Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387566775> ?p ?o ?g. }
- W4387566775 abstract "Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in ways that can be either beneficial or detrimental to disorder outcome. Pathophysiological changes in astroglia can be primary or secondary and can result in gain or loss of functions. Astroglia respond to external, non-cell autonomous signals associated with any form of CNS pathology by undergoing complex and variable changes in their structure, molecular expression, and function. In addition, internally driven, cell autonomous changes of astroglial innate properties can lead to CNS pathologies. Astroglial pathophysiology is complex, with different pathophysiological cell states and cell phenotypes that are context-specific and vary with disorder, disorder-stage, comorbidities, age, and sex. Here, we classify astroglial pathophysiology into (i) reactive astrogliosis, (ii) astroglial atrophy with loss of function, (iii) astroglial degeneration and death, and (iv) astrocytopathies characterised by aberrant forms that drive disease. We review astroglial pathophysiology across the spectrum of human CNS diseases and disorders, including neurotrauma, stroke, neuroinfection, autoimmune attack and epilepsy, as well as neurodevelopmental, neurodegenerative, metabolic and neuropsychiatric disorders. Characterising cellular and molecular mechanisms of astroglial pathophysiology represents a new frontier to identify novel therapeutic strategies." @default.
- W4387566775 created "2023-10-13" @default.
- W4387566775 creator A5011858801 @default.
- W4387566775 creator A5013454209 @default.
- W4387566775 creator A5014943822 @default.
- W4387566775 creator A5022130217 @default.
- W4387566775 creator A5025932270 @default.
- W4387566775 creator A5028318519 @default.
- W4387566775 creator A5040470106 @default.
- W4387566775 creator A5083227570 @default.
- W4387566775 date "2023-10-13" @default.
- W4387566775 modified "2023-10-15" @default.
- W4387566775 title "Astrocytes in human central nervous system diseases: a frontier for new therapies" @default.
- W4387566775 cites W1495968809 @default.
- W4387566775 cites W1500818454 @default.
- W4387566775 cites W1501699380 @default.
- W4387566775 cites W1513808048 @default.
- W4387566775 cites W1527856784 @default.
- W4387566775 cites W1541267199 @default.
- W4387566775 cites W1580693649 @default.
- W4387566775 cites W1594747697 @default.
- W4387566775 cites W1601132847 @default.
- W4387566775 cites W1603285606 @default.
- W4387566775 cites W1624592313 @default.
- W4387566775 cites W1733931174 @default.
- W4387566775 cites W1786188576 @default.
- W4387566775 cites W1815876215 @default.
- W4387566775 cites W1828576284 @default.
- W4387566775 cites W1832520743 @default.
- W4387566775 cites W1835889486 @default.
- W4387566775 cites W1864391669 @default.
- W4387566775 cites W1874238518 @default.
- W4387566775 cites W187643536 @default.
- W4387566775 cites W1880587390 @default.
- W4387566775 cites W1884999644 @default.
- W4387566775 cites W1896611699 @default.
- W4387566775 cites W1925771428 @default.
- W4387566775 cites W1963848219 @default.
- W4387566775 cites W1964319708 @default.
- W4387566775 cites W1964437757 @default.
- W4387566775 cites W1965044068 @default.
- W4387566775 cites W1968922340 @default.
- W4387566775 cites W1969305530 @default.
- W4387566775 cites W1969444386 @default.
- W4387566775 cites W1969619562 @default.
- W4387566775 cites W1969967491 @default.
- W4387566775 cites W1971125401 @default.
- W4387566775 cites W1971293133 @default.
- W4387566775 cites W1972579409 @default.
- W4387566775 cites W1973125755 @default.
- W4387566775 cites W1973334614 @default.
- W4387566775 cites W1973843890 @default.
- W4387566775 cites W1974272997 @default.
- W4387566775 cites W1975552740 @default.
- W4387566775 cites W1976775990 @default.
- W4387566775 cites W1977401897 @default.
- W4387566775 cites W1977808918 @default.
- W4387566775 cites W1977850361 @default.
- W4387566775 cites W1978453599 @default.
- W4387566775 cites W1979008433 @default.
- W4387566775 cites W1979964492 @default.
- W4387566775 cites W1980452558 @default.
- W4387566775 cites W1980626325 @default.
- W4387566775 cites W1981546185 @default.
- W4387566775 cites W1983638257 @default.
- W4387566775 cites W1983836947 @default.
- W4387566775 cites W1984213393 @default.
- W4387566775 cites W1985097707 @default.
- W4387566775 cites W1985228085 @default.
- W4387566775 cites W1985443373 @default.
- W4387566775 cites W1985691305 @default.
- W4387566775 cites W1985697148 @default.
- W4387566775 cites W1985989596 @default.
- W4387566775 cites W1986729839 @default.
- W4387566775 cites W1987586697 @default.
- W4387566775 cites W1987964841 @default.
- W4387566775 cites W1988216749 @default.
- W4387566775 cites W1988605914 @default.
- W4387566775 cites W1988766176 @default.
- W4387566775 cites W1989065264 @default.
- W4387566775 cites W1989598267 @default.
- W4387566775 cites W1990078383 @default.
- W4387566775 cites W1990216374 @default.
- W4387566775 cites W1990713194 @default.
- W4387566775 cites W1993979927 @default.
- W4387566775 cites W1994292318 @default.
- W4387566775 cites W1994668150 @default.
- W4387566775 cites W1994751580 @default.
- W4387566775 cites W1995111570 @default.
- W4387566775 cites W1995963726 @default.
- W4387566775 cites W1996024251 @default.
- W4387566775 cites W1998046507 @default.
- W4387566775 cites W1998256149 @default.
- W4387566775 cites W1998257450 @default.
- W4387566775 cites W1998338131 @default.
- W4387566775 cites W2000225222 @default.
- W4387566775 cites W2000868000 @default.
- W4387566775 cites W2000899855 @default.
- W4387566775 cites W2003982930 @default.
- W4387566775 cites W2004027184 @default.