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• W4387567569 abstract "ABSTRACT Animals face unpredictable challenges that require rapid, facultative physiological reactions to support survival but may compromise reproduction. Bats have a long-standing reputation for being highly sensitive to stressors, with sensitivity and resilience varying both within and among species, yet little is known about how stress affects the signaling that regulates reproductive physiology. Here, we provide the first description of the molecular response of the hypothalamic–pituitary–gonadal (HPG) axis of male big brown bats (Eptesicus fuscus) in response to short-term stress using a standardized restraint manipulation. This acute stressor was sufficient to upregulate plasma corticosterone and resulted in a rapid decrease in circulating testosterone. While we did not find differences in the mRNA expression of key steroidogenic enzymes (StAR, aromatase, 5-alpha reductase), seminiferous tubule diameter was reduced in stressed bats coupled with a 5-fold increase in glucocorticoid receptor (GR) mRNA expression in the testes. These changes, in part, may be mediated by RFamide-related peptide (RFRP) because fewer immunoreactive cell bodies were detected in the brains of stressed bats compared with controls – suggesting a possible increase in secretion – and increased RFRP expression locally in the gonads. The rapid sensitivity of the bat testes to stress may be connected to deleterious impacts on tissue health and function as supported by significant transcriptional upregulation of key pro-apoptotic signaling molecules (Bax, cytochrome c). Experiments like this broadly contribute to our understanding of the stronger ecological predictions regarding physiological responses of bats within the context of stress, which may impact decisions surrounding animal handling and conservation approaches." @default.
• W4387567569 created "2023-10-13" @default.
• W4387567569 creator A5026316457 @default.
• W4387567569 creator A5027113256 @default.
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• W4387567569 creator A5082615777 @default.
• W4387567569 date "2023-10-01" @default.
• W4387567569 modified "2023-10-14" @default.
• W4387567569 title "Acute restraint stress rapidly impacts reproductive neuroendocrinology and downstream gonad function in big brown bats (<i>Eptesicus fuscus</i>)" @default.
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• W4387567569 cites W1545663099 @default.
• W4387567569 cites W1843993160 @default.
• W4387567569 cites W1963479720 @default.
• W4387567569 cites W1965983663 @default.
• W4387567569 cites W1967547663 @default.
• W4387567569 cites W1969254161 @default.
• W4387567569 cites W1970332922 @default.
• W4387567569 cites W1973010872 @default.
• W4387567569 cites W1977153704 @default.
• W4387567569 cites W1987536329 @default.
• W4387567569 cites W1989690453 @default.
• W4387567569 cites W1991680271 @default.
• W4387567569 cites W1992690084 @default.
• W4387567569 cites W1999918497 @default.
• W4387567569 cites W2003130072 @default.
• W4387567569 cites W2008742762 @default.
• W4387567569 cites W2014619876 @default.
• W4387567569 cites W2016616411 @default.
• W4387567569 cites W2020113531 @default.
• W4387567569 cites W2024749335 @default.
• W4387567569 cites W2027032549 @default.
• W4387567569 cites W2028546888 @default.
• W4387567569 cites W2031511472 @default.
• W4387567569 cites W2032704291 @default.
• W4387567569 cites W2035496565 @default.
• W4387567569 cites W2035554417 @default.
• W4387567569 cites W2048297293 @default.
• W4387567569 cites W2055077665 @default.
• W4387567569 cites W2056527210 @default.
• W4387567569 cites W2056804509 @default.
• W4387567569 cites W2058710756 @default.
• W4387567569 cites W2061514092 @default.
• W4387567569 cites W2066166647 @default.
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• W4387567569 cites W2077303695 @default.
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• W4387567569 cites W2083599883 @default.
• W4387567569 cites W2085203328 @default.
• W4387567569 cites W2086639164 @default.
• W4387567569 cites W2086697699 @default.
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• W4387567569 cites W2088831319 @default.
• W4387567569 cites W2095036452 @default.
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• W4387567569 cites W2150734066 @default.
• W4387567569 cites W2150921727 @default.
• W4387567569 cites W2153563222 @default.
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• W4387567569 cites W2154778055 @default.
• W4387567569 cites W2161770242 @default.
• W4387567569 cites W2164404412 @default.
• W4387567569 cites W2166905473 @default.
• W4387567569 cites W2168306407 @default.
• W4387567569 cites W2169601302 @default.
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• W4387567569 doi "https://doi.org/10.1242/jeb.245592" @default.
• W4387567569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37827114" @default.
• W4387567569 hasPublicationYear "2023" @default.
• W4387567569 type Work @default.
• W4387567569 citedByCount "0" @default.

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