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- W4387563854 abstract "The submandibular gland (SMG) and sublingual gland (SLG) are two of the three major salivary glands in mammals and comprise serous and mucous acinar cells. The two glands share some functional properties, which are largely dependent on the types of acinar cells. In recent years, while ScRNA-seq (single-cell sequencing) with a 10 × platform has been used to explore molecular markers in salivary glands, few studies have examined the acinar heterogeneity and unique molecular markers between SMG and SLG. This study aimed to identify the molecular markers of acinar cells in the SLG and SMG. We performed ScRNA-seq analyses in 4 weeks (W) old mice and verified the screened molecular markers using RT-qPCR, immunohistochemistry, and immunofluorescence. Our results showed prominently heterogeneous acinar cells, although there was a great similarity in the cluster composition between the two glands at 4 W. Furthermore, we demonstrated that Agt is a specific marker of SMG serous acinar cells, whereas Gal is a specific marker of SLG mucous acinar cells. Trajectory inference revealed that Agt and Gal represent two types of differential acinar cell clusters during late development in adults.Thus, we reveal previously unknown specific markers for salivary acinar cell diversity that has extensive implications for their further functional research." @default.
- W4387563854 created "2023-10-13" @default.
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- W4387563854 date "2023-10-12" @default.
- W4387563854 modified "2023-10-17" @default.
- W4387563854 title "Single cell RNA-seq analysis identifies angiotensinogen and galanin as unique molecular markers of acinar cells in murine salivary glands" @default.
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- W4387563854 doi "https://doi.org/10.1089/scd.2023.0125" @default.
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