FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387563556> ?p ?o ?g. }

• W4387563556 abstract "Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by behavioral, cognitive, and progressive memory impairments. Extensive neuronal loss, extracellular accumulation of insoluble senile amyloid-β (Aβ) plaques, and intracellular neurofibrillary tangles (NFTs) are the major pathological features. The present study aimed to investigate the therapeutic effect of donepezil (DON) and pentoxifylline (PTX) in combination to combat the neurodegenerative disorders (experimental AD) induced by CuSO4 intake in experimental rats. Thirty adult male Wistar rats (140-160 g) were used in this study. AD was first induced in rats by CuSO4 supplement to drinking water (10 mg/L) for 14 weeks. The AD group received no further treatment. Oral treatment with DON (10 mg/kg/day), PTX (100 mg/kg/day), or DON + PTX for the other three groups was started from the 10th week of CuSO4 intake for 4 weeks. Cortex markers like acetylcholine (ACh), acetylcholinesterase (AChE), total antioxidant capacity (TAC), and malondialdehyde (MDA) and hippocampus markers like β-amyloid precursor protein cleaving enzyme 1 (BACE1), phosphorylated Tau (p-tau), Clusterin (CLU), tumor necrosis factor-α (TNF-α), caspase-9 (CAS-9), Bax, and Bcl-2 were measured. The histopathology studies were done by using hematoxylin and eosin and Congo red stains as well as immunohistochemistry for neurofilament. CuSO4 induced adverse histological and biochemical changes. The histological injury in the hippocampus was inhibited following the administration of the DON and PTX. The brain tissue levels of AChE, MDA, BACE1, p-tau, CLU, CAS-9, Bax, and TNF-α were significantly increased, while brain tissue levels of ACh, TAC, and Bcl-2 were significantly decreased in CuSO4-treated rats as compared with the untreated control group. The effects induced by either DON or PTX on most studied parameters were comparable. Combined treatment of DON and PTX induced remarkable results compared with their individual use. However, more clinical and preclinical studies are still required to further confirm and prove the long-term efficacy of such combination." @default.
• W4387563556 created "2023-10-13" @default.
• W4387563556 creator A5021323780 @default.
• W4387563556 creator A5029102291 @default.
• W4387563556 creator A5029441915 @default.
• W4387563556 creator A5041352463 @default.
• W4387563556 creator A5078482783 @default.
• W4387563556 date "2023-10-12" @default.
• W4387563556 modified "2023-10-13" @default.
• W4387563556 title "Pentoxifylline as Add-On Treatment to Donepezil in Copper Sulphate-Induced Alzheimer’s Disease-Like Neurodegeneration in Rats" @default.
• W4387563556 cites W1591134912 @default.
• W4387563556 cites W1798984331 @default.
• W4387563556 cites W186149320 @default.
• W4387563556 cites W1983701594 @default.
• W4387563556 cites W1990290618 @default.
• W4387563556 cites W1993426606 @default.
• W4387563556 cites W2004010618 @default.
• W4387563556 cites W2013775559 @default.
• W4387563556 cites W2014473727 @default.
• W4387563556 cites W2017457068 @default.
• W4387563556 cites W2017889639 @default.
• W4387563556 cites W2028199124 @default.
• W4387563556 cites W2029190339 @default.
• W4387563556 cites W2034386801 @default.
• W4387563556 cites W2052613003 @default.
• W4387563556 cites W2053351407 @default.
• W4387563556 cites W2065505692 @default.
• W4387563556 cites W2074423172 @default.
• W4387563556 cites W2079873627 @default.
• W4387563556 cites W2083715632 @default.
• W4387563556 cites W2096963202 @default.
• W4387563556 cites W2100026237 @default.
• W4387563556 cites W2110966496 @default.
• W4387563556 cites W2111797988 @default.
• W4387563556 cites W2113154138 @default.
• W4387563556 cites W2117726740 @default.
• W4387563556 cites W2130473558 @default.
• W4387563556 cites W2140665078 @default.
• W4387563556 cites W2146602519 @default.
• W4387563556 cites W2154755614 @default.
• W4387563556 cites W2157380353 @default.
• W4387563556 cites W2164201168 @default.
• W4387563556 cites W2169070397 @default.
• W4387563556 cites W2261425572 @default.
• W4387563556 cites W2283080431 @default.
• W4387563556 cites W2325897769 @default.
• W4387563556 cites W2410314971 @default.
• W4387563556 cites W2418421474 @default.
• W4387563556 cites W2513250953 @default.
• W4387563556 cites W2564580703 @default.
• W4387563556 cites W2565780052 @default.
• W4387563556 cites W2743627045 @default.
• W4387563556 cites W2753636297 @default.
• W4387563556 cites W2760195442 @default.
• W4387563556 cites W2778166987 @default.
• W4387563556 cites W2793307595 @default.
• W4387563556 cites W2811135471 @default.
• W4387563556 cites W2891774391 @default.
• W4387563556 cites W2938694224 @default.
• W4387563556 cites W2948158985 @default.
• W4387563556 cites W2954406194 @default.
• W4387563556 cites W2980840983 @default.
• W4387563556 cites W2991069615 @default.
• W4387563556 cites W2994911649 @default.
• W4387563556 cites W3008683004 @default.
• W4387563556 cites W3031315118 @default.
• W4387563556 cites W3081470197 @default.
• W4387563556 cites W3083270987 @default.
• W4387563556 cites W3092191024 @default.
• W4387563556 cites W3162485704 @default.
• W4387563556 cites W3165986740 @default.
• W4387563556 cites W3196735179 @default.
• W4387563556 cites W3214027323 @default.
• W4387563556 cites W4210307005 @default.
• W4387563556 cites W4214587366 @default.
• W4387563556 cites W4281762214 @default.
• W4387563556 doi "https://doi.org/10.1007/s12640-023-00672-1" @default.
• W4387563556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37821782" @default.
• W4387563556 hasPublicationYear "2023" @default.
• W4387563556 type Work @default.
• W4387563556 citedByCount "0" @default.
• W4387563556 crossrefType "journal-article" @default.
• W4387563556 hasAuthorship W4387563556A5021323780 @default.
• W4387563556 hasAuthorship W4387563556A5029102291 @default.
• W4387563556 hasAuthorship W4387563556A5029441915 @default.
• W4387563556 hasAuthorship W4387563556A5041352463 @default.
• W4387563556 hasAuthorship W4387563556A5078482783 @default.
• W4387563556 hasBestOaLocation W43875635561 @default.
• W4387563556 hasConcept C126322002 @default.
• W4387563556 hasConcept C134018914 @default.
• W4387563556 hasConcept C142724271 @default.
• W4387563556 hasConcept C181199279 @default.
• W4387563556 hasConcept C185592680 @default.
• W4387563556 hasConcept C204232928 @default.
• W4387563556 hasConcept C2776151105 @default.
• W4387563556 hasConcept C2776925932 @default.
• W4387563556 hasConcept C2777209535 @default.
• W4387563556 hasConcept C2778401633 @default.
• W4387563556 hasConcept C2778816929 @default.
• W4387563556 hasConcept C2779134260 @default.

• next