FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387572170> ?p ?o ?g. }

• W4387572170 abstract "Repeat blood donation can cause iron deficiency. Blood collectors use a fingerstick hemoglobin (Hb) test to qualify donors because no point-of-care test is available for ferritin or other measures of iron stores. In some countries, ferritin is measured post-donation to monitor iron stores. In the Netherlands, donors with ferritin level below 30 ng/mL are deferred for their next donation. Although there is a clear physiological association between ferritin and changes in Hb, no quantitative estimate for this association for blood donors has been published. We analyzed data on 29,469 male and 35,292 female repeat blood donors (with 50,390 and 49,862 donations, respectively) with at least two donations between January 2012 and September 2022 for whom Hb level at first donation (baseline) was available and both ferritin and Hb were measured at subsequent donations. We analyzed the association between the log ferritin (lFer) level and the fingerstick Hb change-from-baseline (dHb). As there is a clear changepoint in the association between the dHb and log ferritin levels, we determined the changepoint by maximum likelihood estimation of a two-segmented line, where the right-hand segment has a constant value. We generated confidence intervals calculating various statistics on 1000 bootstrap samples for both the male and female data subsets. To provide an intuitive confirmation of the association, we plotted a rolling mean with a window of n = 1000 observations. On average, male donors contributed 1.7 donations and females 1.4 donations to the data subsets. Of all male and female donations, 37% and 52%, respectively, had ferritin levels below 30 ng/mL. We found a linear association between dHb and lFer for ferritin levels below 30 ng/mL (1.08 mmol/mg [95% confidence interval (CI) 1.02–1.15] for males, 0.59 mmol/mg [95% CI 0.56–0.63] for females). For ferritin levels above 30 ng/mL, we found no change in Hb as a function of lFer. The changepoint for is 30.2 for males (95% CI 28.7–31.8 ng/mL) and 31.4 for females (95% CI 28.5–33.0 ng/mL). The higher changepoint in female donors could be due to selection bias (females with a lower Hb values may be more likely to drop out as a blood donor). Scatterplot of ferritin (plotted on log scale) versus hemoglobin change from baseline." @default.
• W4387572170 created "2023-10-13" @default.
• W4387572170 creator A5002269676 @default.
• W4387572170 creator A5010217596 @default.
• W4387572170 creator A5029746197 @default.
• W4387572170 creator A5036297981 @default.
• W4387572170 creator A5067825589 @default.
• W4387572170 creator A5089817164 @default.
• W4387572170 date "2023-10-01" @default.
• W4387572170 modified "2023-10-13" @default.
• W4387572170 title "OA2‐AM23‐MN‐06 | Change in Hemoglobin as an Indicator of Iron Deficiency in Repeat Blood Donors" @default.
• W4387572170 doi "https://doi.org/10.1111/trf.18_17554" @default.
• W4387572170 hasPublicationYear "2023" @default.
• W4387572170 type Work @default.
• W4387572170 citedByCount "0" @default.
• W4387572170 crossrefType "journal-article" @default.
• W4387572170 hasAuthorship W4387572170A5002269676 @default.
• W4387572170 hasAuthorship W4387572170A5010217596 @default.
• W4387572170 hasAuthorship W4387572170A5029746197 @default.
• W4387572170 hasAuthorship W4387572170A5036297981 @default.
• W4387572170 hasAuthorship W4387572170A5067825589 @default.
• W4387572170 hasAuthorship W4387572170A5089817164 @default.
• W4387572170 hasConcept C126322002 @default.
• W4387572170 hasConcept C134018914 @default.
• W4387572170 hasConcept C1621761 @default.
• W4387572170 hasConcept C162324750 @default.
• W4387572170 hasConcept C203014093 @default.
• W4387572170 hasConcept C2775933685 @default.
• W4387572170 hasConcept C2777417653 @default.
• W4387572170 hasConcept C2777580121 @default.
• W4387572170 hasConcept C2778248108 @default.
• W4387572170 hasConcept C2778319317 @default.
• W4387572170 hasConcept C2778917026 @default.
• W4387572170 hasConcept C2908668021 @default.
• W4387572170 hasConcept C2993617979 @default.
• W4387572170 hasConcept C42407357 @default.
• W4387572170 hasConcept C44249647 @default.
• W4387572170 hasConcept C50522688 @default.
• W4387572170 hasConcept C555293320 @default.
• W4387572170 hasConcept C71924100 @default.
• W4387572170 hasConceptScore W4387572170C126322002 @default.
• W4387572170 hasConceptScore W4387572170C134018914 @default.
• W4387572170 hasConceptScore W4387572170C1621761 @default.
• W4387572170 hasConceptScore W4387572170C162324750 @default.
• W4387572170 hasConceptScore W4387572170C203014093 @default.
• W4387572170 hasConceptScore W4387572170C2775933685 @default.
• W4387572170 hasConceptScore W4387572170C2777417653 @default.
• W4387572170 hasConceptScore W4387572170C2777580121 @default.
• W4387572170 hasConceptScore W4387572170C2778248108 @default.
• W4387572170 hasConceptScore W4387572170C2778319317 @default.
• W4387572170 hasConceptScore W4387572170C2778917026 @default.
• W4387572170 hasConceptScore W4387572170C2908668021 @default.
• W4387572170 hasConceptScore W4387572170C2993617979 @default.
• W4387572170 hasConceptScore W4387572170C42407357 @default.
• W4387572170 hasConceptScore W4387572170C44249647 @default.
• W4387572170 hasConceptScore W4387572170C50522688 @default.
• W4387572170 hasConceptScore W4387572170C555293320 @default.
• W4387572170 hasConceptScore W4387572170C71924100 @default.
• W4387572170 hasIssue "S5" @default.
• W4387572170 hasLocation W43875721701 @default.
• W4387572170 hasOpenAccess W4387572170 @default.
• W4387572170 hasPrimaryLocation W43875721701 @default.
• W4387572170 hasRelatedWork W2028715281 @default.
• W4387572170 hasRelatedWork W2171459390 @default.
• W4387572170 hasRelatedWork W2277050531 @default.
• W4387572170 hasRelatedWork W2318641853 @default.
• W4387572170 hasRelatedWork W2992502660 @default.
• W4387572170 hasRelatedWork W4220674467 @default.
• W4387572170 hasRelatedWork W4220802077 @default.
• W4387572170 hasRelatedWork W56196618 @default.
• W4387572170 hasRelatedWork W2181884599 @default.
• W4387572170 hasRelatedWork W2345436404 @default.
• W4387572170 hasVolume "63" @default.
• W4387572170 isParatext "false" @default.
• W4387572170 isRetracted "false" @default.
• W4387572170 workType "article" @default.