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- W4387564560 abstract "Carbohydrates increase kidney stone risk and increase urine calcium and magnesium. We hypothesize that effects of glucose as an allosteric modulator of calcium-sensing receptor may mediate this effect. Six healthy subjects were on a low sodium diet before consuming 100 grams of glucose beverage. Timed fasting (3) and post-glucose (6) urine and blood samples were collected every 30-minutes. Urine composition and serum markers were measured and microvesicular abundance of tubular transport proteins (NHE3, NKCC2, NCC, and TRPV5) were quantified. Post-glucose, serum glucose and insulin rose rapidly with a parallel increase in calcium and magnesium excretion and no change in fractional excretion of sodium. Both serum parathyroid hormone (PTH) and urine TRPV5 fell in the post-glucose periods. The rise in the calcium and magnesium excretion likely occurred primarily in the thick ascending limb where they are both under control of the calcium-sensing receptor. The fall in PTH and TRPV5 support the role of glucose as an allosteric modulator of calcium sensing receptor." @default.
- W4387564560 created "2023-10-13" @default.
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- W4387564560 date "2023-10-12" @default.
- W4387564560 modified "2023-10-13" @default.
- W4387564560 title "Contribution of thick ascending limb and distal convoluted tubule to glucose induced hypercalciuria in healthy controls" @default.
- W4387564560 doi "https://doi.org/10.1152/ajprenal.00130.2023" @default.
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