Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387563792> ?p ?o ?g. }
- W4387563792 abstract "Androgen deprivation therapy is a common treatment method for metastatic prostate cancer through lowering androgen levels; however, this therapy frequently leads to the development of castration-resistant prostate cancer (CRPC). This is attributed to the activation of the androgen receptor (AR) signaling pathway. Current treatments targeting AR are often ineffective mostly due to AR gene overexpression and mutations, as well as the presence of splice variants that accelerate CRPC progression. Thus there is a critical need for more specific medication to treat CRPC. Small interfering RNAs have shown great potential as a targeted therapy. This review discusses prostate cancer progression and the role of AR signaling in CRPC, and proposes siRNA-based targeted therapy as a promising strategy for CRPC." @default.
- W4387563792 created "2023-10-13" @default.
- W4387563792 creator A5002506977 @default.
- W4387563792 creator A5012995073 @default.
- W4387563792 creator A5013264727 @default.
- W4387563792 creator A5020611548 @default.
- W4387563792 creator A5024337072 @default.
- W4387563792 creator A5034532201 @default.
- W4387563792 creator A5047721028 @default.
- W4387563792 creator A5055240490 @default.
- W4387563792 creator A5069380261 @default.
- W4387563792 creator A5087000257 @default.
- W4387563792 date "2023-10-12" @default.
- W4387563792 modified "2023-10-13" @default.
- W4387563792 title "siRNA-based approaches for castration-resistant prostate cancer therapy targeting the androgen receptor signaling pathway" @default.
- W4387563792 cites W1907272683 @default.
- W4387563792 cites W1963935560 @default.
- W4387563792 cites W1967828043 @default.
- W4387563792 cites W1968786809 @default.
- W4387563792 cites W1969556504 @default.
- W4387563792 cites W1972459670 @default.
- W4387563792 cites W1977494962 @default.
- W4387563792 cites W1982552468 @default.
- W4387563792 cites W1985360090 @default.
- W4387563792 cites W1988051690 @default.
- W4387563792 cites W1988285678 @default.
- W4387563792 cites W1989656600 @default.
- W4387563792 cites W2004273376 @default.
- W4387563792 cites W2015306991 @default.
- W4387563792 cites W2021497980 @default.
- W4387563792 cites W2032165027 @default.
- W4387563792 cites W2032800737 @default.
- W4387563792 cites W2038199141 @default.
- W4387563792 cites W2041193073 @default.
- W4387563792 cites W2045292016 @default.
- W4387563792 cites W2051025382 @default.
- W4387563792 cites W2072335762 @default.
- W4387563792 cites W2084891840 @default.
- W4387563792 cites W2090983051 @default.
- W4387563792 cites W2093549201 @default.
- W4387563792 cites W2096021660 @default.
- W4387563792 cites W2097226696 @default.
- W4387563792 cites W2107151134 @default.
- W4387563792 cites W2120361393 @default.
- W4387563792 cites W2128204487 @default.
- W4387563792 cites W2134298234 @default.
- W4387563792 cites W2138704678 @default.
- W4387563792 cites W2139695668 @default.
- W4387563792 cites W2139718640 @default.
- W4387563792 cites W2140388664 @default.
- W4387563792 cites W2144941480 @default.
- W4387563792 cites W2145331231 @default.
- W4387563792 cites W2150775704 @default.
- W4387563792 cites W2157158939 @default.
- W4387563792 cites W2158567574 @default.
- W4387563792 cites W2160463964 @default.
- W4387563792 cites W2161123101 @default.
- W4387563792 cites W2163170981 @default.
- W4387563792 cites W2164735763 @default.
- W4387563792 cites W2167331614 @default.
- W4387563792 cites W2171450779 @default.
- W4387563792 cites W2176061850 @default.
- W4387563792 cites W2181283187 @default.
- W4387563792 cites W2183117764 @default.
- W4387563792 cites W2216033157 @default.
- W4387563792 cites W2340243550 @default.
- W4387563792 cites W2475556897 @default.
- W4387563792 cites W2481923805 @default.
- W4387563792 cites W2491436916 @default.
- W4387563792 cites W2531825284 @default.
- W4387563792 cites W2540537925 @default.
- W4387563792 cites W2568836017 @default.
- W4387563792 cites W2571455926 @default.
- W4387563792 cites W2581170664 @default.
- W4387563792 cites W2596065753 @default.
- W4387563792 cites W2611741716 @default.
- W4387563792 cites W2736868640 @default.
- W4387563792 cites W2754574141 @default.
- W4387563792 cites W2775560499 @default.
- W4387563792 cites W2776294275 @default.
- W4387563792 cites W2782790872 @default.
- W4387563792 cites W2783564763 @default.
- W4387563792 cites W2789931394 @default.
- W4387563792 cites W2790816372 @default.
- W4387563792 cites W2816475751 @default.
- W4387563792 cites W2841328798 @default.
- W4387563792 cites W2885305111 @default.
- W4387563792 cites W2889483924 @default.
- W4387563792 cites W2891532655 @default.
- W4387563792 cites W2893168313 @default.
- W4387563792 cites W2894741998 @default.
- W4387563792 cites W2897146989 @default.
- W4387563792 cites W2897635524 @default.
- W4387563792 cites W2903444830 @default.
- W4387563792 cites W2908533946 @default.
- W4387563792 cites W2911632317 @default.
- W4387563792 cites W2922124339 @default.
- W4387563792 cites W2937407467 @default.
- W4387563792 cites W2941423741 @default.
- W4387563792 cites W2943769781 @default.