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- W4387563150 abstract "In patients with appendiceal mucinous neoplasm with peritoneal dissemination, a cytoreductive surgery (CRS) with perioperative chemotherapy may result in long-term survival. Disease progression may require secondary cytoreductive surgery (SCRS) and other treatments in selected patients to improve survival and preserve an optimal quality of life.The clinical- and treatment-related variables associated with the index CRS and SCRS were statistically assessed for impact on survival after SCRS.A total of 186 of 687 complete CRS patients (27.1%) had SCRS. Median follow-up was 10 years and median survival was 12 years. In 95 males (51%) the median age was 45.0 years. Survival benefit with SCRS was observed if early postoperative intraperitoneal chemotherapy (EPIC) with 5-fluorouracil (EPIC 5-FU) or hyperthermic intraperitoneal chemotherapy (HIPEC) plus EPIC 5-FU was used with the index CRS (hazard ratio [HR]: 0.6, p = 0.0360; HR: 0.4, p = 0.0004, respectively). By propensity matching of 51 pairs of patients, EPIC 5-FU used with index CRS caused a survival advantage compared to HIPEC alone (p = 0.0100) with index CRS (p = 0.0100).Use of EPIC 5-FU at a complete index CRS was a prognostic variable that improved survival in patients requiring SCRS. Further investigations into the benefits of antiadhesion treatments with CRS and HIPEC are warranted." @default.
- W4387563150 created "2023-10-13" @default.
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- W4387563150 date "2023-10-12" @default.
- W4387563150 modified "2023-10-13" @default.
- W4387563150 title "Use of early postoperative intraperitoneal 5‐fluorouracil with index cytoreduction improves survival with secondary cytoreductive surgery" @default.
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- W4387563150 doi "https://doi.org/10.1002/jso.27464" @default.
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