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- W4387563334 abstract "The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by postponement of disease, preservation of function, and increased stress resistance. Whether CR elicits the same physiological and molecular responses in humans remains mostly unexplored. In the CALERIE study, 12% CR for 2 years in healthy humans induced minor losses of muscle mass (leg lean mass) without changes of muscle strength, but mechanisms for muscle quality preservation remained unclear. We performed high-depth RNA-Seq (387-618 million paired reads) on human vastus lateralis muscle biopsies collected from the CALERIE participants at baseline, 12- and 24-month follow-up from the 90 CALERIE participants randomized to CR and ad libitum control. Using linear mixed effect model, we identified protein-coding genes and splicing variants whose expression was significantly changed in the CR group compared to controls, including genes related to proteostasis, circadian rhythm regulation, DNA repair, mitochondrial biogenesis, mRNA processing/splicing, FOXO3 metabolism, apoptosis, and inflammation. Changes in some of these biological pathways mediated part of the positive effect of CR on muscle quality. Differentially expressed splicing variants were associated with change in pathways shown to be affected by CR in model organisms. Two years of sustained CR in humans positively affected skeletal muscle quality, and impacted gene expression and splicing profiles of biological pathways affected by CR in model organisms, suggesting that attainable levels of CR in a lifestyle intervention can benefit muscle health in humans." @default.
- W4387563334 created "2023-10-13" @default.
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- W4387563334 date "2023-10-12" @default.
- W4387563334 modified "2023-10-18" @default.
- W4387563334 title "Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The <scp>CALERIE</scp> study" @default.
- W4387563334 cites W1001450265 @default.
- W4387563334 cites W1033197108 @default.
- W4387563334 cites W1754854497 @default.
- W4387563334 cites W1951724000 @default.
- W4387563334 cites W1975439264 @default.
- W4387563334 cites W1982574573 @default.
- W4387563334 cites W1987589261 @default.
- W4387563334 cites W1989635548 @default.
- W4387563334 cites W1993397999 @default.
- W4387563334 cites W1995381409 @default.
- W4387563334 cites W2004968462 @default.
- W4387563334 cites W2005501973 @default.
- W4387563334 cites W2006772779 @default.
- W4387563334 cites W2010699620 @default.
- W4387563334 cites W2013873946 @default.
- W4387563334 cites W2015743729 @default.
- W4387563334 cites W2016589608 @default.
- W4387563334 cites W2021512852 @default.
- W4387563334 cites W2022190569 @default.
- W4387563334 cites W2023438723 @default.
- W4387563334 cites W2024781917 @default.
- W4387563334 cites W2025192214 @default.
- W4387563334 cites W2027016451 @default.
- W4387563334 cites W2030509917 @default.
- W4387563334 cites W2035289883 @default.
- W4387563334 cites W2037844862 @default.
- W4387563334 cites W2046989794 @default.
- W4387563334 cites W2048046939 @default.
- W4387563334 cites W2050696656 @default.
- W4387563334 cites W2051011478 @default.
- W4387563334 cites W2051658606 @default.
- W4387563334 cites W2052543720 @default.
- W4387563334 cites W2058512647 @default.
- W4387563334 cites W2060792177 @default.
- W4387563334 cites W2062527379 @default.
- W4387563334 cites W2065552408 @default.
- W4387563334 cites W2067279987 @default.
- W4387563334 cites W2070083583 @default.
- W4387563334 cites W2074347699 @default.
- W4387563334 cites W2076435302 @default.
- W4387563334 cites W2078773383 @default.
- W4387563334 cites W2082793902 @default.
- W4387563334 cites W2082852887 @default.
- W4387563334 cites W2083556426 @default.
- W4387563334 cites W2085048595 @default.
- W4387563334 cites W2090684910 @default.
- W4387563334 cites W2091250038 @default.
- W4387563334 cites W2099547258 @default.
- W4387563334 cites W2103416697 @default.
- W4387563334 cites W2103914828 @default.
- W4387563334 cites W2110703071 @default.
- W4387563334 cites W2111617381 @default.
- W4387563334 cites W2112444005 @default.
- W4387563334 cites W2113432343 @default.
- W4387563334 cites W2114104545 @default.
- W4387563334 cites W2123105653 @default.
- W4387563334 cites W2128681277 @default.
- W4387563334 cites W2129490836 @default.
- W4387563334 cites W2130296687 @default.
- W4387563334 cites W2130410032 @default.
- W4387563334 cites W2133918896 @default.
- W4387563334 cites W2136340969 @default.
- W4387563334 cites W2137586531 @default.
- W4387563334 cites W2138207763 @default.
- W4387563334 cites W2140913717 @default.
- W4387563334 cites W2152148024 @default.
- W4387563334 cites W2158124286 @default.
- W4387563334 cites W2161081876 @default.
- W4387563334 cites W2162143298 @default.
- W4387563334 cites W2168027209 @default.
- W4387563334 cites W2169299320 @default.
- W4387563334 cites W2169456326 @default.
- W4387563334 cites W2169617007 @default.
- W4387563334 cites W2172818274 @default.
- W4387563334 cites W2175005753 @default.
- W4387563334 cites W2189652645 @default.
- W4387563334 cites W2195648176 @default.