Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387569659> ?p ?o ?g. }
- W4387569659 abstract "Transcriptional repressor, hypermethylated in cancer 1 (HIC1) participates in a range of important biological processes, such as tumor repression, immune suppression, embryonic development and epigenetic gene regulation. Further to these, we previously demonstrated that HIC1 provides a significant contribution to the function and development of regulatory T (Treg) cells. However, the mechanism by which it regulates these processes was not apparent. To address this question, we used affinity-purification mass spectrometry to characterize the HIC1 interactome in human Treg cells. Altogether 61 high-confidence interactors were identified, including IKZF3, which is a key transcription factor in the development of Treg cells. The biological processes associated with these interacting proteins include protein transport, mRNA processing, non-coding (ncRNA) transcription and RNA metabolism. The results revealed that HIC1 is part of a FOXP3-RUNX1-CBFB protein complex that regulates Treg signature genes thus improving our understanding of HIC1 function during early Treg cell differentiation." @default.
- W4387569659 created "2023-10-13" @default.
- W4387569659 creator A5003114342 @default.
- W4387569659 creator A5004260968 @default.
- W4387569659 creator A5019388134 @default.
- W4387569659 creator A5019589476 @default.
- W4387569659 creator A5028727607 @default.
- W4387569659 creator A5029683473 @default.
- W4387569659 creator A5070915778 @default.
- W4387569659 creator A5074228028 @default.
- W4387569659 creator A5086757422 @default.
- W4387569659 creator A5087708445 @default.
- W4387569659 creator A5090983940 @default.
- W4387569659 creator A5091956053 @default.
- W4387569659 date "2023-10-01" @default.
- W4387569659 modified "2023-10-13" @default.
- W4387569659 title "HIC1 interacts with FOXP3 multi protein complex: novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function" @default.
- W4387569659 cites W1747519355 @default.
- W4387569659 cites W1925000049 @default.
- W4387569659 cites W1940451643 @default.
- W4387569659 cites W1967351618 @default.
- W4387569659 cites W1973020652 @default.
- W4387569659 cites W1978481960 @default.
- W4387569659 cites W1994160001 @default.
- W4387569659 cites W1996076856 @default.
- W4387569659 cites W2002624689 @default.
- W4387569659 cites W2007631222 @default.
- W4387569659 cites W2007708215 @default.
- W4387569659 cites W2009343059 @default.
- W4387569659 cites W2013146483 @default.
- W4387569659 cites W2015587858 @default.
- W4387569659 cites W2024756742 @default.
- W4387569659 cites W2036321220 @default.
- W4387569659 cites W2076176535 @default.
- W4387569659 cites W2080752012 @default.
- W4387569659 cites W2100142435 @default.
- W4387569659 cites W2100566978 @default.
- W4387569659 cites W2107554012 @default.
- W4387569659 cites W2116015828 @default.
- W4387569659 cites W2117438992 @default.
- W4387569659 cites W2133528590 @default.
- W4387569659 cites W2134591209 @default.
- W4387569659 cites W2140155690 @default.
- W4387569659 cites W2141091417 @default.
- W4387569659 cites W2142263069 @default.
- W4387569659 cites W2143417567 @default.
- W4387569659 cites W2148226248 @default.
- W4387569659 cites W2162408694 @default.
- W4387569659 cites W2167844024 @default.
- W4387569659 cites W2177072498 @default.
- W4387569659 cites W2293559256 @default.
- W4387569659 cites W2463195069 @default.
- W4387569659 cites W2513280041 @default.
- W4387569659 cites W2752933178 @default.
- W4387569659 cites W2754312097 @default.
- W4387569659 cites W2787958089 @default.
- W4387569659 cites W2792662781 @default.
- W4387569659 cites W2818540548 @default.
- W4387569659 cites W2890382682 @default.
- W4387569659 cites W2943604356 @default.
- W4387569659 cites W2944293403 @default.
- W4387569659 cites W2979636089 @default.
- W4387569659 cites W3005531462 @default.
- W4387569659 cites W3025414224 @default.
- W4387569659 cites W3135394036 @default.
- W4387569659 cites W3177839058 @default.
- W4387569659 cites W3208691473 @default.
- W4387569659 cites W4210457135 @default.
- W4387569659 cites W4285741876 @default.
- W4387569659 cites W4289688738 @default.
- W4387569659 cites W4308529582 @default.
- W4387569659 doi "https://doi.org/10.1016/j.imlet.2023.09.001" @default.
- W4387569659 hasPublicationYear "2023" @default.
- W4387569659 type Work @default.
- W4387569659 citedByCount "0" @default.
- W4387569659 crossrefType "journal-article" @default.
- W4387569659 hasAuthorship W4387569659A5003114342 @default.
- W4387569659 hasAuthorship W4387569659A5004260968 @default.
- W4387569659 hasAuthorship W4387569659A5019388134 @default.
- W4387569659 hasAuthorship W4387569659A5019589476 @default.
- W4387569659 hasAuthorship W4387569659A5028727607 @default.
- W4387569659 hasAuthorship W4387569659A5029683473 @default.
- W4387569659 hasAuthorship W4387569659A5070915778 @default.
- W4387569659 hasAuthorship W4387569659A5074228028 @default.
- W4387569659 hasAuthorship W4387569659A5086757422 @default.
- W4387569659 hasAuthorship W4387569659A5087708445 @default.
- W4387569659 hasAuthorship W4387569659A5090983940 @default.
- W4387569659 hasAuthorship W4387569659A5091956053 @default.
- W4387569659 hasConcept C104317684 @default.
- W4387569659 hasConcept C145059251 @default.
- W4387569659 hasConcept C148738053 @default.
- W4387569659 hasConcept C158448853 @default.
- W4387569659 hasConcept C165864922 @default.
- W4387569659 hasConcept C2779727006 @default.
- W4387569659 hasConcept C41091548 @default.
- W4387569659 hasConcept C54355233 @default.
- W4387569659 hasConcept C86339819 @default.
- W4387569659 hasConcept C86803240 @default.
- W4387569659 hasConcept C8891405 @default.
- W4387569659 hasConcept C95444343 @default.