Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387569596> ?p ?o ?g. }
- W4387569596 abstract "The effectiveness of immune checkpoint inhibitors in treating gallbladder cancer (GBC) remains unsatisfactory. Recently, several new immune checkpoints have been identified. However, investigations exploring these immune checkpoints in GBC are limited. In this study, we aim to investigate the expression patterns and clinical implications of various immune checkpoints, and further characterize the spatial and quantitative heterogeneity of immune components in GBC.We employed single and multiplex immunohistochemistry to evaluate the expression of five immune checkpoint markers and four immune cell markers in the primary tumor core, hepatic invasion margin, and liver metastasis. Subsequently, we analyzed their interrelationships and their prognostic significance.We observed a robust positive correlation between PD1/TIM3 expression in GBC (R = 0.614, P < 0.001). The co-expression of PD1/TIM3 exhibited a synergistic effect in predicting poor prognosis among postoperative GBC patients. Further analysis revealed that the prognostic significance of PD1/TIM3 was prominent in the subgroup with high infiltration of CD8 + T cells (P < 0.001). Multiplex immunohistochemistry reveals that PD1 + TIM3 + FOXP3 + cells constitute a significant proportion of FOXP3 + TILs in GBC tissue. Moreover, the co-high expression of PD1 and TIM3 is positively correlated with the accumulation of CD8 + TILs at the hepatic invasion margin. Lastly, our findings indicated reduced expression levels of immune checkpoints and diminished immune cell infiltration in liver metastases compared to primary tumors.Increased co-expression of PD1/TIM3 is associated with poor prognosis in GBC patients and is related to the heterogeneity of immune microenvironment between GBC primary tumor and its hepatic invasion margin or liver metastases, which may be a potential target for future immunotherapy of GBC." @default.
- W4387569596 created "2023-10-13" @default.
- W4387569596 creator A5008027617 @default.
- W4387569596 creator A5012067060 @default.
- W4387569596 creator A5019550828 @default.
- W4387569596 creator A5039086738 @default.
- W4387569596 creator A5043670604 @default.
- W4387569596 creator A5051815365 @default.
- W4387569596 creator A5075877965 @default.
- W4387569596 creator A5079221585 @default.
- W4387569596 creator A5081726386 @default.
- W4387569596 creator A5082929705 @default.
- W4387569596 creator A5091798976 @default.
- W4387569596 date "2023-10-12" @default.
- W4387569596 modified "2023-10-15" @default.
- W4387569596 title "Increased co-expression of PD1 and TIM3 is associated with poor prognosis and immune microenvironment heterogeneity in gallbladder cancer" @default.
- W4387569596 cites W1493283693 @default.
- W4387569596 cites W1889335134 @default.
- W4387569596 cites W1963758164 @default.
- W4387569596 cites W1976105607 @default.
- W4387569596 cites W1982505108 @default.
- W4387569596 cites W2033278321 @default.
- W4387569596 cites W2106050839 @default.
- W4387569596 cites W2107598346 @default.
- W4387569596 cites W2133650808 @default.
- W4387569596 cites W2149121521 @default.
- W4387569596 cites W2153932922 @default.
- W4387569596 cites W2166752790 @default.
- W4387569596 cites W2262673463 @default.
- W4387569596 cites W2338890931 @default.
- W4387569596 cites W2410864298 @default.
- W4387569596 cites W2515826986 @default.
- W4387569596 cites W2531056238 @default.
- W4387569596 cites W2796248490 @default.
- W4387569596 cites W2799346970 @default.
- W4387569596 cites W2806413170 @default.
- W4387569596 cites W2807404046 @default.
- W4387569596 cites W2808421749 @default.
- W4387569596 cites W2883150683 @default.
- W4387569596 cites W2907564726 @default.
- W4387569596 cites W2913986521 @default.
- W4387569596 cites W2922475342 @default.
- W4387569596 cites W2929109925 @default.
- W4387569596 cites W2952481429 @default.
- W4387569596 cites W2954811145 @default.
- W4387569596 cites W2994223194 @default.
- W4387569596 cites W3000208880 @default.
- W4387569596 cites W3025581676 @default.
- W4387569596 cites W3029799931 @default.
- W4387569596 cites W3042467660 @default.
- W4387569596 cites W3047081808 @default.
- W4387569596 cites W3081104994 @default.
- W4387569596 cites W3124058635 @default.
- W4387569596 cites W3128131226 @default.
- W4387569596 cites W3128803455 @default.
- W4387569596 cites W3203114048 @default.
- W4387569596 cites W3212804507 @default.
- W4387569596 cites W4221030130 @default.
- W4387569596 cites W4226161421 @default.
- W4387569596 cites W4281665196 @default.
- W4387569596 cites W4282935115 @default.
- W4387569596 cites W4286299147 @default.
- W4387569596 cites W4296767444 @default.
- W4387569596 cites W4307359779 @default.
- W4387569596 cites W4318778265 @default.
- W4387569596 cites W4378745093 @default.
- W4387569596 cites W4380883081 @default.
- W4387569596 cites W4381249426 @default.
- W4387569596 cites W4382680794 @default.
- W4387569596 cites W4385955972 @default.
- W4387569596 cites W4385956055 @default.
- W4387569596 cites W4386091349 @default.
- W4387569596 doi "https://doi.org/10.1186/s12967-023-04589-3" @default.
- W4387569596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37828574" @default.
- W4387569596 hasPublicationYear "2023" @default.
- W4387569596 type Work @default.
- W4387569596 citedByCount "0" @default.
- W4387569596 crossrefType "journal-article" @default.
- W4387569596 hasAuthorship W4387569596A5008027617 @default.
- W4387569596 hasAuthorship W4387569596A5012067060 @default.
- W4387569596 hasAuthorship W4387569596A5019550828 @default.
- W4387569596 hasAuthorship W4387569596A5039086738 @default.
- W4387569596 hasAuthorship W4387569596A5043670604 @default.
- W4387569596 hasAuthorship W4387569596A5051815365 @default.
- W4387569596 hasAuthorship W4387569596A5075877965 @default.
- W4387569596 hasAuthorship W4387569596A5079221585 @default.
- W4387569596 hasAuthorship W4387569596A5081726386 @default.
- W4387569596 hasAuthorship W4387569596A5082929705 @default.
- W4387569596 hasAuthorship W4387569596A5091798976 @default.
- W4387569596 hasBestOaLocation W43875695961 @default.
- W4387569596 hasConcept C126322002 @default.
- W4387569596 hasConcept C143998085 @default.
- W4387569596 hasConcept C167672396 @default.
- W4387569596 hasConcept C203014093 @default.
- W4387569596 hasConcept C204232928 @default.
- W4387569596 hasConcept C2776107976 @default.
- W4387569596 hasConcept C2776534502 @default.
- W4387569596 hasConcept C2777148285 @default.
- W4387569596 hasConcept C2777701055 @default.
- W4387569596 hasConcept C2779727006 @default.