Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387575268> ?p ?o ?g. }
- W4387575268 abstract "Abstract Immunotherapies are mainly aimed to promote a CD8 + T cell response rather than a CD4 + T cell response as cytotoxic T lymphocytes (CTLs) can directly kill target cells. Recently, CD4 + T cells have received more attention due to their diverse roles in tumors and chronic viral infections. In antitumor and antichronic viral responses, CD4 + T cells relay help signals through dendritic cells to indirectly regulate CD8 + T cell response, interact with B cells or macrophages to indirectly modulate humoral immunity or macrophage polarization, and inhibit tumor blood vessel formation. Additionally, CD4 + T cells can also exhibit direct cytotoxicity toward target cells. However, regulatory T cells exhibit immunosuppression and CD4 + T cells become exhausted, which promote tumor progression and chronic viral persistence. Finally, we also outline immunotherapies based on CD4 + T cells, including adoptive cell transfer, vaccines, and immune checkpoint blockade. Overall, this review summarizes diverse roles of CD4 + T cells in the antitumor or protumor and chronic viral responses, and also highlights the immunotherapies based on CD4 + T cells, giving a better understanding of their roles in tumors and chronic viral infections." @default.
- W4387575268 created "2023-10-13" @default.
- W4387575268 creator A5027900862 @default.
- W4387575268 creator A5040500880 @default.
- W4387575268 creator A5059124619 @default.
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- W4387575268 creator A5076103004 @default.
- W4387575268 creator A5083659861 @default.
- W4387575268 creator A5089963175 @default.
- W4387575268 date "2023-10-01" @default.
- W4387575268 modified "2023-10-18" @default.
- W4387575268 title "The role of CD4<sup>+</sup> T cells in tumor and chronic viral immune responses" @default.
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