Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387562920> ?p ?o ?g. }
- W4387562920 abstract "Ageing is characterised at the molecular level by six transcriptional 'hallmarks of ageing', that are commonly described as progressively affected as time passes. By contrast, the 'Smurf' assay separates high-and-constant-mortality risk individuals from healthy, zero-mortality risk individuals, based on increased intestinal permeability. Performing whole body total RNA sequencing, we found that Smurfness distinguishes transcriptional changes associated with chronological age from those associated with biological age. We show that transcriptional heterogeneity increases with chronological age in non-Smurf individuals preceding the other five hallmarks of ageing that are specifically associated with the Smurf state. Using this approach, we also devise targeted pro-longevity genetic interventions delaying entry in the Smurf state. We anticipate that increased attention to the evolutionary conserved Smurf phenotype will bring about significant advances in our understanding of the mechanisms of ageing." @default.
- W4387562920 created "2023-10-13" @default.
- W4387562920 creator A5003267360 @default.
- W4387562920 creator A5017673808 @default.
- W4387562920 creator A5033395626 @default.
- W4387562920 creator A5041164066 @default.
- W4387562920 creator A5044385664 @default.
- W4387562920 creator A5049408707 @default.
- W4387562920 creator A5056771768 @default.
- W4387562920 creator A5063196127 @default.
- W4387562920 creator A5067562053 @default.
- W4387562920 creator A5068911074 @default.
- W4387562920 creator A5070956204 @default.
- W4387562920 creator A5075506145 @default.
- W4387562920 creator A5089277246 @default.
- W4387562920 creator A5090572918 @default.
- W4387562920 date "2023-10-12" @default.
- W4387562920 modified "2023-10-18" @default.
- W4387562920 title "Smurfness‐based two‐phase model of ageing helps deconvolve the ageing transcriptional signature" @default.
- W4387562920 cites W1488124756 @default.
- W4387562920 cites W1551732699 @default.
- W4387562920 cites W1930889025 @default.
- W4387562920 cites W1967181393 @default.
- W4387562920 cites W1968219928 @default.
- W4387562920 cites W1973240345 @default.
- W4387562920 cites W1974047233 @default.
- W4387562920 cites W1977896930 @default.
- W4387562920 cites W1989930174 @default.
- W4387562920 cites W1994302475 @default.
- W4387562920 cites W1994595131 @default.
- W4387562920 cites W2012178564 @default.
- W4387562920 cites W2014440105 @default.
- W4387562920 cites W2036618981 @default.
- W4387562920 cites W2038963685 @default.
- W4387562920 cites W2047683380 @default.
- W4387562920 cites W2049009766 @default.
- W4387562920 cites W2056124784 @default.
- W4387562920 cites W2056558785 @default.
- W4387562920 cites W2067432938 @default.
- W4387562920 cites W2073768640 @default.
- W4387562920 cites W2080346572 @default.
- W4387562920 cites W2080644309 @default.
- W4387562920 cites W2086164759 @default.
- W4387562920 cites W2089411743 @default.
- W4387562920 cites W2100831836 @default.
- W4387562920 cites W2103017472 @default.
- W4387562920 cites W2103882919 @default.
- W4387562920 cites W2108700752 @default.
- W4387562920 cites W2114104545 @default.
- W4387562920 cites W2117925179 @default.
- W4387562920 cites W2121091193 @default.
- W4387562920 cites W2122043646 @default.
- W4387562920 cites W2126525177 @default.
- W4387562920 cites W2130410032 @default.
- W4387562920 cites W2130906350 @default.
- W4387562920 cites W2137590150 @default.
- W4387562920 cites W2138207763 @default.
- W4387562920 cites W2141224543 @default.
- W4387562920 cites W2146725851 @default.
- W4387562920 cites W2162670203 @default.
- W4387562920 cites W2165404921 @default.
- W4387562920 cites W2179438025 @default.
- W4387562920 cites W2181972589 @default.
- W4387562920 cites W2184719027 @default.
- W4387562920 cites W2295666791 @default.
- W4387562920 cites W2321856601 @default.
- W4387562920 cites W2326644719 @default.
- W4387562920 cites W2577141559 @default.
- W4387562920 cites W2602673171 @default.
- W4387562920 cites W2681714653 @default.
- W4387562920 cites W2758815122 @default.
- W4387562920 cites W2767517408 @default.
- W4387562920 cites W2793267387 @default.
- W4387562920 cites W2796559433 @default.
- W4387562920 cites W2903852841 @default.
- W4387562920 cites W2917207851 @default.
- W4387562920 cites W2935955190 @default.
- W4387562920 cites W2949084038 @default.
- W4387562920 cites W2950221693 @default.
- W4387562920 cites W2952549043 @default.
- W4387562920 cites W2952626583 @default.
- W4387562920 cites W2955742649 @default.
- W4387562920 cites W2955979055 @default.
- W4387562920 cites W2959265559 @default.
- W4387562920 cites W2963149346 @default.
- W4387562920 cites W2964849163 @default.
- W4387562920 cites W2967306255 @default.
- W4387562920 cites W2982137871 @default.
- W4387562920 cites W2982414522 @default.
- W4387562920 cites W3003227212 @default.
- W4387562920 cites W3010435021 @default.
- W4387562920 cites W3015587563 @default.
- W4387562920 cites W3036902097 @default.
- W4387562920 cites W3096294596 @default.
- W4387562920 cites W3105750359 @default.
- W4387562920 cites W3107527779 @default.
- W4387562920 cites W3127922419 @default.
- W4387562920 cites W3133928772 @default.
- W4387562920 cites W3134516572 @default.
- W4387562920 cites W3177774907 @default.