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• W4387569475 abstract "Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. hACE2 expression is low in the lungs and is upregulated after SARS-CoV-2 infection. How such a hACE2-limited pulmonary environment supports efficient virus transmission and how dynamic hACE2 expression affects SARS-CoV-2 infection are unclear.We generated stable cell lines with different expression levels of hACE2 to evaluate how the hACE2 expression level can affect SARS-CoV-2 transmission.We demonstrated that the hACE2 expression level controls the mode of SARS-CoV-2 transmission. The hACE2-limited cells have an advantage for SARS-CoV-2 shedding, which leads to cell-free transmission. By contrast, enhanced hACE2 expression facilitates the SARS-CoV-2 cell-to-cell transmission. Furthermore, this cell-to-cell transmission is likely facilitated by hACE2-containing vesicles, which accommodate numerous SARS-CoV-2 virions and transport them to neighboring cells through intercellular extensions.This hACE2-mediated switch between cell-free and cell-to-cell transmission routes provides SARS-CoV-2 with advantages for either viral spread or evasion of humoral immunity, thereby contributing to the COVID-19 pandemic and pathogenesis." @default.
• W4387569475 created "2023-10-13" @default.
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• W4387569475 date "2023-10-12" @default.
• W4387569475 modified "2023-10-15" @default.
• W4387569475 title "Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission" @default.
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• W4387569475 doi "https://doi.org/10.1186/s12929-023-00980-w" @default.
• W4387569475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37828601" @default.
• W4387569475 hasPublicationYear "2023" @default.
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