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- W4387566782 endingPage "4709.e16" @default.
- W4387566782 startingPage "4694" @default.
- W4387566782 abstract "Cytoplasmic divisions are thought to rely on nuclear divisions and mitotic signals. We demonstrate in Drosophila embryos that cytoplasm can divide repeatedly without nuclei and mitotic CDK/cyclin complexes. Cdk1 normally slows an otherwise faster cytoplasmic division cycle, coupling it with nuclear divisions, and when uncoupled, cytoplasm starts dividing before mitosis. In developing embryos where CDK/cyclin activity can license mitotic microtubule (MT) organizers like the spindle, cytoplasmic divisions can occur without the centrosome, a principal organizer of interphase MTs. However, centrosomes become essential in the absence of CDK/cyclin activity, implying that the cytoplasm can employ either the centrosome-based interphase or CDK/cyclin-dependent mitotic MTs to facilitate its divisions. Finally, we present evidence that autonomous cytoplasmic divisions occur during unperturbed fly embryogenesis and that they may help extrude mitotically stalled nuclei during blastoderm formation. We postulate that cytoplasmic divisions occur in cycles governed by a yet-to-be-uncovered clock mechanism autonomous from CDK/cyclin complexes." @default.
- W4387566782 created "2023-10-13" @default.
- W4387566782 creator A5015163896 @default.
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- W4387566782 creator A5080098914 @default.
- W4387566782 creator A5084429905 @default.
- W4387566782 date "2023-10-01" @default.
- W4387566782 modified "2023-10-15" @default.
- W4387566782 title "Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes" @default.
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