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- W4387563749 abstract "Diffusion-weighted MRI (dMRI) is a medical imaging method that can be used to investigate the brain microstructure and structural connections between different brain regions. The method, however, requires relatively complex data processing frameworks and analysis pipelines. Many of these approaches are vulnerable to signal dropout artefacts that can originate from subjects moving their head during the scan. To combat these artefacts and eliminate such outliers, researchers have proposed two approaches: to replace outliers or to downweight outliers during modelling and analysis. With the rising interest in dMRI for clinical research, these types of corrections are increasingly important. Therefore, we set out to investigate the differences between outlier replacement and weighting approaches to help the dMRI community to select the best tool for their data processing pipelines. We evaluated dMRI motion correction registration and single tensor model fit pipelines using Gaussian Process and Spherical Harmonic based replacement approaches and outlier downweighting using highly realistic whole-brain simulations. As a proof of concept, we applied these approaches to dMRI infant data sets that contained varying numbers of dropout artefacts. Based on our results, we concluded that the Gaussian Process based outlier replacement provided similar tensor fit results to Gaussian Process based outlier detection and downweighting. Therefore, if only the least-squares estimate of the single tensor model is of interest, our recommendation is to use outlier replacement. However, outlier downweighting can potentially provide a more accurate estimate of the model precision which could be relevant for applications such as probabilistic tractoraphy." @default.
- W4387563749 created "2023-10-13" @default.
- W4387563749 creator A5022288143 @default.
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- W4387563749 date "2023-10-09" @default.
- W4387563749 modified "2023-10-13" @default.
- W4387563749 title "Outliers in diffusion-weighted MRI: Exploring detection models and mitigation strategies." @default.
- W4387563749 doi "https://doi.org/10.1016/j.neuroimage.2023.120397" @default.
- W4387563749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37820862" @default.
- W4387563749 hasPublicationYear "2023" @default.
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