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- W4387570151 abstract "Randomized Controlled Trials (RCTs) are considered the gold standard for therapeutic interventions, and it is not uncommon for sweeping changes in medical practice to follow positive results from such trials. However, RCTs are not without their limitations. Physicians frequently view RCTs as infallible, while they tend to dismiss evidence derived from sources other than RCTs as less credible or reliable. In several situations in obstetrics & gynecology, there are no RCTs to help guide the clinician. In these circumstances, it is important to evaluate the entire body of evidence including observational studies, rather than to dismiss interventions altogether simply because no RCTs exist. RCTs and observational studies should be viewed as complementary to each other rather than at odds with each other. Some reversals in widely adopted clinical practice have recently been implemented following subsequent studies that contradicted the outcomes of major RCTs; the most notable of these being the withdrawal from the market of 17-hydroxyprogesterone caproate for preterm birth prevention. Such reversals could potentially have been averted if the inherent limitations of RCTs were carefully considered prior to implementing these universal practice changes. This Clinical Opinion underscores the limitations of an exclusive reliance on RCTs while disregarding other evidence in determining how best to care for patients. Solutions are proposed that advocate that clinicians adopt a more balanced perspective that considers the entirety of the available medical evidence as well as the individual patient characteristics, needs, and wishes." @default.
- W4387570151 created "2023-10-13" @default.
- W4387570151 creator A5008329219 @default.
- W4387570151 date "2023-10-01" @default.
- W4387570151 modified "2023-10-16" @default.
- W4387570151 title "Randomized Controlled Trials: Not Always The “Gold Standard” For Evidence in Obstetrics & Gynecology" @default.
- W4387570151 doi "https://doi.org/10.1016/j.ajog.2023.10.015" @default.
- W4387570151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37838101" @default.
- W4387570151 hasPublicationYear "2023" @default.
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