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- W4387574037 abstract "Simultaneous initiation of quadruple therapy with angiotensin receptor-neprilysin inhibitor, beta-adrenergic receptor blocker, mineralocorticoid receptor antagonist, and sodium glucose cotransporter 2 inhibitor aim at prompt improvement and prevention of readmission in hospitalized patients for heart failure with reduced ejection fraction. However, titration of quadruple therapy is time consuming. Lengthy uptitration of quadruple therapy may negate the benefit of early initiation. Quadruple therapy should start with a sodium glucose cotransporter 2 inhibition and a mineralocorticoid antagonist, as both enable safe decongestion and require minimal or no titration. Depending on the level of decongestion and clinical characteristics, patients receive an angiotensin receptor-neprilysin inhibitor or a beta-adrenergic receptor blocker to be titrated after hospital discharge. Outpatient addition of an angiotensin receptor-neprilysin inhibitor to a beta-adrenergic receptor blocker or vice versa completes the quadruple therapy scheme. By focusing on decongestion and matching intervention to patients' profile, the present therapeutic sequence allows rapid implementation of quadruple therapy at fully recommended doses." @default.
- W4387574037 created "2023-10-13" @default.
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- W4387574037 date "2023-10-01" @default.
- W4387574037 modified "2023-10-16" @default.
- W4387574037 title "Patient Centered Heart Failure Therapy" @default.
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- W4387574037 doi "https://doi.org/10.1016/j.amjmed.2023.09.018" @default.
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