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- W4387572081 abstract "In ABO-incompatible bone marrow transplantation, an efficient depletion of red blood cells (RBCs) to reduce the volume before transplantation or cryopreservation is mandatory to avoid adverse events in transplanted patients. We evaluated the substitution of the RBC sedimentation using hydroxyethyl starch (HES) with the use of an automated cell separation device using Spectra Optia® (Terumo). Studies have demonstrated efficiency for centrifugation using automated devices with some quantitative variations between methods for volume reduction and RBC depletion and hematopoietic progenitor cells recovery. Median RBC depletion in manual method was of 80% while 97% were observed using Spectra Optia® (Terumo). Median residual RBC volume in the final product was 57 mL in our previous method and 9.6 mL in the automated system. CD34+ cell recovery was 75% and 75%, respectively, for both methods. Median platelet depletion was 22%, while volume reduction was 89% (1.465–172 mL) in automated system and 40% (1.615 to 1.010 mL) in manual method. The processing duration was shorter using an automated method (120–180 min) when compared with the manual method (420–480 min). The automated cell separation device can provide several advantages as an alternative, effective volume reduction and RBC depletion in bone marrow, while providing excellent counts of CD34+ in the final product and optimal processing time of recovery, overall procedural times using the automated method requiring an estimated 2–3 h as opposed to the manual time requirement of around 7–8 h. Another point to consider is that HES is not required. The volume of incompatible RBCs after processing was only 172 mL, and we did not have any adverse reaction at the time of infusion. Regardless of the methods, our patients had satisfactory engraftment of neutrophils and platelets in less than 30 days post-infusion." @default.
- W4387572081 created "2023-10-13" @default.
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- W4387572081 date "2023-10-01" @default.
- W4387572081 modified "2023-10-13" @default.
- W4387572081 title "P‐BT‐19 | Red Cell Reduction of ABO Incompatible Bone Marrow Transplant Cells with Automated Separation Device" @default.
- W4387572081 doi "https://doi.org/10.1111/trf.95_17554" @default.
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