- W4387562910 cites W4205824800 @default.
- W4387562910 cites W4210332914 @default.
- W4387562910 cites W4285234183 @default.
- W4387562910 cites W4308181627 @default.
- W4387562910 cites W4309666521 @default.
- W4387562910 cites W4320709457 @default.
- W4387562910 cites W4323363351 @default.
- W4387562910 cites W4385450700 @default.
- W4387562910 doi "https://doi.org/10.1021/jacs.3c07577" @default.
- W4387562910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37822292" @default.
- W4387562910 hasPublicationYear "2023" @default.
- W4387562910 type Work @default.
- W4387562910 citedByCount "0" @default.
- W4387562910 crossrefType "journal-article" @default.
- W4387562910 hasAuthorship W4387562910A5001143276 @default.
- W4387562910 hasAuthorship W4387562910A5008817840 @default.
- W4387562910 hasAuthorship W4387562910A5010755344 @default.
- W4387562910 hasAuthorship W4387562910A5018940391 @default.
- W4387562910 hasAuthorship W4387562910A5024907595 @default.
- W4387562910 hasAuthorship W4387562910A5026684550 @default.
- W4387562910 hasAuthorship W4387562910A5035785809 @default.
- W4387562910 hasAuthorship W4387562910A5036900255 @default.
- W4387562910 hasAuthorship W4387562910A5043839950 @default.
- W4387562910 hasAuthorship W4387562910A5077362611 @default.
- W4387562910 hasConcept C112613896 @default.