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• W4387564404 abstract "Neural stem/progenitor cells (NSPCs) are present in the mammalian brain throughout life and are involved in neurodevelopment and central nervous system repair. Although typical epigenetic signatures, including DNA methylation, histone modifications and microRNAs, play a pivotal role in the regulation of NSPCs, several of the epigenetic regulatory mechanisms of NSPCs remain unclear. Thus, defining a novel epigenetic feature of NSPCs is crucial for developing stem cell therapy to address neurologic disorders caused by injury. In this study, we aimed to define R-loops, a three-stranded nucleic acid structure, as an epigenetic characteristic of NSPCs during neurodevelopment. Our results demonstrated that R-loop levels change dynamically throughout neurodevelopment. Cells with high levels of R-loops consistently decreased and were enriched in the area of neurogenesis. Additionally, these cells co-stained with SOX2 during neurodevelopment. Furthermore, these high R-loop level cells expressed Ki-67 and exhibited a high degree of overlap with transcriptional activation markers H3K4me3, ser5, and H3K27ac. These findings suggest that R-loops may serve as an epigenetic feature for transcriptional activation in NSPCs, indicating their role in gene expression regulation and neurogenesis." @default.
• W4387564404 created "2023-10-13" @default.
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• W4387564404 date "2023-10-12" @default.
• W4387564404 modified "2023-10-13" @default.
• W4387564404 title "R-loop defines neural stem/progenitor cells during mouse neurodevelopment" @default.
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• W4387564404 doi "https://doi.org/10.1089/scd.2023.0196" @default.
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