FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387573997> ?p ?o ?g. }

• W4387573997 endingPage "176113" @default.
• W4387573997 startingPage "176113" @default.
• W4387573997 abstract "Peroxisome proliferator-activated receptors (PPARs) are currently among the most focused-on therapeutic targets for non-alcoholic steatohepatitis (NASH), although no clinical transformation has been achieved to date. In this study, we aimed to evaluate the effects of GW9662 on choline-deficient, L-amino acid-defined high-fat diet (CDAA-HFD)-induced NASH mice and reveal the mechanism underlying this effect.GW9662 (1 mg/kg) was administered in CDAA-HFD mouse model of NASH. The effect of GW9662 on hepatic lipid metabolism was investigated using liver RNA-seq and HepG2 cells induced by oleic acid and palmitic acid. In addition, 16S rRNA gene sequencing was performed to analyze the effects of GW9662 on the composition and function of the fecal microbiota.GW9662 improved the CDAA-HFD caused elevation in the levels of ALT, AST, hepatic free fatty acids and triglycerides. The liver pathological analysis indicated that GW9662 alleviated the hepatic steatosis and fibrosis. The NAFLD activity score and RNA-Seq revealed that GW9662 mainly regulated the fatty acids transport and lipid synthesis by inhibiting PPARγ, CD36, FABP1, FASN, and SCD1, and through the up-regulation of PPARα. Moreover, GW9662 reduced the epididymal fat weight. GW9662 reversed the gut microbiota disorder by increasing the abundance of the beneficial bacteria Dubosiella and Lactobacillus and decreasing the abundance of harmful bacteria Lachnospiraceae_NK4A136_group, Helicobacteraceae, Desulfovibriaceae, and Rickenaceae.GW9662 ameliorated lipid metabolism by inhibiting the PPARγ/CD36 pathway and altering the composition of the gut microbiota in NASH mice. Therefore, the PPARγ antagonist GW9662 deserves more attention as a potential therapeutic agent for NASH." @default.
• W4387573997 created "2023-10-13" @default.
• W4387573997 creator A5003654883 @default.
• W4387573997 creator A5008070695 @default.
• W4387573997 creator A5016396916 @default.
• W4387573997 creator A5024010575 @default.
• W4387573997 creator A5027128133 @default.
• W4387573997 creator A5045791329 @default.
• W4387573997 creator A5045999155 @default.
• W4387573997 creator A5078103268 @default.
• W4387573997 date "2023-10-01" @default.
• W4387573997 modified "2023-10-16" @default.
• W4387573997 title "GW9662 ameliorates nonalcoholic steatohepatitis by inhibiting the PPARγ/CD36 pathway and altering the gut microbiota" @default.
• W4387573997 cites W1639924204 @default.
• W4387573997 cites W1964189360 @default.
• W4387573997 cites W1975278319 @default.
• W4387573997 cites W1976621212 @default.
• W4387573997 cites W1978677356 @default.
• W4387573997 cites W1997901667 @default.
• W4387573997 cites W2007887164 @default.
• W4387573997 cites W2013178634 @default.
• W4387573997 cites W2018857061 @default.
• W4387573997 cites W2021758696 @default.
• W4387573997 cites W2035458523 @default.
• W4387573997 cites W2042694297 @default.
• W4387573997 cites W2067740038 @default.
• W4387573997 cites W2071841602 @default.
• W4387573997 cites W2077072558 @default.
• W4387573997 cites W2078176020 @default.
• W4387573997 cites W2088366586 @default.
• W4387573997 cites W2107887255 @default.
• W4387573997 cites W2128211963 @default.
• W4387573997 cites W2129722153 @default.
• W4387573997 cites W2130618859 @default.
• W4387573997 cites W2131254788 @default.
• W4387573997 cites W2136380843 @default.
• W4387573997 cites W2140849098 @default.
• W4387573997 cites W2343723857 @default.
• W4387573997 cites W2401404581 @default.
• W4387573997 cites W2409711614 @default.
• W4387573997 cites W2470709274 @default.
• W4387573997 cites W2558996269 @default.
• W4387573997 cites W2752428556 @default.
• W4387573997 cites W2775026689 @default.
• W4387573997 cites W2902086897 @default.
• W4387573997 cites W2905282109 @default.
• W4387573997 cites W2907015608 @default.
• W4387573997 cites W2921493930 @default.
• W4387573997 cites W2957346331 @default.
• W4387573997 cites W3004885401 @default.
• W4387573997 cites W3015861324 @default.
• W4387573997 cites W3034831360 @default.
• W4387573997 cites W3046258938 @default.
• W4387573997 cites W3094033262 @default.
• W4387573997 cites W3120402636 @default.
• W4387573997 cites W3127506782 @default.
• W4387573997 cites W4214523533 @default.
• W4387573997 cites W4226115421 @default.
• W4387573997 cites W4281648722 @default.
• W4387573997 cites W4291168597 @default.
• W4387573997 cites W4315619045 @default.
• W4387573997 cites W4382361583 @default.
• W4387573997 doi "https://doi.org/10.1016/j.ejphar.2023.176113" @default.
• W4387573997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37838102" @default.
• W4387573997 hasPublicationYear "2023" @default.
• W4387573997 type Work @default.
• W4387573997 citedByCount "0" @default.
• W4387573997 crossrefType "journal-article" @default.
• W4387573997 hasAuthorship W4387573997A5003654883 @default.
• W4387573997 hasAuthorship W4387573997A5008070695 @default.
• W4387573997 hasAuthorship W4387573997A5016396916 @default.
• W4387573997 hasAuthorship W4387573997A5024010575 @default.
• W4387573997 hasAuthorship W4387573997A5027128133 @default.
• W4387573997 hasAuthorship W4387573997A5045791329 @default.
• W4387573997 hasAuthorship W4387573997A5045999155 @default.
• W4387573997 hasAuthorship W4387573997A5078103268 @default.
• W4387573997 hasBestOaLocation W43875739971 @default.
• W4387573997 hasConcept C126322002 @default.
• W4387573997 hasConcept C134018914 @default.
• W4387573997 hasConcept C170493617 @default.
• W4387573997 hasConcept C185592680 @default.
• W4387573997 hasConcept C187345961 @default.
• W4387573997 hasConcept C2776175330 @default.
• W4387573997 hasConcept C2776885963 @default.
• W4387573997 hasConcept C2776954865 @default.
• W4387573997 hasConcept C2778772119 @default.
• W4387573997 hasConcept C2779134260 @default.
• W4387573997 hasConcept C2779478299 @default.
• W4387573997 hasConcept C2779828298 @default.
• W4387573997 hasConcept C3018708256 @default.
• W4387573997 hasConcept C4733338 @default.
• W4387573997 hasConcept C55493867 @default.
• W4387573997 hasConcept C71924100 @default.
• W4387573997 hasConcept C86803240 @default.
• W4387573997 hasConceptScore W4387573997C126322002 @default.
• W4387573997 hasConceptScore W4387573997C134018914 @default.
• W4387573997 hasConceptScore W4387573997C170493617 @default.
• W4387573997 hasConceptScore W4387573997C185592680 @default.

• next