Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387563225> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4387563225 abstract "Stochastic interventional vaccine efficacy (SVE) analysis is a new approach to correlate of protection (CoP) analysis of a phase 3 trial that estimates how VE would change under hypothetical shifts of an immune marker.We applied nonparametric SVE methodology to the COVE trial of mRNA-1273 vs. placebo to evaluate post-dose 2 pseudovirus neutralizing antibody (nAb) titer against the D614G strain as a CoP against COVID-19. Secondly, we evaluated the ability of these results to predict VE against variants based on shifts of geometric mean titers to variants vs. D614G. Prediction accuracy was evaluated by 13 validation studies, including 12 test-negative designs.SVE analysis of COVE supported post-dose 2 D614G titer as a CoP: estimated VE ranged from 66.9% (95% confidence interval: 36.2, 82.8%) to 99.3% (99.1, 99.4%) at 10-fold decreased or increased titer shifts, respectively. The SVE estimates only weakly predicted variant-specific VE estimates (concordance correlation coefficient 0.062 for post 2-dose VE).SVE analysis of COVE supports nAb titer as a CoP for mRNA vaccines. Predicting variant-specific VE proved difficult due to many limitations. Greater anti-Omicron titers may be needed for high-level protection against Omicron vs. anti-D614G titers needed for high-level protection against pre-Omicron COVID-19." @default.
- W4387563225 created "2023-10-13" @default.
- W4387563225 creator A5000157109 @default.
- W4387563225 creator A5000243107 @default.
- W4387563225 creator A5004036928 @default.
- W4387563225 creator A5019357485 @default.
- W4387563225 creator A5025421448 @default.
- W4387563225 creator A5050864343 @default.
- W4387563225 creator A5052768263 @default.
- W4387563225 creator A5056611428 @default.
- W4387563225 creator A5064664004 @default.
- W4387563225 creator A5074787043 @default.
- W4387563225 creator A5085731242 @default.
- W4387563225 creator A5085762412 @default.
- W4387563225 creator A5091029647 @default.
- W4387563225 date "2023-10-09" @default.
- W4387563225 modified "2023-10-13" @default.
- W4387563225 title "Stochastic Interventional Approach to Assessing Immune Correlates of Protection: Application to the COVE mRNA-1273 Vaccine Trial." @default.
- W4387563225 doi "https://doi.org/10.1016/j.ijid.2023.09.012" @default.
- W4387563225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37820782" @default.
- W4387563225 hasPublicationYear "2023" @default.
- W4387563225 type Work @default.
- W4387563225 citedByCount "0" @default.
- W4387563225 crossrefType "journal-article" @default.
- W4387563225 hasAuthorship W4387563225A5000157109 @default.
- W4387563225 hasAuthorship W4387563225A5000243107 @default.
- W4387563225 hasAuthorship W4387563225A5004036928 @default.
- W4387563225 hasAuthorship W4387563225A5019357485 @default.
- W4387563225 hasAuthorship W4387563225A5025421448 @default.
- W4387563225 hasAuthorship W4387563225A5050864343 @default.
- W4387563225 hasAuthorship W4387563225A5052768263 @default.
- W4387563225 hasAuthorship W4387563225A5056611428 @default.
- W4387563225 hasAuthorship W4387563225A5064664004 @default.
- W4387563225 hasAuthorship W4387563225A5074787043 @default.
- W4387563225 hasAuthorship W4387563225A5085731242 @default.
- W4387563225 hasAuthorship W4387563225A5085762412 @default.
- W4387563225 hasAuthorship W4387563225A5091029647 @default.
- W4387563225 hasConcept C126322002 @default.
- W4387563225 hasConcept C142724271 @default.
- W4387563225 hasConcept C159047783 @default.
- W4387563225 hasConcept C159654299 @default.
- W4387563225 hasConcept C203014093 @default.
- W4387563225 hasConcept C204787440 @default.
- W4387563225 hasConcept C22889606 @default.
- W4387563225 hasConcept C27081682 @default.
- W4387563225 hasConcept C2777451964 @default.
- W4387563225 hasConcept C32611913 @default.
- W4387563225 hasConcept C44249647 @default.
- W4387563225 hasConcept C71924100 @default.
- W4387563225 hasConceptScore W4387563225C126322002 @default.
- W4387563225 hasConceptScore W4387563225C142724271 @default.
- W4387563225 hasConceptScore W4387563225C159047783 @default.
- W4387563225 hasConceptScore W4387563225C159654299 @default.
- W4387563225 hasConceptScore W4387563225C203014093 @default.
- W4387563225 hasConceptScore W4387563225C204787440 @default.
- W4387563225 hasConceptScore W4387563225C22889606 @default.
- W4387563225 hasConceptScore W4387563225C27081682 @default.
- W4387563225 hasConceptScore W4387563225C2777451964 @default.
- W4387563225 hasConceptScore W4387563225C32611913 @default.
- W4387563225 hasConceptScore W4387563225C44249647 @default.
- W4387563225 hasConceptScore W4387563225C71924100 @default.
- W4387563225 hasLocation W43875632251 @default.
- W4387563225 hasOpenAccess W4387563225 @default.
- W4387563225 hasPrimaryLocation W43875632251 @default.
- W4387563225 hasRelatedWork W2038865602 @default.
- W4387563225 hasRelatedWork W2052465442 @default.
- W4387563225 hasRelatedWork W2118520178 @default.
- W4387563225 hasRelatedWork W2271934434 @default.
- W4387563225 hasRelatedWork W2381991529 @default.
- W4387563225 hasRelatedWork W2384171498 @default.
- W4387563225 hasRelatedWork W2411416451 @default.
- W4387563225 hasRelatedWork W4200167841 @default.
- W4387563225 hasRelatedWork W4313375248 @default.
- W4387563225 hasRelatedWork W4366772733 @default.
- W4387563225 isParatext "false" @default.
- W4387563225 isRetracted "false" @default.
- W4387563225 workType "article" @default.