Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387563744> ?p ?o ?g. }
- W4387563744 abstract "Tau protein was discovered as a microtubule-associated protein nearly 50 years ago, and our understanding of tau has revolved around that role. Even with tau's rise to stardom as a central player in neurodegenerative disease, therapeutic efforts have largely been targeted toward cytoskeletal changes. While some studies hinted toward non-cytoskeletal roles for tau, it is only fairly recently that these ideas have begun to receive considerable attention. Many new binding partners for tau have been identified, including DNA, RNA, RNA-binding proteins, some receptors, and other tau molecules. The diversity of tau binding partners coupled with the discovery of tau other than axonal compartments such as nucleus, dendrites, and synapses have led to the proposal of novel functions for tau in roles such as nuclear stability, cell signaling, transcriptional processing, and protein synthesis. Tau self-assembly in particular has made an impact, leading to the hypothesis that a prion-like function of hyperphosphorylated tau is central to tauopathies. With tau emerging as a multifaceted protein that operates in many parts of the cell and with many molecular partners, the field of tau biology is primed for discoveries that can provide new perspectives on both the unique biochemistry of tau and the nature of devastating neurological diseases." @default.
- W4387563744 created "2023-10-13" @default.
- W4387563744 creator A5004330069 @default.
- W4387563744 creator A5053987011 @default.
- W4387563744 creator A5062557962 @default.
- W4387563744 creator A5068563709 @default.
- W4387563744 creator A5076550585 @default.
- W4387563744 date "2023-10-11" @default.
- W4387563744 modified "2023-10-13" @default.
- W4387563744 title "Tau: More than a microtubule‐binding protein in neurons" @default.
- W4387563744 cites W1482146746 @default.
- W4387563744 cites W1555289101 @default.
- W4387563744 cites W1581400671 @default.
- W4387563744 cites W1858579514 @default.
- W4387563744 cites W1862556038 @default.
- W4387563744 cites W1964476920 @default.
- W4387563744 cites W1966339053 @default.
- W4387563744 cites W1968372370 @default.
- W4387563744 cites W1969979382 @default.
- W4387563744 cites W1975040221 @default.
- W4387563744 cites W1989208474 @default.
- W4387563744 cites W2000303735 @default.
- W4387563744 cites W2004371219 @default.
- W4387563744 cites W2006588853 @default.
- W4387563744 cites W2006717582 @default.
- W4387563744 cites W2021460489 @default.
- W4387563744 cites W2022573011 @default.
- W4387563744 cites W2037761115 @default.
- W4387563744 cites W2043712143 @default.
- W4387563744 cites W2055371691 @default.
- W4387563744 cites W2069123600 @default.
- W4387563744 cites W2071203165 @default.
- W4387563744 cites W2071448260 @default.
- W4387563744 cites W2074769970 @default.
- W4387563744 cites W2079203774 @default.
- W4387563744 cites W2081966615 @default.
- W4387563744 cites W2091347920 @default.
- W4387563744 cites W2109355761 @default.
- W4387563744 cites W2112136536 @default.
- W4387563744 cites W2120701804 @default.
- W4387563744 cites W2123406821 @default.
- W4387563744 cites W2135348375 @default.
- W4387563744 cites W2142118427 @default.
- W4387563744 cites W2155048015 @default.
- W4387563744 cites W2158323020 @default.
- W4387563744 cites W2159377066 @default.
- W4387563744 cites W2168681379 @default.
- W4387563744 cites W2226786300 @default.
- W4387563744 cites W2302116106 @default.
- W4387563744 cites W2327550735 @default.
- W4387563744 cites W2331819283 @default.
- W4387563744 cites W2514975062 @default.
- W4387563744 cites W2757013050 @default.
- W4387563744 cites W2788659688 @default.
- W4387563744 cites W2815697343 @default.
- W4387563744 cites W2896801782 @default.
- W4387563744 cites W2904237875 @default.
- W4387563744 cites W2914774683 @default.
- W4387563744 cites W2966917013 @default.
- W4387563744 cites W2969422239 @default.
- W4387563744 cites W2977383991 @default.
- W4387563744 cites W2980925175 @default.
- W4387563744 cites W2990623187 @default.
- W4387563744 cites W3017497569 @default.
- W4387563744 cites W3044114834 @default.
- W4387563744 cites W3137043988 @default.
- W4387563744 cites W3173409805 @default.
- W4387563744 cites W3197490415 @default.
- W4387563744 cites W3205310051 @default.
- W4387563744 cites W4200062336 @default.
- W4387563744 cites W4212924105 @default.
- W4387563744 cites W4225311917 @default.
- W4387563744 cites W4225544513 @default.
- W4387563744 cites W4225983549 @default.
- W4387563744 cites W4281743018 @default.
- W4387563744 cites W4306404334 @default.
- W4387563744 cites W864036077 @default.
- W4387563744 doi "https://doi.org/10.1002/cm.21795" @default.
- W4387563744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37819542" @default.
- W4387563744 hasPublicationYear "2023" @default.
- W4387563744 type Work @default.
- W4387563744 citedByCount "0" @default.
- W4387563744 crossrefType "journal-article" @default.
- W4387563744 hasAuthorship W4387563744A5004330069 @default.
- W4387563744 hasAuthorship W4387563744A5053987011 @default.
- W4387563744 hasAuthorship W4387563744A5062557962 @default.
- W4387563744 hasAuthorship W4387563744A5068563709 @default.
- W4387563744 hasAuthorship W4387563744A5076550585 @default.
- W4387563744 hasBestOaLocation W43875637441 @default.
- W4387563744 hasConcept C14036430 @default.
- W4387563744 hasConcept C142669718 @default.
- W4387563744 hasConcept C142724271 @default.
- W4387563744 hasConcept C1491633281 @default.
- W4387563744 hasConcept C169760540 @default.
- W4387563744 hasConcept C20418707 @default.
- W4387563744 hasConcept C2778670691 @default.
- W4387563744 hasConcept C2779134260 @default.
- W4387563744 hasConcept C502032728 @default.
- W4387563744 hasConcept C54355233 @default.
- W4387563744 hasConcept C61081601 @default.