FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387563521> ?p ?o ?g. }

• W4387563521 abstract "Rod and cone photoreceptors in the retina of vertebrates are the primary sensory neurons underlying vision. They convert light into an electrical current using a signal transduction pathway that depends on Ca[Formula: see text] feedback. It is known that manipulating the Ca[Formula: see text] kinetics affects the response shape and the photoreceptor sensitivity, but a precise quantification of these effects remains unclear. We have approached this task in mouse retina by combining numerical simulations with mathematical analysis. We consider a parsimonious phototransduction model that incorporates negative Ca[Formula: see text] feedback onto the synthesis of cyclic GMP, and fast buffering reactions to alter the Ca[Formula: see text] kinetics. We derive analytic results for the photoreceptor functioning in sufficiently dim light conditions depending on the photoreceptor type. We exploit these results to obtain conceptual and quantitative insight into how response waveform and amplitude depend on the underlying biophysical processes and the Ca[Formula: see text] feedback. With a low amount of buffering, the Ca[Formula: see text] concentration changes in proportion to the current, and responses to flashes of light are monophasic. With more buffering, the change in the Ca[Formula: see text] concentration becomes delayed with respect to the current, which gives rise to a damped oscillation and a biphasic waveform. This shows that biphasic responses are not necessarily a manifestation of slow buffering reactions. We obtain analytic approximations for the peak flash amplitude as a function of the light intensity, which shows how the photoreceptor sensitivity depends on the biophysical parameters. Finally, we study how changing the extracellular Ca[Formula: see text] concentration affects the response." @default.
• W4387563521 created "2023-10-13" @default.
• W4387563521 creator A5011943162 @default.
• W4387563521 creator A5028867664 @default.
• W4387563521 date "2023-10-12" @default.
• W4387563521 modified "2023-10-15" @default.
• W4387563521 title "Analysis of dim-light responses in rod and cone photoreceptors with altered calcium kinetics" @default.
• W4387563521 cites W130871477 @default.
• W4387563521 cites W138760565 @default.
• W4387563521 cites W1487220930 @default.
• W4387563521 cites W1509709236 @default.
• W4387563521 cites W1624087405 @default.
• W4387563521 cites W1910331461 @default.
• W4387563521 cites W1923432172 @default.
• W4387563521 cites W1967762840 @default.
• W4387563521 cites W1969167133 @default.
• W4387563521 cites W1970783550 @default.
• W4387563521 cites W1971427128 @default.
• W4387563521 cites W1972988663 @default.
• W4387563521 cites W1973121755 @default.
• W4387563521 cites W1974191268 @default.
• W4387563521 cites W1977847223 @default.
• W4387563521 cites W1978281876 @default.
• W4387563521 cites W1981783083 @default.
• W4387563521 cites W1987702850 @default.
• W4387563521 cites W1989433038 @default.
• W4387563521 cites W1989701128 @default.
• W4387563521 cites W1990153078 @default.
• W4387563521 cites W1994348876 @default.
• W4387563521 cites W1997328693 @default.
• W4387563521 cites W1998029597 @default.
• W4387563521 cites W1998403030 @default.
• W4387563521 cites W2001102624 @default.
• W4387563521 cites W2003062992 @default.
• W4387563521 cites W2004697473 @default.
• W4387563521 cites W2006340149 @default.
• W4387563521 cites W2014899116 @default.
• W4387563521 cites W2019075169 @default.
• W4387563521 cites W2019447882 @default.
• W4387563521 cites W2024664315 @default.
• W4387563521 cites W2025854429 @default.
• W4387563521 cites W2026472000 @default.
• W4387563521 cites W2030114330 @default.
• W4387563521 cites W2032741875 @default.
• W4387563521 cites W2046140095 @default.
• W4387563521 cites W2047057288 @default.
• W4387563521 cites W2057424241 @default.
• W4387563521 cites W2071968738 @default.
• W4387563521 cites W2073513922 @default.
• W4387563521 cites W2075235335 @default.
• W4387563521 cites W2075899918 @default.
• W4387563521 cites W2082411432 @default.
• W4387563521 cites W2085514362 @default.
• W4387563521 cites W2088144784 @default.
• W4387563521 cites W2089644939 @default.
• W4387563521 cites W2091000566 @default.
• W4387563521 cites W2091521215 @default.
• W4387563521 cites W2093475470 @default.
• W4387563521 cites W2094205096 @default.
• W4387563521 cites W2105846329 @default.
• W4387563521 cites W2111993777 @default.
• W4387563521 cites W2113215715 @default.
• W4387563521 cites W2115734536 @default.
• W4387563521 cites W2117856917 @default.
• W4387563521 cites W2118664588 @default.
• W4387563521 cites W2122833172 @default.
• W4387563521 cites W2123677773 @default.
• W4387563521 cites W2123786825 @default.
• W4387563521 cites W2126614849 @default.
• W4387563521 cites W2126666532 @default.
• W4387563521 cites W2127238314 @default.
• W4387563521 cites W2130293499 @default.
• W4387563521 cites W2134675152 @default.
• W4387563521 cites W2134950472 @default.
• W4387563521 cites W2140517867 @default.
• W4387563521 cites W2142913230 @default.
• W4387563521 cites W2145287390 @default.
• W4387563521 cites W2146048430 @default.
• W4387563521 cites W2148157275 @default.
• W4387563521 cites W2148658703 @default.
• W4387563521 cites W2150320598 @default.
• W4387563521 cites W2154130938 @default.
• W4387563521 cites W2159578432 @default.
• W4387563521 cites W2161318689 @default.
• W4387563521 cites W2166556622 @default.
• W4387563521 cites W2166571796 @default.
• W4387563521 cites W2166822400 @default.
• W4387563521 cites W2405272060 @default.
• W4387563521 cites W2461560513 @default.
• W4387563521 cites W2796821744 @default.
• W4387563521 cites W2805139026 @default.
• W4387563521 cites W2976053079 @default.
• W4387563521 cites W3000331040 @default.
• W4387563521 cites W3035827608 @default.
• W4387563521 cites W3052972144 @default.
• W4387563521 cites W3160483366 @default.
• W4387563521 cites W3173255533 @default.
• W4387563521 cites W3210707518 @default.
• W4387563521 cites W4205946464 @default.
• W4387563521 cites W4211200123 @default.

• next