FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387563464> ?p ?o ?g. }

• W4387563464 endingPage "416" @default.
• W4387563464 startingPage "411" @default.
• W4387563464 abstract "The majority of human tumors are characterized by abnormal signaling caused by oncogenic RAS proteins. KRAS is a member of the RAS family and is currently one of the most thoroughly researched targets for cancer treatment due to its prevalence in a variety of deadly malignancies. Targeting the KRAS protein, which plays a crucial role in regulating cell growth, differentiation, and apoptosis, shows great potential as a strategy for fighting cancer. Herein, in silico screening of 530 natural compounds against KRAS protein was performed. The top-scoring hits, namely ZINC32502206, ZINC98363763, ZINC85645815, and ZINC98364259 displayed a robust affinity towards KRAS as evidenced by their respective binding affinity values of -10.50, -10.01, -9.80, and -9.70 kcal/mol, respectively which were notably higher than that of the control compound AMG 510 (-9.10 kcal/mol). Through virtual screening and visual inspection, it was observed that these hits effectively interacted with the essential residues located within the active site of KRAS. Based on the findings of this study, it can be inferred that these compounds may have the potential to be employed in the treatment of cancer by targeting KRAS." @default.
• W4387563464 created "2023-10-13" @default.
• W4387563464 creator A5003878678 @default.
• W4387563464 creator A5013827619 @default.
• W4387563464 creator A5025038048 @default.
• W4387563464 creator A5030074131 @default.
• W4387563464 creator A5049534252 @default.
• W4387563464 creator A5053341636 @default.
• W4387563464 creator A5093048628 @default.
• W4387563464 creator A5093048629 @default.
• W4387563464 creator A5093048630 @default.
• W4387563464 date "2023-01-01" @default.
• W4387563464 modified "2023-10-14" @default.
• W4387563464 title "Molecular docking analysis of KRAS inhibitors for cancer management." @default.
• W4387563464 cites W1887624773 @default.
• W4387563464 cites W2043282329 @default.
• W4387563464 cites W2058142370 @default.
• W4387563464 cites W2088293068 @default.
• W4387563464 cites W2103237643 @default.
• W4387563464 cites W2233032895 @default.
• W4387563464 cites W2333950962 @default.
• W4387563464 cites W2554099577 @default.
• W4387563464 cites W2953888513 @default.
• W4387563464 cites W2982321167 @default.
• W4387563464 cites W3003697872 @default.
• W4387563464 cites W3013377779 @default.
• W4387563464 cites W3023126697 @default.
• W4387563464 cites W3096658408 @default.
• W4387563464 cites W3128646645 @default.
• W4387563464 cites W3196637241 @default.
• W4387563464 cites W4280586159 @default.
• W4387563464 cites W4310709716 @default.
• W4387563464 doi "https://doi.org/10.6026/97320630019411" @default.
• W4387563464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37822837" @default.
• W4387563464 hasPublicationYear "2023" @default.
• W4387563464 type Work @default.
• W4387563464 citedByCount "0" @default.
• W4387563464 crossrefType "journal-article" @default.
• W4387563464 hasAuthorship W4387563464A5003878678 @default.
• W4387563464 hasAuthorship W4387563464A5013827619 @default.
• W4387563464 hasAuthorship W4387563464A5025038048 @default.
• W4387563464 hasAuthorship W4387563464A5030074131 @default.
• W4387563464 hasAuthorship W4387563464A5049534252 @default.
• W4387563464 hasAuthorship W4387563464A5053341636 @default.
• W4387563464 hasAuthorship W4387563464A5093048628 @default.
• W4387563464 hasAuthorship W4387563464A5093048629 @default.
• W4387563464 hasAuthorship W4387563464A5093048630 @default.
• W4387563464 hasConcept C103697762 @default.
• W4387563464 hasConcept C104317684 @default.
• W4387563464 hasConcept C121608353 @default.
• W4387563464 hasConcept C159110408 @default.
• W4387563464 hasConcept C185592680 @default.
• W4387563464 hasConcept C190283241 @default.
• W4387563464 hasConcept C2775905019 @default.
• W4387563464 hasConcept C2781187634 @default.
• W4387563464 hasConcept C41685203 @default.
• W4387563464 hasConcept C502942594 @default.
• W4387563464 hasConcept C526805850 @default.
• W4387563464 hasConcept C54355233 @default.
• W4387563464 hasConcept C55493867 @default.
• W4387563464 hasConcept C56173144 @default.
• W4387563464 hasConcept C60644358 @default.
• W4387563464 hasConcept C70721500 @default.
• W4387563464 hasConcept C71924100 @default.
• W4387563464 hasConcept C86803240 @default.
• W4387563464 hasConcept C96232424 @default.
• W4387563464 hasConceptScore W4387563464C103697762 @default.
• W4387563464 hasConceptScore W4387563464C104317684 @default.
• W4387563464 hasConceptScore W4387563464C121608353 @default.
• W4387563464 hasConceptScore W4387563464C159110408 @default.
• W4387563464 hasConceptScore W4387563464C185592680 @default.
• W4387563464 hasConceptScore W4387563464C190283241 @default.
• W4387563464 hasConceptScore W4387563464C2775905019 @default.
• W4387563464 hasConceptScore W4387563464C2781187634 @default.
• W4387563464 hasConceptScore W4387563464C41685203 @default.
• W4387563464 hasConceptScore W4387563464C502942594 @default.
• W4387563464 hasConceptScore W4387563464C526805850 @default.
• W4387563464 hasConceptScore W4387563464C54355233 @default.
• W4387563464 hasConceptScore W4387563464C55493867 @default.
• W4387563464 hasConceptScore W4387563464C56173144 @default.
• W4387563464 hasConceptScore W4387563464C60644358 @default.
• W4387563464 hasConceptScore W4387563464C70721500 @default.
• W4387563464 hasConceptScore W4387563464C71924100 @default.
• W4387563464 hasConceptScore W4387563464C86803240 @default.
• W4387563464 hasConceptScore W4387563464C96232424 @default.
• W4387563464 hasIssue "4" @default.
• W4387563464 hasLocation W43875634641 @default.
• W4387563464 hasOpenAccess W4387563464 @default.
• W4387563464 hasPrimaryLocation W43875634641 @default.
• W4387563464 hasRelatedWork W2017055503 @default.
• W4387563464 hasRelatedWork W2027065525 @default.
• W4387563464 hasRelatedWork W2269591907 @default.
• W4387563464 hasRelatedWork W2336040088 @default.
• W4387563464 hasRelatedWork W2773493604 @default.
• W4387563464 hasRelatedWork W2921092150 @default.
• W4387563464 hasRelatedWork W3030972949 @default.
• W4387563464 hasRelatedWork W3174709249 @default.
• W4387563464 hasRelatedWork W4229832877 @default.

• next