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• W4387563823 abstract "PKD1 (polycystin 1) and PKD2 (polycystin 2) are expressed in a variety of different cell types, including arterial smooth muscle and endothelial cells. PKD1 is a transmembrane domain protein with a large extracellular N-terminus that is proposed to act as a mechanosensor and receptor. PKD2 is a member of the transient receptor potential (TRP) channel superfamily which is also termed TRPP1. Mutations in the genes which encode PKD1 and PKD2 lead to autosomal polycystic kidney disease (ADPKD). ADPKD is one of the most prevalent monogenic disorders in humans and is associated with extrarenal and vascular complications, including hypertension. Recent studies have uncovered mechanisms of activation and physiological functions of PKD1 and PKD2 in arterial smooth muscle and endothelial cells. It has also been found that PKD function is altered in the vasculature during ADPKD and hypertension. We will summarize this work and discuss future possibilities for this area of research." @default.
• W4387563823 created "2023-10-13" @default.
• W4387563823 creator A5018134952 @default.
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• W4387563823 date "2023-10-12" @default.
• W4387563823 modified "2023-10-13" @default.
• W4387563823 title "Vascular polycystin proteins in health and disease" @default.
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• W4387563823 doi "https://doi.org/10.1111/micc.12834" @default.
• W4387563823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37823335" @default.
• W4387563823 hasPublicationYear "2023" @default.
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