Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387564397> ?p ?o ?g. }
- W4387564397 abstract "Antithrombin (AT) is a natural anticoagulant pivotal in inactivating serine protease enzymes in the coagulation cascade, making it a potent inhibitor of blood clot formation. AT also possesses anti-inflammatory properties by influencing anticoagulation and directly interacting with endothelial cells. Hereditary AT deficiency is one of the most severe inherited thrombophilias, with up to 85% lifetime risk of venous thromboembolism. Acquired AT deficiency arises during heparin therapy or states of hypercoagulability like sepsis and premature infancy. Optimization of AT levels in individuals with AT deficiency is an important treatment consideration, particularly during high-risk situations such as surgery, trauma, pregnancy, and postpartum. Here, we integrate the existing evidence surrounding the approved uses of AT therapy, as well as potential additional patient populations where AT therapy has been considered by the medical community, including any available consensus statements and guidelines. We also describe current knowledge regarding cost-effectiveness of AT concentrate in different contexts. Future work should seek to identify specific patient populations for whom targeted AT therapy is likely to provide the strongest clinical benefit." @default.
- W4387564397 created "2023-10-13" @default.
- W4387564397 creator A5002698865 @default.
- W4387564397 creator A5035173382 @default.
- W4387564397 date "2023-01-01" @default.
- W4387564397 modified "2023-10-15" @default.
- W4387564397 title "Antithrombin Therapy: Current State and Future Outlook" @default.
- W4387564397 cites W141661929 @default.
- W4387564397 cites W1482452342 @default.
- W4387564397 cites W1504555330 @default.
- W4387564397 cites W155680908 @default.
- W4387564397 cites W1574141134 @default.
- W4387564397 cites W1606979836 @default.
- W4387564397 cites W1713440487 @default.
- W4387564397 cites W184175959 @default.
- W4387564397 cites W1963808445 @default.
- W4387564397 cites W1977435299 @default.
- W4387564397 cites W1988178206 @default.
- W4387564397 cites W1989317042 @default.
- W4387564397 cites W1989560973 @default.
- W4387564397 cites W1996624351 @default.
- W4387564397 cites W1999266969 @default.
- W4387564397 cites W2002193432 @default.
- W4387564397 cites W2013864258 @default.
- W4387564397 cites W2018745526 @default.
- W4387564397 cites W2019027259 @default.
- W4387564397 cites W2019584577 @default.
- W4387564397 cites W2019818341 @default.
- W4387564397 cites W2022132254 @default.
- W4387564397 cites W2026263242 @default.
- W4387564397 cites W2026274122 @default.
- W4387564397 cites W2041625430 @default.
- W4387564397 cites W2043330626 @default.
- W4387564397 cites W2049036705 @default.
- W4387564397 cites W2057118034 @default.
- W4387564397 cites W2061522758 @default.
- W4387564397 cites W2065697699 @default.
- W4387564397 cites W2066357874 @default.
- W4387564397 cites W2066441197 @default.
- W4387564397 cites W2076324509 @default.
- W4387564397 cites W2078586062 @default.
- W4387564397 cites W2079260184 @default.
- W4387564397 cites W2081689955 @default.
- W4387564397 cites W2082416969 @default.
- W4387564397 cites W2085353781 @default.
- W4387564397 cites W2091246132 @default.
- W4387564397 cites W2095746088 @default.
- W4387564397 cites W2095889376 @default.
- W4387564397 cites W2096320106 @default.
- W4387564397 cites W2097682287 @default.
- W4387564397 cites W2099228074 @default.
- W4387564397 cites W2101082552 @default.
- W4387564397 cites W2105467554 @default.
- W4387564397 cites W2106459062 @default.
- W4387564397 cites W2115105735 @default.
- W4387564397 cites W2115262523 @default.
- W4387564397 cites W2115301416 @default.
- W4387564397 cites W2126431109 @default.
- W4387564397 cites W2127103113 @default.
- W4387564397 cites W2127697894 @default.
- W4387564397 cites W2138612542 @default.
- W4387564397 cites W2149794686 @default.
- W4387564397 cites W2151060265 @default.
- W4387564397 cites W2155154384 @default.
- W4387564397 cites W2166258616 @default.
- W4387564397 cites W2170237889 @default.
- W4387564397 cites W2171029622 @default.
- W4387564397 cites W2201030059 @default.
- W4387564397 cites W2236393536 @default.
- W4387564397 cites W2238441516 @default.
- W4387564397 cites W2272401759 @default.
- W4387564397 cites W2272987617 @default.
- W4387564397 cites W2280404143 @default.
- W4387564397 cites W2285071347 @default.
- W4387564397 cites W2296953840 @default.
- W4387564397 cites W2328527018 @default.
- W4387564397 cites W2343741170 @default.
- W4387564397 cites W2344498967 @default.
- W4387564397 cites W2394601116 @default.
- W4387564397 cites W2404364295 @default.
- W4387564397 cites W2410839454 @default.
- W4387564397 cites W2410900854 @default.
- W4387564397 cites W2414431822 @default.
- W4387564397 cites W2415707997 @default.
- W4387564397 cites W2417117352 @default.
- W4387564397 cites W2422135076 @default.
- W4387564397 cites W2471256249 @default.
- W4387564397 cites W2492780914 @default.
- W4387564397 cites W2517226777 @default.
- W4387564397 cites W2520678624 @default.
- W4387564397 cites W2556930376 @default.
- W4387564397 cites W2590123800 @default.
- W4387564397 cites W2592086722 @default.
- W4387564397 cites W2731474031 @default.
- W4387564397 cites W2752870662 @default.
- W4387564397 cites W2766211813 @default.
- W4387564397 cites W2781217924 @default.
- W4387564397 cites W2788496123 @default.
- W4387564397 cites W2801374493 @default.
- W4387564397 cites W2801382910 @default.