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- W4387563619 abstract "Blood flow in large veins is dependent on arterial-atrial pressure gradients and pumping mechanisms in concert with valve recruitment. Classic descriptions of muscle and respiratory pumps describe venous transmural pressure changes that cause flow. Not often considered is the transmission of pulsatile energy from arteries to veins directly adjacent to each other. Recently, an ex vivo study demonstrated a novel arterial pump effect in veno-arterial bundles when valves were active in managing venous flow. We sought to show in vivo evidence of this arterial pump mechanism in 16 healthy, young adults. Venous blood flow was measured in the veno-arterial bundled deep femoral vein (DFV) and the greater saphenous vein (GSV), which is not bundled with an artery. Veins were studied through randomized body positions of -6° head-down tilt (HDT), supine, 20° head-up tilt (HUT), and 40° HUT, with the assumption that greater HUT postures increased valve dependence to observe the arterial pump effect. Between 20° and 40° HUT conditions, bundled DFV blood flow did not change (68±36 vs. 71±56 mL·min-1; Padj>0.99), whereas unbundled GSV blood flow decreased (6.1±4.8 vs. 3.5±3.9 mL·min-1; P=0.01). Diameters between 20° and 40° HUT conditions increased in DFV (0.90±0.16 vs. 1.04±0.19 cm; P<0.01), but not GSV (0.33±0.10 vs. 0.32±0.08 cm; P=0.60). These data support previous ex vivo observations that when venous pressure gradients rely on valve recruitment, presence of an adjacent artery may protect against further decreases in blood flow. The arterial pump mechanism is an underappreciated contributor to venous return and warrants further investigation." @default.
- W4387563619 created "2023-10-13" @default.
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- W4387563619 date "2023-10-12" @default.
- W4387563619 modified "2023-10-13" @default.
- W4387563619 title "Supporting evidence for an 'arterial pump' venous return mechanism in humans" @default.
- W4387563619 doi "https://doi.org/10.1152/japplphysiol.00480.2023" @default.
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- W4387563619 hasPublicationYear "2023" @default.
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