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• W4387564392 abstract "In 2005, a nationwide program of iodine prophylaxis on voluntary basis was implemented in Italy by law. However, recent data on iodine status are lacking.The aim of this study was to evaluate efficiency, effectiveness, and possible adverse effects (increased occurrence of thyroid autoimmunity and hyperthyroidism) of the Italian iodine prophylaxis program.In the period 2015-2019 a nationwide survey was performed. The use of iodized salt was evaluated in a sample of 164,593 adults and in 998 school canteens. A sample of 4,233 schoolchildren (11-13 years) was recruited to assess urinary iodine concentration (UIC), prevalence of goiter and thyroid hypoechogenicity on ultrasound. The latter as an indirect indicator of thyroid autoimmunity. Neonatal TSH values of 197,677 infants screened in regions representative of Northern, Central, and Southern Italy were analyzed to investigate the percentage of TSH values >5.0 mIU/L. Data on methimazole prescriptions were analyzed as indirect indicator of new cases of hyperthyroidism.The prevalence of the use of iodized salt was 71.5% in adult population and 78% in school canteens. A median UIC of 124 μg/L, a prevalence of goiter of 2.2%, and a prevalence of thyroid hypoechogenicity of 5.7% were observed in schoolchildren. The percentage of neonatal TSH values >5.0 mIU/L resulted still higher (5.1%) than the WHO threshold of 3.0%; whereas the prescriptions of methimazole showed a reduction of 13.5%.Fifteen years of iodine prophylaxis have led to iodine sufficiency in Italy, although there still is concern about iodine nutritional status during pregnancy." @default.
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• W4387564392 date "2023-10-11" @default.
• W4387564392 modified "2023-10-13" @default.
• W4387564392 title "Fifteen Years of Iodine Prophylaxis in Italy: Results of a Nationwide Surveillance (Period 2015-2019)" @default.
• W4387564392 doi "https://doi.org/10.1210/clinem/dgad593" @default.
• W4387564392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37820735" @default.
• W4387564392 hasPublicationYear "2023" @default.
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